Four Postdoctoral Opportunities in Dr. Jeffrey Illif's lab, Department of Anesthesiology and Peri-Operative Medicine, Oregon Heath & Science University
A novel perivascular mechanism of cerebrospinal fluid flow, termed the 'glymphatic' system, has recently been described that supports the clearance of wastes including amyloid beta from the brain during sleep (Iliff et al. Sci Translat Med 2012, Xie et al. Science 2013). This finding was identified as one of Science magazine's 'Top 10 Breakthroughs of 2013'. Dysfunction of this glial-vascular system is a feature of both the aging and post-traumatic young brain, and may be one of the factors that renders the aging brain vulnerable to the development of protein aggregates in neurodegenerative diseases such as Alzheimer's disease.
Work in our group now seeks to define 1) the cellular and molecular mechanisms underlying impairment of glymphatic pathway function in the aging and post-traumatic brain, and 2) whether the glymphatic pathway is active in the human brain and whether its impairment is associated with age-related amyloid plaque deposition.
Postdoc Position –Cellular and molecular mechanisms of post-traumatic impairment of glymphatic function.
This position is funded by a new R01 grant (PI, Jeff Iliff), and will focus on the interactions between aging, traumatic brain injury, and neurodegeneration. The fellow will have the opportunity to participate in in vivo animal studies, including 2-photon imaging, MRI, EEG recording and analysis, AAV-based gene manipulation and intracerebral microdialysis. Applicant should have a PhD in Neuroscience, Biochemistry, Physiology, Cell Biology or related field. Prior experience with in vivo models of TBI or neurodegeneration, EEG, MRI or in vivo imaging are desired but not required.
Postdoc Position –Imaging glymphatic pathway function in the sleeping human brain.
This position is funded by a three year grant from the Paul G. Allen Family Foundation and mentored by project PIs Bill Rooney of the OHSU Advanced Imaging Research Center and Jeff Iliff of the OHSU Department of Anesthesiology and Perioperative Medicine. The research aims to advance high-resolution neuro-MRI in the context of early pathophysiological changes associated with sleep and neurodegenerative disease, with an emphasis on measurement of vascular, metabolic and glymphatic functions. Advanced quantitative MR methods and modeling approaches that include in vivo relaxometry, dynamic contrast-enhanced MRI, metabolic imaging and spectroscopy, and associated techniques will be extended and applied. The successful candidate will work as part of a multi-disciplinary research team and will interact with physicists, chemists, engineers, physiologists, computer scientists, neuropsychologists, radiologists and neurologists. Applicant should have a PhD or equivalent in Chemistry, Biomedical Engineering, Biophysics, Neuroscience, Electrical Engineering, or a related field. The ideal candidate will have substantial research background in MR physics and molecular principles, brain physiology, and computing skills. MR pulse sequence programming skills are desired.
Postdoc Position –Implementation of MR-EEG to evaluate glymphatic function in the human brain.
This position is funded by a three year grant from the Paul G. Allen Family Foundation and is co-mentored by Drs. Miranda Lim of the Portland VA Medical Center, Bill Rooney of the OHSU Advanced Imaging Research Center, and Jeff Iliff from the OHSU Department of Anesthesiology and Perioperative Medicine. The overall goal of this project is to evaluate how changes in sleep, interstitial protein clearance, and chronic neurodegeneration interact in the aged brain. The fellow will focus on the implementation of MRI-compatible EEG and the support of MRI studies in human and animal studies, including screening human subjects for sleep patterns, training them in the MRI simulator, recording/scoring sleep-wake EEG, and EEG signal processing and integration with imaging data. The successful candidate will work as part of a multi-disciplinary research team and will interact with physicists, chemists, engineers, physiologists, computer scientists, neuropsychologists, radiologists and neurologists. Applicant should have a PhD or equivalent in Neuroscience, Biomedical Engineering, Electrical Engineering, Computational Biology, Physics, or a related field. The ideal candidate will have substantial research background in in vivo human neurophysiology and MR imaging, proficiency in sophisticated analysis of electrophysiological signals such as EEG and imaging data, use of MATLAB, R or equivalent.
Research Fellowship –Sleep and neurodegeneration in the post-traumatic brain
A 2-year postdoctoral fellowship position (through the VA Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC) Advanced Research) conducting basic and translational neuroscience is available for MD or MD/PhD trainees that have completed an ACGME-accredited residency. The VA Northwest Network MIRECC's mission addresses military posttraumatic stress disorder and its complex comorbidities, including traumatic brain injury (TBI). The fellowship offered focuses on the interactions between sleep and neurodegeneration in the aging and post-traumatic brain. The fellow will focus on post-traumatic changes in sleep-wake biology, and their effect on the function of the newly-described glymphatic pathway, including studies in animal models of TBI employing 2-photon imaging, MRI, EEG and intracerebral microdialysis. They will also work as part of a multi-disciplinary research team through mentors/collaborators at Oregon Health &Science University (Dr. Jeffrey Iliff), the OHSU Advanced Imaging Research Center (Dr. Bill Rooney), the OHSU Layton Aging and Alzheimer's Disease Center (Drs. Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Randy Woltjer), VA Portland (Dr. Miranda Lim), VA Puget Sound and University of Washington in Seattle (Drs. Elaine Peskind and Murray Raskind) to translate these findings into human subjects, including human histopathological specimens, CSF biomarker analysis, and novel clinical neuroimaging approaches.
Contact: Dr. Jeffrey Iliff, PhD (firstname.lastname@example.org)
University of Pittsburgh
Postdoctoral Fellowship in Cytokine and Regulatory Cell Networks
An opportunity is immediately available in the laboratory of Dr. Hēth R. Turnquist for a motivated individual with a recent PhD and/or MD. This position is part of NIH-funded studies aiming to develop an understanding of the cytokine networks that direct immune responses responsible for both protective and pathological immunity. These findings will be translated into therapies benefiting organ and bone marrow transplant recipients. Click here for more information.
NIH National Heart, Lung and Blood Institute
Postdoctoral Position in Neural Development and Regeneration
A position is available in the lab of Dr. Herbert Geller at NIH to study the role of extracellular matrix proteoglycans in controlling axonal growth during development and after injury to the nervous system. We are especially interested in how proteoglycans signal to neurons, including the structure/function relationship within glycosaminoglycan chains, the identification of neuronal receptors for GAG chains, and the intracellular signal transduction pathways activated by GAG chains. Our lab uses all appropriate techniques including cell culture and animal experiments, with the tools of biochemistry, biophysics, cell biology, and molecular biology, and takes advantage of outstanding NIH core facilities that use confocal and superresolution as well as electron microscopy, mass spectromety, proteomic and transgenic approaches. Experience with cell and molecular techniques and microscopy and an interest in neural development or regeneration are essential. Some projects involve collaboration with biotech partners. Applicants must be recent or soon-to-be Ph.D.s. For more information on the lab, please visit our web site:https://www.nhlbi.nih.gov/research/intramural/researchers/pi/geller-herbert
To apply: Send a cover letter with a statement of research interests and career goals, curriculum vita and names of at least three references in one pdf file. Send to Dr. Herbert Geller, NHLBI, email@example.com.