Danielle Williamson 3MT State Competition

MD/PhD students are involved in a wide variety of research projects across the OHSU campuses. Below are selected recent journal articles by publication year. Student names are in bold.



Doberne JW, Redd T, Lattin D, Yackel TR, Eriksson CO, Mohan V, Gold JA, Ash JS, Chiang MF. Perspectives and Uses of the Electronic Health Record Among US Pediatricians: A National Survey. J Ambul Care Manage. 2017 Jan/Mar;40(1):59-68. PMID: 27902553


Anderson DE, Markway BD, Bond D, McCarthy HE, Johnstone B. Responses to altered oxygen tension are distinct between human stem cells of high and low chondrogenic capacity. Stem Cell Res Ther. 2016 Oct 20;7(1):154. PMID: 27765063 

Deguchi H, Sinha RK, Marchese P, Ruggeri ZM, Zilberman-Rudenko J, McCarty OJ, Cohen MJ, Griffin JH. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va. Blood. 2016 Jul 15. pii: blood-2016-03-707679. [Epub ahead of print] PMID:  27421960 

Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M. Human islets contain four distinct subtypes of β cells.Nat Commun. 2016 Jul 11;7:11756. doi: 10.1038/ncomms11756. PMID: 27399229

Drake MG, Bivins-Smith ER, Proskocil BJ, Nie Z, Scott GD, Lee JJ, Lee NA, Fryer AD, Jacoby DB. Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus.Am J Respir Cell Mol Biol. 2016 Sep;55(3):387-94. doi: 10.1165/rcmb.2015-0405OC.PMID: 27049514 

Ellison DH, Terker AS, Gamba G. Potassium and Its Discontents: New Insight, New Treatments. J Am Soc Nephrol. 2016 Apr;27(4):981-9. doi: 10.1681/ASN.2015070751. Epub 2015 Oct 28. PMID: 26510885 

Feng Z, Jensen SM, Messenheimer DJ, Farhad M, Neuberger M, Bifulco CB, Fox BA Multispectral Imaging of T and B Cells in Murine Spleen and Tumor. J Immunol. 2016 May 1;196(9):3943-50. doi: 10.4049/jimmunol.1502635. Epub 2016 Mar 18.PMID:  26994219

Ferdaus MZ, Barber KW, López-Cayuqueo KI, Terker AS, Argaiz ER, Gassaway BM, Chambrey R, Gamba G, Rinehart J, McCormick JA. SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule. J Physiol. 2016 Apr 12. doi: 10.1113/JP272311. [Epub ahead of print] PMID: 27068441 

Hornick NI, Doron B, Abdelhamed S, Huan J, Harrington CA, Shen R, Cambronne XA, Chakkaramakkil Verghese S, Kurre P. AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB. Sci Signal. 2016 Sep 6;9(444):ra88. doi: 10.1126/scisignal.aaf2797. PMID: 27601730 

Kolahi K, Louey S, Varlamov O, Thornburg K. Real-Time Tracking of BODIPY-C12 Long-Chain Fatty Acid in Human Term Placenta Reveals Unique Lipid Dynamics in Cytotrophoblast Cells.PLoS One. 2016 Apr 28;11(4):e0153522. doi: 10.1371/journal.pone.0153522. eCollection 2016. PMID:  27124483

Lazelle RA, McCully BH, Terker AS, Himmerkus N, Blankenstein KI, Mutig K, Bleich M, Bachmann S, Yang CL, Ellison DH. Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension. J Am Soc Nephrol. 2016 May;27(5):1456-64. doi: 10.1681/ASN.2015040466. Epub 2015 Oct 2. PMID: 26432904 

Liu Y, Wang Z, De La Torre R, Barling A, Tsujikawa T, Hornick N, Hanifin J, Simpson E, Wang Y, Swanzey E, Wortham A, Ding H, Coussens LM, Kulesz-Martin M. Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis. J Invest Dermatol. 2016 Oct 5. pii: S0022-202X(16)32467-8. doi: 10.1016/j.jid.2016.09.020. [Epub ahead of print]PMID:  27720760 

Markway, BD, Cho H, Anderson DE, Holden P, Ravi V, Little CB, Johnstone B, (2016) Reoxygenation enhances tumor necrosis factor alpha-induced degradation of the extracellular matrix produced by chondrogenic cells. European Cells &Materials 31: 425-439. 

