OHSU

Labs

The Department of Biomedical Engineering includes a diverse body of research groups, led by various faculty members. Learn more about some of these researchers' laboratories below.

Sandra Rugonyi Laboratory

Cardiac dynamics image

Sandra Rugonyi researches novel ways to visualize and calculate how biological systems respond to varying conditions, using mathematical and computational models. Dr. Rugonyi's group currently is focused mainly on the study of cardiovascular systems, which includes the analysis of blood flow through vessels and the heart, as well as the interaction of flow with tissue.

Learn more about Sandra Rugonyi

Visit the Sandra Rugonyi Lab website


Vu Nanobiotechnology and Cell Imaging Research Group

vu_image

Tania Vu's group researches imaging nanotechnologies in order to study and diagnose aberrant cellular signaling in disease at the level of single molecules in single cells. These new technologies allow us to detect the amount and sub-cellular location of key cellular signaling proteins with cutting-edge of sensitivity and spatial resolution. Using such new technological capabilities, we seek to understand how cell function emerges from the spatiotemporal interactions of a groups of single proteins. A primary effort is to work with clinicians and industrial partners to translate our technologies into concrete molecular-based personalized diagnostics in the area of cancer and neurological disorders.

Learn More about Tania Vu

Read more about the Vu Nanobiotechnology and Cell Imaging Research Group


Yantasee Laboratory (functionalized nanomaterials in medicine and medical devices)

Wassana Yantasee Lab Members 2013

Wassana Yantasee's Lab researches functionalized nanomaterials in medicine, development of animal models of cancer, kidney disease, and metals-related diseases, and development of engineered nanomaterials to diagnose, prevent, and treat disease.

Learn More about Wassana Yantasee

Visit the Yantasee Lab website


ORCATECH

Elderly patient using computer tablet device

BME Faculty Pete Jacobs, along with BME collaborator Jeff Kaye, are part of ORCATECH, a multi-disciplinary organization that is transforming clinical research by developing and implementing leading-edge technologies that harvest data in real time from people in their natural living situations. The data we gather, and what we learn and study can be applied to helping elders (and others) live longer, healthier lives at home; developing new medical technology and products; and creating better medical research studies. Our unique expertise provides the opportunity to collaborate with other academic and industry partners in areas ranging from focus groups to field-testing and high-resolution data handling and analysis.

Visit the ORCATECH website


Biomedical Optics (Jacques Lab)

Light penetration into human brain is modeled by 3D Monte Carlo simulations

Steven Jacques and his lab develop novel applications of light in medicine and biology. Light can be diagnostic or therapeutic/surgical:
· Where tissue affects photons, light is used for diagnostic imaging, spectroscopy and sensing,
· Where photons affect tissue, lasers are used for therapeutic and surgical cutting, dissecting, machining, processing, coagulating, welding, and oxidizing tissues and biomaterials.

The Jacques Lab develops novel microscopes, cameras and optical fiber probes for use in medical research and clinical care.

FIGURE: Light penetration into human brain is modeled by 3D Monte Carlo simulations.

Learn More about Steven Jacques

Visit the Biomedical Optics website


Xiaolin Nan Laboratory

TIRF (total internal reflection fluorescence) microscopy image

Xiaolin Nan studies single molecule spatial systems biology, with a particular interest in understanding how oncogenic signaling modules are assembled and operate in their cellular context and seeking their practical use in designing novel cancer therapeutics. His research group takes a multidisciplinary approach that combines biological nanoscopy, biochemistry and bioengineering, and computation to address these challenges.

Learn more about Xiaolin Nan

Visit the Xiaolin Nan Lab website


Summer Gibbs Laboratory

Researcher with Experimental Fluorophores in Test Tubes

Summer Gibbs' Lab is focused on the development of optimized imaging reagents to expand the capabilities of macroscopic and microscopic cancer imaging. This includes fluorophore development for image-guided surgery, superresolution microscopy, and correlative light and electron microscopy to visualize and characterize cancer from the operating room to the single cell level.

Learn more about Summer Gibbs

Visit the Gibbs Lab Website


Kimberly Beatty Laboratory

Beatty-Sulfatase Probes overview

Dr. Beatty's research group is working at the interface of chemistry and infectious disease to understand Mycobacterium tuberculosis (M.tb.), the bacterial pathogen that causes tuberculosis (TB). Overall, her group is creating a new chemical tools and molecular imaging approaches to interrogate latent TB infections and the stages of pathogenesis, with the goal of uncovering new diagnostic and therapeutic targets. Her program employs small molecule probes to elucidate the regulation of mycobacterial enzymes in TB infections and to identify enzymes that can be used in diagnostic assays. In order to look at enzyme activity in real time, her group is synthesizing a variety of enzyme substrate mimics that are fluorogenic probes, which undergo a large change in fluorescence emission and quantum yield upon hydrolysis. These probes will be used to image and quantify distinct enzyme activities (e.g., sulfatases and lipases) at different stages of infection.

Learn More about Kimberly Beatty

Peter Jacobs Laboratory

Artificial Pancreas

Peter Jacobs' Laboratory has numerous ongoing projects, all with a focus on researching, designing and translating novel medical devices and systems for use by patients within natural living environments. The projects broadly fit within the following areas:
· Ubiquitous computing for delivering home-based health care solutions
· Hearing science, specifically hearing aid signal processing and use of otoacoustic emissions for hearing diagnostics
· Medical device development primarily in the area of diabetes

Learn more about Peter Jacobs

Visit the Jacobs Lab website