List of publications

Danielle Williamson 3MT State Competition 2014


MD/PhD students are involved in a wide variety of research projects across the OHSU campuses. Below are selected recent journal articles. Student names are in bold.



Baker-Groberg SM*, Bornstein S*, Zilberman-Rudenko J, Schmidt M, Tormoen GW, Kernan C, Thomas CR Jr, Wong MH, Phillips KG, McCarty OJT. Effect of ionizing radiation on the physical biology of head and neck squamous cell carcinoma cells. Cell Mol Bioeng. 2015 Sep 1;8(3):517-525. Epub 2015 May 7.

Doberne JW, Kakaday R, Redd T, Lattin D, Yackel TR, Eriksson CO, Mohan V, Gold JA, Ash JS, Chiang MF. Barriers to Information Access in Electronic Health Records during Initial Patient Visits: A Qualitative Study. Proceedings of the HFES 2015 International Symposium on Human Factors and Ergonomics in Health Care: Improving the Outcomes. 2015 in Press. [Epub ahead of print]

Feng Z, Puri S, Moudgil T, Wood W, Hoyt CC, Wang C, Urba WJ, Curti BD, Bifulco CB, Fox BA. Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma.J Immunother Cancer. 2015 Oct 20;3:47. doi: 10.1186/s40425-015-0091-z. eCollection 2015.

Hornick N, Huan J, Doron B, Goloviznina N, Lapidus J, Chang B, Kurre P. Serum Exosome MicroRNA as a Minimally-Invasive Early Biomarker of AML. Scientific Reports. Sci Rep. 2015 Jun 12;5:11295.

Javidi-Sharifi N, Traer E, Martinez J, Gupta A, Taguchi T, Dunlap J, Heinrich MC, Corless CL, Rubin BP, Druker BJ, Tyner JW, 2014, Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance, Cancer Res. 2015, 75(5):880-91. PMC4348216

Lal S, Kersch C, Beeson KA, Wu YJ, Muldoon LL, Neuwelt EA.Interactions between αv-Integrin and HER2 and Their Role in the Invasive Phenotype of Breast Cancer Cells In Vitro and in Rat Brain. PLoS One. 2015 Jul 29;10(7):e0131842. doi: 10.1371/journal.pone.0131842. eCollection 2015.

Moren A, Cook M, McClain M, Doberne J, Kiraly L, Perkins RS, Kwong K.A pilot curriculum in international surgery for medical students.J Surg Educ. 2015 Jul-Aug;72(4):e9-e14. doi: 10.1016/j.jsurg.2015.04.027.

Naugler WE, Tarlow BD, Fedorov LM, Taylor M, Pelz C, Li B, Darnell J, Grompe M. Fibroblast growth factor signaling controls liver size in mice with humanized livers. Gastroenterology. 2015 May 28. PMID: 26028580

Siler DA, Berlow YA, Kukino A, Davis M, Nelson J, Grafe M, Ono H, Cetas JS, Pike M, Alkayed NJ. Soluble epoxide hydrolase in hydrocephalus, cerebral edema, and vascular inflammation after subarachnoid hemorrhage. Stroke 2015 Jul;46(7):1916-22. doi: 10.1161/STROKEAHA.114.008560. Epub 2015 May 19. PMCID:  PMC4480190

Stickles AM, Ting L, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, 2015. Nilsen A. Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy. Am J Trop Med Hyg. 2015 pii: 14-0553. [Epub ahead of print] PMID: 25918204.

Stickles AM, Justino de Almeida M, Morrisey JM, Sheridan KA, Forquer IP, Nilsen A, Winter RW, Burrows JN, Fidock DA, Vaidya AB, Riscoe MK. 2015 Subtle changes in endochin-like quinolone structure alter site of inhibition with the cytochrome bc1 complex of Plasmodium falciparum. . Antimicrob Agents Chemother. 2015, 59(4):1977-82. PMC4356778.

Ellison DH, Terker AS, Gamba G.Potassium and Its Discontents: New Insight, New Treatments. J Am Soc Nephrol. 2015 Oct 28. pii: ASN.2015070751. [Epub ahead of print]

Cross CP, Liao S, Urdang ZD, Srikanth P, Garinis AC, Steyger PS. Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure. Int J Pediatr Otorhinolaryngol. 2015 Nov;79(11):1915-9. doi: 10.1016/j.ijporl.2015.09.004. Epub 2015 Sep 9.