Montler R, Bell RB, Thalhofer C, Leidner R, Feng Z, Fox BA, Cheng AC, Bui TG, Tucker C, Hoen H, Weinberg A. OX40, PD-1 and CTLA-4 are selectively expressed on tumor-infiltrating T cells in head and neck cancer. Clin Transl Immunology. 2016 Apr 15;5(4):e70. doi: 10.1038/cti.2016.16. eCollection 2016 Apr. PMID:  27195113 

Priest KC, Lobingier H, McCully N, Lombard J, Hansen M, Uchiyama M, Hagg DS. Expanding Continuous Quality Improvement Capacity in the Medical Intensive Care Unit: Prehealth Volunteers as a Solution.Qual Manag Health Care. 2016 Apr-Jun;25(2):79-84. doi: 10.1097/QMH.0000000000000090. PubMed PMID: 27031356.

Roeder Z, Chen Q, Davis S, Carlson JD, Tupone D, Heinricher MM. Parabrachial complex links pain transmission to descending pain modulation. Pain. 2016 Dec;157(12):2697-2708. PMID:  27657698, PMCID: PMC5113739

Stickles AM, Smilkstein MJ, Morrisey JM, Li Y, Forquer IP, Kelly JX, Pou S, Winter RW, Nilsen A, Vaidya AB, Riscoe MK. Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4853-9. doi: 10.1128/AAC.00791-16. PMID: 27270285 

Sylman JL, Daalkhaijav U, Zhang Y, Gray EM, Farhang PA, Chu TT, Zilberman-Rudenko J, Puy C, Tucker EI, Smith SA, Morrissey JH, Walker TW, Nan XL, Gruber A, McCarty OJ. Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin. Ann Biomed Eng. 2016 Dec 8. [Epub ahead of print] PMID: 27933406 

Tagge I, O'Connor A, Chaudhary P, Pollaro J, Berlow Y, Chalupsky M, Bourdette D, Woltjer R, Johnson M, Rooney W. Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model. PLoS One. 2016 Apr 7;11(4):e0152480. doi: 10.1371/journal.pone.0152480. eCollection 2016. PMID: 27054832 

Terker AS, Zhang C, Erspamer KJ, Gamba G, Yang CL, Ellison DH. Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis. Kidney Int. 2016 Jan;89(1):127-34. doi: 10.1038/ki.2015.289. Epub 2016 Jan 4. PMID:  26422504

Traer E, Martinez J, Javidi-Sharifi N, Agarwal A, Dunlap J, English I, Kovacsovics T, Tyner JW, Wong M, Druker BJ. FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia. Cancer Res. 2016 Sep 26. [Epub ahead of print] PMID: 27671675 

Zhang C, Meermeier NP, Terker AS, Blankenstein KI, Singer JD, Hadchouel J, Ellison DH, Yang CL. Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension. Biochem Biophys Res Commun. 2016 Jan 1;469(1):44-8. doi: 10.1016/j.bbrc.2015.11.067. Epub 2015 Nov 23. PMID: 26607111 

Zhu X, Levasseur PR, Michaelis KA, Burfeind KG, Marks DL. A distinct brain pathway links viral RNA exposure to sickness behavior. Sci Rep. 2016 Jul 20;6:29885. doi: 10.1038/srep29885. PMID: 27435819

Zilberman-Rudenko J, Itakura A, Wiesenekker CP, Vetter R, Maas C, Gailani D, Tucker EI, Gruber A, Gerdes C, McCarty OJ. Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):510-7. doi: 10.1161/ATVBAHA.115.307034. Epub 2016 Jan 14. PMID: 26769048


Selected first authors listed only

Doberne JW, Kakaday R, Redd T, Lattin D, Yackel TR, Eriksson CO, Mohan V, Gold JA, Ash JS, Chiang MF. Barriers to Information Access in Electronic Health Records during Initial Patient Visits: A Qualitative Study. Proceedings of the HFES 2015 International Symposium on Human Factors and Ergonomics in Health Care: Improving the Outcomes. 2015 in Press. [Epub ahead of print]

