MD/PhD Journal Club

MD-PhD Journal Club presentations

Journal club is a mixture of Faculty Grand Rounds presentations and student presented journal clubs. Journal club is on Wednesdays at noon in Mackenzie Hall. Guidelines for presentations are available here.

Below is a schedule of upcoming presentations, at the bottom is a list of past presentations. (Students are listed by first name only.) Where possible, articles are linked to their source.

February 14,

February 21, Jackie

February 28, Katy

March 7, Dr. Bita Moghaddam, Behavioral Neuroscience

March 14, Jenya

March 21, Gavin

March 28, Burcu

April 4, Ali

April 11, Cymon

April 18, Dr. Carsten Schultz, Physiology & Pharmacology

April 25, Katie

May 2, Dr. Kelly Monk, Vollum Institute

May 9, Anjali

May 16, Cheryl

May 23, Kevin B.

June 6, Dr. Alejandro Aballay, Molecular Microbiology and Immunology

June 13, Caroline

Completed Presentations

February 7, Dr. Mary Heinricher, Neurology, Light: A window into pain in the brain

January 31, Tony, Accelerating bacterial growth detection and antimicrobial susceptibility assessment in integrated picoliter droplet platform,

January 24, Sam, Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

January 17, Jim, Stress-induced unfolded protein response contributes to Zika virus–associated microcephaly,

January 10, Rachel, Transcription Factor EB Controls Metabolic Flexibility during Exercise,

January 3, Dr. Marc Freeman, Vollum Institute, Molecular mechanisms of axon degeneration

Dec 20, Cheryl, 3D Collagen Architecture and vasculogenic mimicry,

Dec 13, Anjali, iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury commentary

Dec 6, Dr. David Bangsberg, Dean School of Public Health, International perspectives on adherence to hiv prevention and treatment

November 29, Brennan, In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

November 15, Mike, Unique approaches to restoration of patterned vision using optogenetic gene therapy

November 8, Gina, Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR−/− mouse model of atherosclerosis,

November 1, H. Scott Stadler, Skeletal Biology, Role of long non coding RNAs in cartilage and genitourinary development

October 25, TheAnh, Macrophages Facilitate Electrical Conduction in the Heart

October 18, Kristen, Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

October 11, Katy, GFRAL and GDF15: roles in cachexia and obesity. Articles: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15, and GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

October 4, Dr. Agnieszka Balkowiec, Integrative Biosciences, Novel Approaches to Understanding Mechanisms of Craniofacial Pain: Focus on Proinflammatory Cytokines and Neurotrophic Factors

September 27, Sweta, Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction

September 20, Kelsey, Protecting unauthorized immigrant mothers improves their children's mental health

September 13, Kevin B,  Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility

September 6, Dr. Reid Thompson, Radiation Oncology, Cancer Immunotherapy Genomics

August 30, Dr. David Jacoby, Welcome new students, How to give a good journal club.

August 23, Sudarshan, BET Bromodomain Proteins Function as Master Transcription Elongation Fastors Independent of DCK9 Recruitment,

August 16, Nichole, Fasting-Mimicking Diet Promotes Ngn3-Driven Β-Cell Regeneration to Reverse Diabetes

August 9, John, Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

August 2, Cymon A soft robotic exosuit improves walking in patients after stroke

July 26, Sunil, SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer,

July 19, Mollie, Neural correlates of maintaining one's political beliefs in the face of counter evidence,

July 12, Tomo Ito and Matthew Rempes--Demystifying the MD lottery process  

June 21, Katie, Bumblebee family lineage survival is enhanced in high-quality landscapes

June 14, Elizabeth, New Persistent Opioid Use After Minor and Major Surgical Procedures in US Adults,

June 7, Dr. Steven Mansoor, Cardiology, How structural biology can impact cardiovascular medicine: P2X receptor from sequence to structure

May 31, Ali, History-dependent variability in population dynamics during evidence accumulation in cortex

May 24, Jenya, A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo.

