Marie-Pierre Hasne obtained a Doctor of Pharmacy degree from the Université Claude-Bernard (Lyon, France) in 1998, and a Ph.D. in Biochemical Parasitology from Glasgow University (Scotland, U.K.) in 2001. She conducted her postdoctoral studies at Oregon Health & Science University and became a Research Assistant Professor in the Department of Biochemistry and Molecular Biology in 2010.
Our research explores host-parasite interactions with a particular interest for a group of protozoan parasites—the trypanosomatids—that encompasses important human pathogens: Leishmania, Trypanosoma brucei and Trypanosoma cruzi. We are focusing on two important aspects of parasite biology: nutrient transport and host cell remodeling following parasite infection. Nutrient transport is a vital component for parasite survival as parasitic organisms depend on their host for nutrition. Amino-acids and polyamines are of particular importance for these organisms and we explore the biochemical characteristics, the structural organization, the regulation and cellular location of amino-acid and polyamine transporters. A second aspect of our research looks at the architecture constituting host-parasite interactions. Using the intracellular parasite T. cruzi as a model, and high-resolution electron microscopy as a primary tool, we are investigating the space between host and parasites to identify proteins forming host-parasite interactions; we are also attempting to map the extent of host cell remodeling upon parasite invasion.