Williamson DM, Elferich J, Shinde U. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: Identification of a pH-sensing Histidine Pair in the Propeptide of Proprotein Convertase 1/3.  J Biol Chem. 2015 Jul 30. pii: jbc.M115.665430. [Epub ahead of print] PMID:  26229104

2014 (selected first authors listed only)

Atkins KM, Thomas LL, Barroso-González J, Thomas L, Auclair S, Yin J, Kang H, Chung JH, Dikeakos JD, Thomas G. The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest. Cell Rep. 2014, 8(5):1545-57. PMC4285392.

Doberne JW, Kakaday R, Redd T, Lattin D, Yackel TR, Eriksson CO, Mohan V, Gold JA, Ash JS, Chiang MF. Barriers to Information Access in Electronic Health Records during Initial Patient Visits: A Qualitative Study. Proceedings of the HFES 2015 International Symposium on Human Factors and Ergonomics in Health Care: Improving the Outcomes. 2015 in Press. [Epub ahead of print]

Braun TP, Szumowski M, Levasseur PR, Grossberg AJ, Zhu X, Agarwal A, Marks DL. Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle. PLoS One. 2014 Sep 25;9(9):e106489. doi: 10.1371/journal.pone.0106489. eCollection 2014. PMID:  25254959    [PubMed - in process] 

Magill ST, del Prado G, Chiovaro J. Embolization of hemorrhaging rectus sheath hematoma. J Gen Intern Med. 2014 Feb;29(2):408-9. doi: 10.1007/s11606-013-2579-x. Epub 2013 Sep 4. PMCID:   PMC3912283

Scott GD, Karns CM, Dow MW, Stevens C and Neville HJ (2014). Enhanced peripheral visual processing in congenitally deaf humans is supported by multiple brain regions, including primary auditory cortex. Front. Hum. Neurosci. 8:177. doi: 10.3389/fnhum.2014.00177 - See more at:

Scott GD, Blum ED, Fryer AD, Jacoby DB. Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways. Am J Respir Cell Mol Biol, 2014, 51(1), 43-55. PMC4091855. Selected for journal cover

Siler DA, Gonzalez JA, Wang RK, Cetas JS, Alkayed NJ. Intracisternal administration of tissue plasminogen activator improves cerebrospinal fluid flow and cortical perfusion after subarachnoid hemorrhage in mice.Transl Stroke Res. 2014 Apr;5(2):227-37. doi: 10.1007/s12975-014-0329-y. Epub 2014 Feb 14. PMID:    24526376    [PubMed - in process]

Siler DA, Martini RP, Ward JP, Nelson JW, Borkar RN, Zuloaga KL, Liu JJ, Fairbanks SL, Raskin JS, Anderson VC, Dogan A, Wang RK, Alkayed NJ, Cetas JS. Protective Role of P450 Epoxyeicosanoids in Subarachnoid Hemorrhage.Neurocrit Care. 2014 Sep 18. [Epub ahead of print] PMID:  25231529 [PubMed - as supplied by publisher]

Tarlow BD, Pelz C, Naugler WE, Wakefield L, Wilson EM, Finegold MJ, Grompe M. Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes. Cell Stem Cell. 2014 Oct 8. pii: S1934-5909(14)00399-3. doi: 10.1016/j.stem.2014.09.008. [Epub ahead of print] PMID: 25312494   [PubMed - as supplied by publisher]

Tarlow BD, Finegold MJ, Grompe M.  Clonal tracing of Sox9+ liver progenitors in oval cell injury. Hepatology. 2014 Feb 22. PMID: 24700457.

Terker AS, Yang CL, McCormick JA, Meermeier NP, Rogers SL, Grossmann S, Trompf K, Delpire E, Loffing J, Ellison DH. Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension. Hypertension. 2014 Jul;64(1):178-84. doi: 10.1161/HYPERTENSIONAHA.114.03335. Epub 2014 May 5. PMID: 24799612    [PubMed - indexed for MEDLINE]

Zelaya JE, Goenezen S, Dargon PT, Azarbal A-F, Rugonyi S (2014) Improving the Efficiency of Abdominal Aortic Aneurysm Wall Stress Computations. PLoS ONE 9(7): e101353. doi:10.1371/journal.pone.0101353

2013--pubs more than a year old are only listed if they're first author pubs.

Braun TP, Grossberg AJ, Krasnow SM, Szumowski M, Zhu XX, Levasseur PR, Maxson JE, Barnes AP, Marks DL. (2013) Cancer- and Endotoxin-Induced Cachexia Require Intact Glucocorticoid Signaling in Skeletal Muscle. FASEBJ. 27(9):3572-82. PMCID: PMC3752537

Hornick N and Kurre P. Letting Physiology Guide the Discovery of MicroRNA Regulators of Hematopoiesis. The Hematologist; Jan/Feb 2013. Review.