May 17, TheAnh, Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling

May 10, Katy, S100-alarmin-induced innate immune programming protects newborn infants from sepsis

May 3, Dr. Jim McCormick, Nephrology, Ubiquitin Ligase-mediated Regulation of Blood Pressure and Potassium Homeostasis

April 26, Dr. Honora Englander, Developing and Implementing Addiction Medicine Consultation (IMPACT) at OHSU

April 19, Rachel, Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation,

April 12, Sam, Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

April 5, Cheryl, Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression.

March 29, Andy, Danielle, Noah, Dominic Tales from the Residency Trail

March 22, Sweta, A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins

March 15, Gina, Disrupted iron regulation in the brain and periphery in cocaine addiction

March 8, Mike, How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina

March 1, Dr. Julia Maxson, Hematology and Medical Oncology, Genomically guided targeted therapeutics in myeloid leukemia

February 22, Brennan, CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

February 15, Kelsey Methadone continuation versus forced withdrawal on incarceration in a combined US prison and jail: a randomised, open-label trial.

February 8, Jim, Gamma frequency entrainment attenuates amyloid load and modifies microglia

February 1, Dr. Amanda McCullough, Oregon Institute of Occupational Health Sciences, DNA Repair Strategies for Prevention and Treatment of Cancer

January 25, Kevin B. Origin, fate, and dynamics of macrophages at central nervous system interfaces

January 18, Anjali, Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

January 4, Dr. Richard Mullins, Trauma Surgery, Development of the Starr Edwards prosthetic heart valves

December 14, Zach, Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

December 7, Dr. Shannon McWeeney, DMICE, Reproducibility or Bust: What Everyone Needs to Know and Do

November 30, Kristen, Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder.

November 16, Sunil, Improved i.p. drug delivery with bioadhesive nanoparticles

November 9, Nichole, Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein And an associated news article about it:

October 26, Jenya, Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

October 19, Mollie, Do Early Educators' Implicit Biases Regarding Sex and Race Relate to Behavior Expectations and Recommendations of Preschool Expulsions and Suspensions?

October 12, Elizabeth,Targeted Fibrillar Nanocarbon RNAi Treatment of Acute Kidney Injury

October 5, Dr. Miranda Lim, Pulmonary & Critical Care, The role of sleep in the pathogenesis of autism spectrum disorder: Lessons from the social prairie vole

September 28, Sudarshan, Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation

September 21, John, The Rel/NF-κB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity.

September 14, Zip, Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy

September 7, Kevin, Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model

August 31, MD/PhD Orientation, David Jacoby--How to give a journal club

August 24, Katie, Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children,

August 17, Cymon, Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer,

August 10, Jim, Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature

August 3, Dr. Sophia Bornstein, Radiation Oncology, Novel prognostic and predictive strategies in head and neck and lung cancer

July 27, Ali Sex Differences in Physician Salary in US Public Medical Schools

July 20, Rachel, Asprosin, a Fasting-Induced Glucogenic Protein Hormone,

July 13, Sam, Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.

July 6, Cheryl, Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response

June 29, Jenya, FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow

June 22, Katy, Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial

June 15, Devon, Dissertation presentation: Scaffold-free tissue engineering for articular cartilage repair

June 8, Anjali, Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression

June 1, Dr. Pepper Schedin, Cell & Developmental Biology, Pregnancy Related Breast Cancer Metastasis

May 25, Nathalie, Two related articles: Description Of Two Mouse Models Of Placental Zika Virus Infection How IFNgamma1 May Protect Placental Trophoblasts From Zika Virus Infection

May 18, Johanna, Challenging Questions

May 11, Kevin B. Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice

April 27, Q, On sensitization of a brainstem pain-modulating circuit during persistent pain.

April 20, Elizabeth,TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma.