Ellison DH, Terker AS. Why Your Mother Was Right: How Potassium Intake Reduces Blood Pressure. Trans Am Clin Climatol Assoc. 2015;126:46-55. PMID:  26330658

Feng Z, Puri S, Moudgil T, Wood W, Hoyt CC, Wang C, Urba WJ, Curti BD, Bifulco CB, Fox BA. Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma.J Immunother Cancer. 2015 Oct 20;3:47. doi: 10.1186/s40425-015-0091-z. eCollection 2015.

Hornick N, Huan J, Doron B, Goloviznina N, Lapidus J, Chang B, Kurre P. Serum Exosome MicroRNA as a Minimally-Invasive Early Biomarker of AML. Scientific Reports. Sci Rep. 2015 Jun 12;5:11295.

Javidi-Sharifi N, Traer E, Martinez J, Gupta A, Taguchi T, Dunlap J, Heinrich MC, Corless CL, Rubin BP, Druker BJ, Tyner JW, 2014, Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance, Cancer Res. 2015, 75(5):880-91. PMC4348216

Siler DA, Berlow YA, Kukino A, Davis M, Nelson J, Grafe M, Ono H, Cetas JS, Pike M, Alkayed NJ. Soluble epoxide hydrolase in hydrocephalus, cerebral edema, and vascular inflammation after subarachnoid hemorrhage. Stroke 2015 Jul;46(7):1916-22. doi: 10.1161/STROKEAHA.114.008560. Epub 2015 May 19. PMCID: PMC4480190

Stickles AM, Ting L, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, 2015. Nilsen A. Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy. Am J Trop Med Hyg. 2015 pii: 14-0553. [Epub ahead of print] PMID: 25918204.

Stickles AM, Justino de Almeida M, Morrisey JM, Sheridan KA, Forquer IP, Nilsen A, Winter RW, Burrows JN, Fidock DA, Vaidya AB, Riscoe MK. 2015 Subtle changes in endochin-like quinolone structure alter site of inhibition with the cytochrome bc1 complex of Plasmodium falciparum. . Antimicrob Agents Chemother. 2015, 59(4):1977-82. PMC4356778.

Terker AS, Zhang C, McCormick JA, Lazelle RA, Zhang C, Meermeier NP, Siler DA, Park HJ, Fu Y, Cohen DM, Weinstein AM, Wang WH, Yang CL, Ellison DH. Potassium modulates electrolyte balance and blood presure through effects on distal cell voltage and chloride, Cell Metab. 2015, 21(1):39-50. PMC4332769. 

Terker AS, Yarbrough B, Ferdaus MZ, Lazelle RA, Erspamer KJ, Meermeier NP, Park HJ, McCormick JA, Yang CL, Ellison DH. Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport. J Am Soc Nephrol. 2015 Dec 28. pii: ASN.2015070815. [Epub ahead of print] PMID: 26712527

Williamson DM, Elferich J, Shinde U. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: Identification of a pH-sensing Histidine Pair in the Propeptide of Proprotein Convertase 1/3. J Biol Chem. 2015 Jul 30. pii: jbc.M115.665430. [Epub ahead of print] PMID: 26229104


Selected first authors listed only

Atkins KM, Thomas LL, Barroso-González J, Thomas L, Auclair S, Yin J, Kang H, Chung JH, Dikeakos JD, Thomas G. The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest. Cell Rep. 2014, 8(5):1545-57. PMC4285392.