Riddle A, Maire J, Cai V, Nguyen T, Gong X, Hansen K, Grafe MR, Hohimer AR, Back SA. Hemodynamic and metabolic correlates of perinatal white matter injury severity. PLoS One. 2013 Dec 11;8(12):e82940. doi: 10.1371/journal.pone.0082940. eCollection 2013. PMID:  24416093    [PubMed - indexed for MEDLINE] 

Scott G, Fryer AD, Jacoby DB.  (2012)  Quantifying nerve architecture using three-dimensional computational mapping; application to lung, esophagus, skin and intestine. Am J Respir Cell Mol Biol. 2013  PMCID:PMC3547082[Available on 2014/1/1]

Tormoen GW, Recht O, Gruber A, Levine RL, McCarty OJ. Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells. Phys Biol. 2013 Oct;10(5):056010. doi: 10.1088/1478-3975/10/5/056010. Epub 2013 Oct 8. PMID:  24104188    [PubMed - indexed for MEDLINE] 

Williams-Karnesky RL*, Sandau US*, Lusardi TA*, Lytle NK, Farrell JM, Pritchard EM, Kaplan DL, Boison D. Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis J Clin Invest. 2013; doi:10.1172/JCI65636  PMID:   23863710 [PubMed - as supplied by publisher]

Williamson DM, Elferich J, Ramakrishnan P, Thomas G, Shinde U. The Mechanism by Which a Propeptide-encoded pH Sensor Regulates Spatiotemporal Activation of Furin". J Biol Chem. 2013 Jun 28;288(26):19154-65. doi: 10.1074/jbc.M112.442681. Epub 2013 May 7. PMCID:PMC3696682012

Zachman DK, Leon RP, Das P, Goldman DC, Hamlin KL, Guha C, Fleming WH. Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury. Stem Cell Res. 2013 Nov;11(3):1013-21. doi: 10.1016/j.scr.2013.07.001. Epub 2013 Jul 16. PMID:  23939266


Berlow YA, Pollaro J, Krisky C, Snodgrass M, Kohout K, Lewis MS, Wilmington D, Hutter M, Casiana L, Fitzpatrick M, Lilly DJ, Fausti S, Folmer R, Bourdette D, and Rooney WD.  MRI Correlates of Dichotic Listening Performance in Multiple Sclerosis.  Seminars in Hearing. 2012; 33(3):283-294

Braun TP, Grossberg AJ, Veleva-Rotse BO, Maxson JE, Szumowski M, Barnes AP, Marks DL. Neuronal Expression of Myeloid Differentiation Factor 88 Is Not Requisite for the Induction of Sickness Behavior by Interleukin-1ß. J Neuroinflammation 9(1):229 (2012). PMCID: PMC3488557

Cleary DR, Phillips RS, Wallisch M, Heinricher MM. (2012). A novel, noninvasive method of respiratory monitoring for use with stereotaxic procedures. J.Neurosci. Methods 209(2), 337-343 PMCID:PMC3429636[Available on 2013/8/15]

Mimoto MS, and Christian JL. Friend of GATA (FOG) interacts with the Nucleosome Remodeling and Deacetylase Complex (NuRD) to support primitive erythropoiesis in Xenopus laevis. PLoS One. 2012 Jan;7(1):e29882.

Pratt EB, Zhou Q, Gay JW, Shyng SL. Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels.  August 6 2012, Journal of General Physiology. PMCID: PMC3409095

Riddle A, Maire J, Gong X, Kroenke CD, Hohimer AR, Back SA. Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter lesions. Stroke. 2012 Jan;43(1):178-84. Epub 2011 Nov 10. PMCID:PMC3246543

Su K, Bourdette D, Forte M. Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges. Front Physiol. 2012;3:285. doi: 10.3389/fphys.2012.00285. Epub 2012 Jul 20. PMCID:PMC3401197

Tormoen GW, Cianchetti FA, Bock PE and McCarty OJT (2012) Development of coagulation factor probes for the identification of procoagulant circulating tumor cells. Front. Oncol. 2012; 2: 110(1-12). PMCID: PMC3434442.

Walker JM, Raué HP, Slifka MK. Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole virus vaccine.  Journal of virology 86:13735–13744.  PMC3503040

Dillon SL*, Williamson DM*, Elferich J, Radler D, Joshi R, Thomas G, Shinde U. Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol. 2012 Oct 12;423(1):47-62. doi: 10.1016/j.jmb.2012.06.023. Epub 2012 Jun 25. PMC3444655, *contributed equally.