April 13, Dr. Raymond Bergan, Hematology/Oncology, Therapeutically Targeting Cancer Cell Motility

April 6, Zach, Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

March 30, Sunil, Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells

March 23, Kelsey, Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial

March 16, Nichole, Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes,

March 9, Zip, Mastering the game of Go with deep neural networks and tree search

March 2, Dr. Molly Kulesz-Martin, Dermatology, Precision medicine approaches in dermatology: squamous cell carcinoma and inflammation

February 24, Mollie,The Dissociative Subtype of Posttraumatic Stress Disorder: Unique Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes

February 17, Sudarshan, Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

February 10, Dr. Nathalie Pamir, Research Assistant Professor, Knight Cardiovascular Institute, Is there something else to HDL than HDL cholesterol?

February 3, Charlie, Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

January 27, Kevin K, Rescuing US biomedical research from its systemic flaws

January 20, John, Translating dosage compensation to trisomy 21

January 13, Kristen, Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder, Additional related articles: Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans,     Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals,

January 6, Dr. Monica Hinds, Biomedical Engineering, Bioactive biomaterials for cardiovascular applications

End of 2015

December 16, Cymon, Two articles Structural and functional features of central nervous system lymphatic vessels Article: and A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

December 9, Ali, Human mutant huntingtin disrupts vocal learning in transgenic songbirds

December 2, Dr. Michael Cohen, Physiology & Pharmacology,Decoding Protein ADP-ribosylation Networks in Cells Using Chemical Genetic Approaches

November 4, Dr. Summer Gibbs, Biomedical Engineering, Novel Fluorescent Contrast for Macroscopic and Microscopic Cancer Imaging

October 28, Katie L. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4.

October 21, Nathalie, An ultrathin invisibility skin cloak for visible light

October 14, Devon, Identification of a Prg4-Expressing Articular Cartilage Progenitor Cell Population in Mice

October 7, Dr. Garet Lahvis, Behavioral Neuroscience, Social Neuroscience: Social Mind, Emotional Mind, in Mice and Humans

September 30, Sam, CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes (Liang et al. 2015)

September 23, Rachel, Mitochondrial oxidative stress promotes atrial fibrillation

September 16, Anjali, The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways

September 9, Jenya,Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial.

September 2, Dr. Bonnie Nagel, Clinical Psychology, The chicken or the egg: Distinguishing between neurobiological markers of risk for versus consequences of adolescent drinking.

August 26, David Jacoby, Introductions and Presenting at Journal Club

August 19, Q, Nociceptive Sensitization Reduces Predation Risk,

August 12, Zach, Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood–CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases

August 5, Katy M, Host microbiota constantly control maturation and function of microglia in the CNS

July 29, Kevin B. Pharmacological chaperones stabilize retromer to limit APP processing

July 22, cancelled

July 15, Elizabeth, Integrated compensatory network is activated in the absence of NCC phosphorylation

July 8, Derek, 100 years of General Relativity Theory, Article: info

July 1, no journal club.

June 24, Noah, An enigmatic plant-eating theropod from the Late Jurassic period of Chile,

June 17, Danielle, Propeptides and pH sensing in Proprotein Convertase 1/3

June 10, Residency Director's Panel, Dr Cindy Ferrell (Pediatrics), Dr. Karen Brasel (Surgery), Dr. Timur Mitin, Dr. Mark Wax, Otolaryngology

June 3, Dr. Sudarshan Anand, Cell and Developmental Biology, MicroRNA mediated inhibition of DNA repair as an anti-angiogenic strategy

May 27, Kelsey, The Oregon Experiment--Effects of Medicaid on Clinical Outcomes,

May 20, Greg, Rebecca and Garth: Tales from Residency Road

May 13, Charlie, A CXCL1 paracrine network links cancer chemoresistance and metastasis

May 6, Dr. Brian Johnstone, Orthopedics, Hypoxia inducible factors and cartilage regeneration

April 29, Cymon, Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

April 22, Devon, Anticrack nucleation as triggering mechanism for snow slab avalanches

April 15, Dr. Peter Kurre, Stem Cell Center, Regulation of hematopoietic activity by "platelet dust"

April 8, Kevin K. Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

April 1, Zip, Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack.

