Christa Helms
Ph.D. Graduate (2006)
Undergraduate Education
(2001) B.A. Psychology, Reed College
Training at OHSU
2001 - 2006
Second Year Project
(2003) Delay-concurrent stimulus effects in the adjusting amount procedure. (Mentor: Suzanne Mitchell)
Dissertation
(2006) Adaptation of choice behavior in concurrent chains schedules and the role of the basolateral amygdala. (Mentor: Suzanne Mitchell, Ph.D.)
Current Positions
Staff Scientist, Oregon National Primate Research Center, Beaverton OR
Publications
Helms, C.M., Reeves, J.M. & Mitchell, S.H. (2006). Impact of strain and D-amphetamine on impulsivity (delay discounting) in inbred mice. Psychopharmacology , 188, 144-151.
Helms CM, Gubner NR, Wilhelm CJ, Mitchell SH, Grandy DKG. (2008) D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking. Pharmacology, Biochemistry, and Behavior, 90:387-393. PMID: 18456309; PMC2603181
Helms CM, Mitchell SH (2008) Basolateral amygdala lesions disrupt within session changes in preference after reinforcer magnitude reversal. Behavioural Brain Research, 191:210-218. PMID: 18455812; PMC2475334
Helms CM, Rogers LSM, Grant KA (2008) Zolpidem generalization and antagonism in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol. Alcoholism: Clinical and Experimental Research, 32:1197-1206. PMID: 18482161; PMC2517055
Grant KA, Helms CM, Rogers LSM, Purdy RH (2008) Neuroactive steroid stereospecificity of ethanol-like discriminative stimulus effects in monkeys. Journal of Pharmacology and Experimental Therapeutics, 326:354-361. PMID: 18436788; PMC2562878
Helms CM, Rogers LSM, Grant KA (2008) Gamma-hydroxybutyrate does not substitute for the discriminative stimulus effects of ethanol in cynomolgus monkeys. Behavioural Pharmacology, 19:317-324. PMID: 18622179; PMC2704122
Helms CM, Rogers LSM, Grant KA (2009) Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital and midazolam in cynomolgus monkeys: comparison of Ro15-4513 and Ro15-1788. Journal of Pharmacology and Experimental Therapeutics, 331:142-152. PMID: 19641166; PMC2766226
Helms CM, Grant KA (2011) The effect of age on the discriminative stimulus effects of ethanol and its GABAA receptor mediation. Psychopharmacology 216: 333-343. PMID: 21340471; PMC3134136.
Helms CM, Messaoudi I, Jeng S, Freeman W, Vrana KE, Grant KA. (2011) A longitudinal analysis of circulating stress-related proteins and chronic ethanol self-administration in cynomolgus macaques. Alcoholism: Clinical and Experimental Research. Dec 5. doi: 10.1111/j.1530-0277.2011.01685.x. [Epub ahead of print] PMID: 22141444 ; PMC3324628.
Cuzon Carlson VC, Seabold GK, Helms CM, Garg N, Odagiri M, Rau AR, Daunais J, Alvarez VA, Lovinger DM, Grant KA (2011) Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates. Neuropsychopharmacology doi:10.1038/npp.2011.140. PMID: 21796110.
Helms CM, Rossi D, Grant KA (2012) Neurosteroid effects on sensitivity to ethanol. Front Endocrinology, doi: 10.3389/fendo.2012.00010.
Helms CM, McClintick M, Grant KA (2012) Social rank, chronic ethanol self-administration and hypothalamic-pituitary-adrenal axis response in monkeys. Psychopharmacology. DOI 10.1007/s00213-012-2707-z.