Doberne JW, Kakaday R, Redd T, Lattin D, Yackel TR, Eriksson CO, Mohan V, Gold JA, Ash JS, Chiang MF. Barriers to Information Access in Electronic Health Records during Initial Patient Visits: A Qualitative Study. Proceedings of the HFES 2015 International Symposium on Human Factors and Ergonomics in Health Care: Improving the Outcomes. 2015 in Press. [Epub ahead of print]

Braun TP, Szumowski M, Levasseur PR, Grossberg AJ, Zhu X, Agarwal A, Marks DL. Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle. PLoS One. 2014 Sep 25;9(9):e106489. doi: 10.1371/journal.pone.0106489. eCollection 2014. PMID: 25254959   [PubMed - in process] 

Magill ST, del Prado G, Chiovaro J. Embolization of hemorrhaging rectus sheath hematoma. J Gen Intern Med. 2014 Feb;29(2):408-9. doi: 10.1007/s11606-013-2579-x. Epub 2013 Sep 4. PMCID:  PMC3912283

Scott GD, Karns CM, Dow MW, Stevens C and Neville HJ (2014). Enhanced peripheral visual processing in congenitally deaf humans is supported by multiple brain regions, including primary auditory cortex. Front. Hum. Neurosci. 8:177. doi: 10.3389/fnhum.2014.00177
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Scott GD, Blum ED, Fryer AD, Jacoby DB. Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways. Am J Respir Cell Mol Biol, 2014, 51(1), 43-55. PMC4091855. Selected for journal cover

Siler DA, Gonzalez JA, Wang RK, Cetas JS, Alkayed NJ. Intracisternal administration of tissue plasminogen activator improves cerebrospinal fluid flow and cortical perfusion after subarachnoid hemorrhage in mice.Transl Stroke Res. 2014 Apr;5(2):227-37. doi: 10.1007/s12975-014-0329-y. Epub 2014 Feb 14. PMID:   24526376   [PubMed - in process]

Siler DA, Martini RP, Ward JP, Nelson JW, Borkar RN, Zuloaga KL, Liu JJ, Fairbanks SL, Raskin JS, Anderson VC, Dogan A, Wang RK, Alkayed NJ, Cetas JS. Protective Role of P450 Epoxyeicosanoids in Subarachnoid Hemorrhage.Neurocrit Care. 2014 Sep 18. [Epub ahead of print] PMID: 25231529 [PubMed - as supplied by publisher]

Tarlow BD, Pelz C, Naugler WE, Wakefield L, Wilson EM, Finegold MJ, Grompe M. Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes. Cell Stem Cell. 2014 Oct 8. pii: S1934-5909(14)00399-3. doi: 10.1016/j.stem.2014.09.008. [Epub ahead of print] PMID: 25312494  [PubMed - as supplied by publisher]

Tarlow BD, Finegold MJ, Grompe M. Clonal tracing of Sox9+ liver progenitors in oval cell injury. Hepatology. 2014 Feb 22. PMID: 24700457.

Terker AS, Yang CL, McCormick JA, Meermeier NP, Rogers SL, Grossmann S, Trompf K, Delpire E, Loffing J, Ellison DH. Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension. Hypertension. 2014 Jul;64(1):178-84. doi: 10.1161/HYPERTENSIONAHA.114.03335. Epub 2014 May 5. PMID: 24799612   [PubMed - indexed for MEDLINE]

Zelaya JE, Goenezen S, Dargon PT, Azarbal A-F, Rugonyi S (2014) Improving the Efficiency of Abdominal Aortic Aneurysm Wall Stress Computations. PLoS ONE 9(7): e101353. doi:10.1371/journal.pone.0101353


Selected first authors listed only

Braun TP, Grossberg AJ, Krasnow SM, Szumowski M, Zhu XX, Levasseur PR, Maxson JE, Barnes AP, Marks DL. (2013) Cancer- and Endotoxin-Induced Cachexia Require Intact Glucocorticoid Signaling in Skeletal Muscle. FASEBJ. 27(9):3572-82. PMCID: PMC3752537

Hornick N, Kurre P. Letting Physiology Guide the Discovery of MicroRNA Regulators of Hematopoiesis. The Hematologist;Jan/Feb 2013. Review.