March 25, Jenya, Live-cell imaging of invasion and intravasation in an artificial microvessel platform,

March 18, Katie L. A new antibiotic kills pathogens without detectable resistance

March 11, Cheryl, Cancer-Associated Protein Kinase C Mutations Reveal Kinase's Role as Tumor Suppressor

March 4, Dr. Gail Mandel, Neuroscience, Recent Approaches For Understanding And Thinking About Cures For The Neurological Disease, Rett Syndrome

February 25, Anjali An ancient defense system eliminates unfit cells from developing tissues during cell competition URL:

February 18, Ali, Microstructure of a spacial map in the entorhinal cortex.

February 11, Julie, Identifying phenotypic signatures of neuropsychiatric disorders from electronic medical records,

February 4, Sam, Perceptual relearning of complex visual motion after V1 damage in humans (Huxlin et al, 2009)

January 28, Rachel, Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation,

January 21, Jim, Foretinib is effective therapy for metastatic Sonic Hedgehog medulloblastoma

January 14, Dr. Shannon McWeeney, Biostatistics and Bioinformatics, Data tells a Story: Visual and Statistical Thinking for Translational Study Designs

January 7, Nathalie, Tracking cancer drugs in living cells by thermal profiling of the proteome

End 2014

December 17, Katy M. CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

December 10, Kristen, An enteric virus can replace the beneficial function of commensal bacteria,

December 3, Dr. Bill Rooney, Advanced Imaging Research Center, Quantitative Magnetic Resonance Imaging and Spectroscopy at High Magnetic Field: Insights into Cerebral Metabolism

November 19, Danielle, Life cycles, fitness decoupling and the evolution of multicellularity.

November 12, Derek Paleomagnetic and tephra evidence for tens of Missoula floods in southern Washington,

November 5, Dr. Larisa Tereshchenko, Cardiology, Risk stratification of sudden cardiac death in the general population of asymptomatic adults

October 29, Noah, The genetics of monarch butterfly migration and warning colouration, URL:

October 22, Dr. Jamie Lee, Professor at Mayo Arizona, Fifty Shades of Eosin: The Hidden Role of Eosinophils in Bladder Cancer

October 15, Elizabeth, Pulmonary macrophage transplantation therapy URL:

October 8, Dr.  Bill Chang,  Pediatric Hematology, Bill Chang's Road to Physician-Scientist.  Personalized pathway to personalized medicine

October 1, Q, Retreat Keynote Presentation: Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor,

September 24, Kevin B. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 URL:

September 17, Johanna, Challenging Questions--Leadership development

September 10, Zach, Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear

September 3, David Jacoby, Orientation, program welcome

August 27, Jenya, Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts, URL:

August 20, Charlie, Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes,

August 13, Katie L. Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

August 6, Dr. Jeff Gold, Director of Simulation Center,  A scientific approach to EHR usability

July 30, Cheryl, Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia".

July 23, Anjali, Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

July 16, Cymon, Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells,

July 9, Zip, In Vivo–Generated Antigen-Specific Regulatory T Cells Treat Autoimmunity Without Compromising Antibacterial Immune Response

June 25, QiLiang, Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds.

June 18, Devon, TGF-β Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

June 11, Kevin K. Autophagy regulates adipose mass and differentiation in mice

June 4, Dr. Scott Naugler, Gastroenterology, Why does the liver regenerate?

May 28, Residency Director's Panel: Dr. Alan Hunter, Internal Medicine; Dr. Mark Kinzie, Psychiatry; Dr. Cindy Ferrell, Pediatrics;  Dr. Paul Flint, Otolaryngology; Dr. Timur Mitin, Radiation Oncology; Dr. Sancy Leachman, Dermatology; Dr. Christopher Swide, Anesthesiology;

May 21, Jaime, Improving the Efficiency of Abdominal Aortic Aneurysm Wall Stress Computations

May 14, Julie, What Makes a Visualization Memorable?

