Welcome from the Chair

Susan HayflickBiochemistry underpins many of the basic biomedical sciences, from molecular genetics to immunology and pharmacology.  Biochemists identify the molecular players in cellular function and their mechanisms of action. Students in the Department of Biochemistry and Molecular Biology come to learn, in atomic detail, about the molecular interactions common to basic life processes, and the techniques that illuminate the molecular underpinnings of normal physiology and the diseased state.  Our faculty are experts in the methods of molecular genetics, protein biochemistry, enzymology, x-ray crystallography, mass spectrometry and electron microscopy.  Application areas range widely from the genetic causes of cancer, to protein synthesis and modification, to cell communication, signal transduction and the metabolic pathways of parasites, viral cell entry, and to the fundamentals of bio-molecular structure and dynamics. Learn more

Selected Publications

Babur Ö, Ngo ATP, Rigg RA, Pang J, Rub ZT, Buchanan AE, Mitrugno A, David LL, McCarty OJT, Demir E, Aslan JE. Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis. Am J Physiol Cell Physiol. 2018 May 1;314(5):C603-C615. Epub 2018 Feb 7. PubMed PMID: 29412690.

Hulett TW, Jensen SM, Wilmarth PA, Reddy AP, Ballesteros-Merino C, Afentoulis ME, Dubay C, David LL, Fox BA. Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination. J Immunother Cancer. 2018 Apr 5;6(1):27. PubMed PMID: 29618380.

Hosseini MM, Kurtz SE, Abdelhamed S, Mahmood S, Davare MA, Kaempf A, Elferich L, McDermott JE, Liu T, Payne SH, Shinde U, Rodland KD, Mori M, Druker BJ, Singer JW, Agarwal A. Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes. Leukemia. 2018 Mar 29; PubMed PMID: 29743719.

Smith JR, David LL, Appukuttan B, Wilmarth PA. Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs. Am J Ophthalmol. 2018 Mar 17; PubMed PMID: 29559410.

Platt, E, Smith, L, Thayer, M. L1 retrotransposon antisense RNA within ASAR IncRNAs controls chromosome-wide replication timing. J of Cell Biology. 2017 Dec 29; DOI: 10.1083/jcb.201707082.

Martin GM, Kandasamy B, DiMaio F, Yoshioka C, Shyng S-L. Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM. eLife. 2017 Oct 24; 6:31054.

Boswell BA, Korol A, West-Mays JA, Musil LS. Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract. Mol Biol Cell. 2017 Apr 1;28(7):907-921. PubMed PMID: 28209733.

Martin GM, Yoshioka C, Rex E, Fay J, Xie Q, Whorton MR, Chen JZ, Shyng S-LCryo-EM structure of the ATP-sensitive potassium channel  illuminates mechanisms of assembly and gating. eLife. 2017 Jan 16; 6:e24149.

 

 

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