Welcome from the Chair

Dr. ChapmanBiochemistry underpins many of the basic biomedical sciences, from molecular genetics to immunology and pharmacology.  Biochemists identify the molecular players in cellular function and their mechanisms of action. Students in the Department of Biochemistry and Molecular Biology come to learn, in atomic detail, about the molecular interactions common to basic life processes, and the techniques that illuminate the molecular underpinnings of normal physiology and the diseased state.  Our faculty are experts in the methods of molecular genetics, protein biochemistry, enzymology, x-ray crystallography, mass spectrometry and electron microscopy.  Application areas range widely from the genetic causes of cancer, to protein synthesis and modification, to cell communication, signal transduction and the metabolic pathways of parasites, viral cell entry, and to the fundamentals of bio-molecular structure and dynamics. Learn more

Selected Publications

Cambronne XA, Stewart ML, Kim D, Jones-Brunette AM, Morgan RK, Farrens DL, Cohen MS, Goodman RH. Biosensor reveals multiple sources for mitochondrial NAD. Science. 2016 Jun 17;352 (6292):1474-7. PMID: 27313049

Pillay S, Meyer NL, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, Carette JE.  An essential receptor for adeno-associated virus infection.  Nature. 2016 Feb 4;530 (7588): 108-12. PMID: 26814968

Wu Y, Shyng SL, Chen PC. Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.  J Biol Chem. 2015 Dec 11;290 (50):29676-90.PMID: 26453299.

Donley N, Smith L, Thayer MJ. ASAR15, A cis-acting locus that controls chromosome-wide replication timing and stability of human chromosome 15. PLoS Genet 2015;11(1):e1004923. PMID: 25569254

Hasne MP, Soysa R, Ullman B. The Trypanosoma cruzi Diamine Transporter Is Essential for Robust Infection of Mammalian Cells. PLoS One.  2016 Apr6;11(4):e0152715. doi: 10.1371/journal.pone.0152715. eCollection 2016. PMID:27050410.

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