May 7, 2014, Dr George Thomas, Pathology,  Targeted Therapies for Non-Clear Cell Kidney Cancer

April 30, Ted, et al, Residency Interview Trail

April 23, Danielle, High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation"

April 16, Dan, Avoiding Burnout, and

April 9, Zach, Stimulus-triggered fate conversion of somatic cells into pluripotency,

April 2, Dr. Miranda Lim, Sleep Medicine, Sleep disturbances after traumatic brain injury

March 26, Andy, Low dietary potassium directly activates the sodium chloride cotransporter to cause hypertension

March 19, Dominic, Munchausen syndrome: a novel cause of drug-resistant hypertension,

March 12, Derek, In Situ Observations of Interstellar Plasma with Voyager 1

March 5, Dr. Fay Horak, Neurology, Physiology and Biomedical Engineering, Parkinson's disease:  Motor and Cognitive Locomotor Dysfunction

February 26, Katy M., Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

February 19, Elizabeth, XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity,

February 12, Kristen, Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching

February 5, Dr. David Jacoby, Mentorship

January 29, Kevin B. Imaging local neuronal activity by monitoring PO2 transients in capillaries URL:

January 22, Nathalie Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression. URL:,  will also include  and  which are studies that lead up to this.

January 15, 2014, Dr. Shiuh-Wen Luoh, Knight Cancer Inst. Chromosome 17q11-12 amplification in breast cancer

January 8, Cymon, Targeting a Dual Detector of Skin and CO2 to Modify Mosquito Host Seeking

End 2013

December 18, Branden, A Controlled Trial of Gluten-Free Diet in Patients With Irritable BowelSyndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function,

December 11, Jenya, Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.

December 4, Dr. Stephen Back, Pediatric Neuroscience, Brain Injury in the Premature Infant: Unexpected Mechanisms of Dysmaturation, Regeneration and Repair

November 20, Anjali, Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1? and sterile vascular inflammation in atherosclerosis

November 13, Kevin K.,  Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation URL:

November 6, Dr. Sancy Leachman, Dermatology Melanoma Prevention Update

October 23, Devon High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

October 16, Cheryl, Nontoxic radioactive listeria is a highly effective therapy against metastatic pancreatic cancer,

October 9, Dr. Dan Marks, Pediatrics, Central Mechanisms in Cachexia

October 2, Derek, Effects of human eosinophil granule-derived cationic proteins on C-fiber afferents in the rat lung,

September 25, Charlie Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

September 18, Katie L.,  Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

September 11, Zip, Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

September 4, Dr. David Jacoby, Welcome students, introductions, journal club expectations and best practices

August 28, Danielle, Betatrophin: A Hormone that Controls Pancreatic ß Cell Proliferation

August 21, Branden, In vitro expansion of single Lgr5(+) liver stem cells induced by Wnt-driven regeneration,

August 14, Q, Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-ß

August 7, Dr. Wassana Yantasee, Biomedical Engineering, Nanoparticle platforms for targeted delivery of siRNA and chemotherapies

July 31, Jaime, Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse URL:

July 24, Zach, Genomic responses in mouse models poorly mimic human inflammatory diseases URL:

July 17, Julie, Web-scale pharmacovigilance: Listening to signals from the crowd.

July 10, Derek; 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.