Riddle A, Maire J, Cai V, Nguyen T, Gong X, Hansen K, Grafe MR, Hohimer AR, Back SA. Hemodynamic and metabolic correlates of perinatal white matter injury severity. PLoS One. 2013 Dec 11;8(12):e82940. doi: 10.1371/journal.pone.0082940. eCollection 2013. PMID: 24416093   [PubMed - indexed for MEDLINE] 

Scott GD, Fryer AD, Jacoby DB. (2012) Quantifying nerve architecture using three-dimensional computational mapping;application to lung, esophagus, skin and intestine. Am J Respir Cell Mol Biol. 2013 PMCID:PMC3547082[Available on 2014/1/1]

Tormoen GW, Recht O, Gruber A, Levine RL, McCarty OJ. Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells. Phys Biol. 2013 Oct;10(5):056010. doi: 10.1088/1478-3975/10/5/056010. Epub 2013 Oct 8. PMID: 24104188   [PubMed - indexed for MEDLINE] 

Williams-Karnesky RL*, Sandau US*, Lusardi TA*, Lytle NK, Farrell JM, Pritchard EM, Kaplan DL, Boison D. Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis J Clin Invest. 2013;doi:10.1172/JCI65636 PMID:  23863710 [PubMed - as supplied by publisher]

Williamson DM, Elferich J, Ramakrishnan P, Thomas G, Shinde U. The Mechanism by Which a Propeptide-encoded pH Sensor Regulates Spatiotemporal Activation of Furin". J Biol Chem. 2013 Jun 28;288(26):19154-65. doi: 10.1074/jbc.M112.442681. Epub 2013 May 7. PMCID:PMC3696682012

Zachman DK, Leon RP, Das P, Goldman DC, Hamlin KL, Guha C, Fleming WH. Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury. Stem Cell Res. 2013 Nov;11(3):1013-21. doi: 10.1016/j.scr.2013.07.001. Epub 2013 Jul 16. PMID: 23939266


Selected first authors only.

Berlow YA, Pollaro J, Krisky C, Snodgrass M, Kohout K, Lewis MS, Wilmington D, Hutter M, Casiana L, Fitzpatrick M, Lilly DJ, Fausti S, Folmer R, Bourdette D, and Rooney WD.  MRI Correlates of Dichotic Listening Performance in Multiple Sclerosis.  Seminars in Hearing. 2012; 33(3):283-294

Braun TP, Grossberg AJ, Veleva-Rotse BO, Maxson JE, Szumowski M, Barnes AP, Marks DL. Neuronal Expression of Myeloid Differentiation Factor 88 Is Not Requisite for the Induction of Sickness Behavior by Interleukin-1ß. J Neuroinflammation 9(1):229 (2012). PMCID: PMC3488557

Cleary DR, Phillips RS, Wallisch M, Heinricher MM. (2012). A novel, noninvasive method of respiratory monitoring for use with stereotaxic procedures. J.Neurosci. Methods 209(2), 337-343 PMCID:PMC3429636[Available on 2013/8/15]

Mimoto MS, and Christian JL. Friend of GATA (FOG) interacts with the Nucleosome Remodeling and Deacetylase Complex (NuRD) to support primitive erythropoiesis in Xenopus laevis. PLoS One. 2012 Jan;7(1):e29882.

Pratt EB, Zhou Q, Gay JW, Shyng SL. Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels.  August 6 2012, Journal of General Physiology. PMCID: PMC3409095

Riddle A, Maire J, Gong X, Kroenke CD, Hohimer AR, Back SA. Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter lesions. Stroke. 2012 Jan;43(1):178-84. Epub 2011 Nov 10. PMCID:PMC3246543

Su K, Bourdette D, Forte M. Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges. Front Physiol. 2012;3:285. doi: 10.3389/fphys.2012.00285. Epub 2012 Jul 20. PMCID:PMC3401197

Tormoen GW, Cianchetti FA, Bock PE and McCarty OJT (2012) Development of coagulation factor probes for the identification of procoagulant circulating tumor cells. Front. Oncol. 2012; 2: 110(1-12). PMCID: PMC3434442.

Walker JM, Raué HP, Slifka MK. Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole virus vaccine.  Journal of virology 86:13735–13744.  PMC3503040

Dillon SL*, Williamson DM*, Elferich J, Radler D, Joshi R, Thomas G, Shinde U. Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol. 2012 Oct 12;423(1):47-62. doi: 10.1016/j.jmb.2012.06.023. Epub 2012 Jun 25. PMC3444655, *contributed equally.