Jacob Raber, Ph.D.
Positions
Professor, Behavioral Neuroscience
Professor, Department of Neurology
Affiliate Scientist, Division of Neuroscience, ONPRC
Contact
raberj@ohsu.edu; Phone: 503 494-1524; Lab Phone: 503 494-1431; Fax: 503 494-6877; Office: MRB708; Mail Code: L470
Research Interests
aging, alzheimer's disease, androgen receptor, sex differences, histamine, apoE, methamphetamine, irradiation, neurogenesis, cognitive function, behavioral
Preceptor Rotation Availability
Dr. Raber is available for preceptor rotations for all upcoming academic terms
Mentorship Availability
Dr. Raber is available for mentorship for the 2011/12 and 2012/13 academic years
Summary of Current Research
Our research focuses on effects of genetic factors, such as apoE, and environmental factors on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these diseases. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.
We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.
Recent Publications
Acevedo, S.F., de Esch, I.J.P., Raber, J. (2007) Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure. Neuropsychopharamcology. 32, 665-672.
Villasana, L., Rosenberg, J., Raber, J. (2010) Sex-dependent effects of 56Fe irradiation on contextual fear conditioning. Hippocampus, 20, 19-23.
Benice, T.S., Raber, J. (2009) Testosterone and dihydrotestosterone differentially improve cognition in aged female mice. Learning and Memory, 16, 479-485.
Acevedo, S.F., Piper, B., Raber, J. (2010) Apolipoprotein E4 and sex affect neurobehavioral performance in primary school children. Pediatric Research, 67, 293-299.
Raber, J., Villasana, L., Rosenberg, J., Zou, Y., Huang, T.T., Fike, J.R. (2011) Irradiation enhances hippocampus-dependent cognition in extracellular superoxide dismutase deficient mice. Hippocampus, 21, 72-80.
Siegel, J.S., Park, B., Raber, J. (2011) Methamphetamine exposure during brain development alters the brain acetylcholine system in adolescent mice. Journal of Neurochemistry, 119, 89-99.
Haley, G.E., Berteau-Pavy, F., Berteau-Pavy, D., Raber, J. (2012) Novel image location object recognition task sensitive to detect age-related cognitive decline in non-demented elderly. AGE, 34, 1-10.
Siegel, J.S., Haley, G.E., Raber, J. (2012) Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice. Neurobiol Aging, 33, 345-358.
Haley, G.E., McGuire, A., Berteau-Pavy, D., Weiss, A., Patel, R., Messaoudi, I., Urbanski, H.F., Raber, J. (2011) Measures of anxiety, amygdala volumes, and hippocampal scopolamine phMRI response in elderly female rhesus macaques. Neuropharmacology, epub ahead of print, in press.
Haley, G.E.*, Villasana, L.*, Dayger, C., Davis, M.J., Raber, J. (2012) ApoE genotype-dependent paradoxical short-term effects of 56Fe irradiation on the brain. International Journal of Radiation Oncology Biology Physics, in press.
Also see Dr. Raber's PubMed Listing
Education
Ph.D., 1991, The Weizmann Institute of Science, Rehovot, Israel
M.Sc., 1986, Free University, Amsterdam, The Netherlands
B.Sc., 1983, Free University, Amsterdam, The Netherlands
Previous Positions
1991-1995 Postdoctoral Researcher, The Scripps Research Institute, La Jolla, CA.
1996-1998 Staff Research Investigator, Gladstone Molecular Neurobiology Program, San Francisco, CA; Adjunct Instructor of Neurology, University of California, San Francisco, California.
1998-2000 Staff Research Scientist I, Gladstone Institute of Neurological Disease, San Francisco, CA.
2000-2001 Staff Research Scientist II, Gladstone Institute of Neurological Disease, San Francisco, CA.
1998-2001 Assistant Adjunct Professor of Neurology, University of California, San Francisco, CA.
Non-Academic Interest
Photography
