OHSU

Research Faculty

Nicola Carter, PhD
Research Assistant Professor, Ullman Lab
 
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Marie Pierre-Hasne, PhD
Research Assistant Professor, Ullman Lab
 
Marie-Pierre Hasne obtained a Doctor of Pharmacy degree from the Université Claude-Bernard (Lyon, France) in 1998, and a Ph.D. in Biochemical Parasitology from Glasgow University (Scotland, U.K.) in 2001. She conducted her postdoctoral studies at Oregon Health & Science University and became a Research Assistant Professor in the Department of Biochemistry and Molecular Biology in 2010.
 
Our research explores host-parasite interactions with a particular interest for a group of protozoan parasites—the trypanosomatids—that encompasses important human pathogens: Leishmania, Trypanosoma brucei and Trypanosoma cruzi. We are focusing on two important aspects of parasite biology: nutrient transport and host cell remodeling following parasite infection. Nutrient transport is a vital component for parasite survival as parasitic organisms depend on their host for nutrition. Amino-acids and polyamines are of particular importance for these organisms and we explore the biochemical characteristics, the structural organization, the regulation and cellular location of amino-acid and polyamine transporters. A second aspect of our research looks at the architecture constituting host-parasite interactions. Using the intracellular parasite T. cruzi as a model, and high-resolution electron microscopy as a primary tool, we are investigating the space between host and parasites to identify proteins forming host-parasite interactions; we are also attempting to map the extent of host cell remodeling upon parasite invasion.
 
Aditi Mukherjee, PhD
Research Assistant Professor, Rotwein Lab
 
Phillip Wilmarth, PhD
Research Assistant Professor, David Lab
 
Phil Yates, PhD
Research Assistant Professor, Ullman Lab