June 26, 2013 Allison, Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System

June 19, 2013 Andy, Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPAR and RhoA/Rho-Kinase

June 12, 2013 Dominic, Early Cortical Hypoperfusion after Subarachnoid Hemorrhage

June 5, 2013 Yossi, Iron, Methamphetamine and Cigarettes

May 29, 2013 Johanna Colgrove, Documentation Preparation--Mastering Word

May 22, 2013 Jenya, Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells

May 15, 2013 Greg, Novel airway imaging applied to neuroimmune interactions in asthma

May 8, 2013 Garth, New Thoughts on Old Blood Clots

May 1, 2013 Dr. James Tanyi, Radiation Medicine, A pilot study on the use of DCE-MRI in the prediction of head and neck cancer response to chemoradiation

April 24, 2013 Charlie, Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

April 17, 2013 Devon, Identifying Personal Genomes by Surname Inference

April 10, 2013 Zip, Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice URL:

April 3, 2013 Dr.s Kristina Young M.D., Ph.D. and Sophia Bornstein M.D., Ph.D. Sophia: Tumor-Initiating Cell Microenvironment in Head and Neck Squamous Cell Carcinoma, Kristina: Targeted Alteration of the Tumor Immune Environment to Increase Chemoradiosensitivity in Rectal Cancer Together: transitioning from MD/PhD to residency and beyond

March 20, 2013 Cheryl MYC Suppresses Cancer Metastasis by Direct Transcriptional Silencing of av and ß3 Integrin Subunits

March 13, 2013 Kevin, Diagnostic Inaccuracy of Smartphone Applications for Melanoma Detection

March 6, 2013 Cymon, Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes

February 27, 2013 Katie L., Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

February 20, 2013 Anjali, The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

February 6 2013 Dr Bob Hitzemann, Behavioral Neuroscience, Systems Biology, Gene Networks and Behavior

January 30, 2013 Rebecca W. Adult hippocampal neurogenesis buffers stress response and depressive behavior,

January 23, 2013 Dominic, A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid?

January 16, 2013 Noah, CCR5 is a receptor for Staphylococcus aureus leukotoxin ED

January 9, 2013 Dr. Landon King, Pulmonary & Critical Care Medicine, Vice Dean for Research, Johns Hopkins University, Acute Respiratory Distress Syndrome:  Be It Hereby Resolved...

January 2, 2013 Dr. Lina Reiss, Otolaryngology, Pitch plasticity and binaural spectral integration with cochlear implants

End of 2012

December 19, 2012 Garth, Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo,

December 12, 2012 Dr. Leslie Kahl, MD Curriculum Reform December 5, Dr. Mary Kelley, Casey Eye Institute Restoration of the Trabecular Meshwork by Stem Cells

November 28, 2012 Branden, Cells keep a memory of their tissue origin during axolotl limb regeneration

November 14, 2012 Danielle, Mechanistic implications for LDL receptor degredation from the PCSK9/LDLR structure at neutral pH

November 7, 2012 Dr. Hiroyuki Nakai, M.D., Ph.D., Molecular & Medical Genetics, AAV vectors in gene therapy

October 31, 2012 Yossi, Dopaminergic neurons inhibit striatal output through non-canonical release of GABAURL:

October 24, 2012 Zach, Photochemical Restoration of Visual Responses in Blind Mice,

October 17, 2012 QiLiang, Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress

October 10, 2012 Zipei, PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain.

October 3, 2012 Dr. Tom Scanlan, Physiology & Pharmacology, Discovery and Development of Sobetirome—a Selective Thyroid Hormone Analog

September 26, 2012 Andy, Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

September 19, 2012 Devon, A Stem Cell-Based Approach to Cartilage Repair

September 12, 2012 Jaime, New insights into the role of VIP on the ratio of T-cell subsets during the development of autoimmune diabetes.

September 5, 2012 Dr. Megan Troxell, Translational Breast Pathology

August 29, 2012 Dr. David Jacoby, Welcome students introductions, journal club expectations and best practices

August 22, 2012 Derek, Leukemia-stimulated bone marrow endothelium promotes leukemia cell survival:

August 15, 2012 Charlie, Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

August 8, 2012 Kevin, Cell Lineage Analysis of the Mammalian Female Germline

August 1, 2012 Dr. Jon Purnell, Endocrinology, "Human Knockouts: Using rare disorders of fatty acid oxidation to explore the cause of insulin resistance."

July 25, 2012 Andy, Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.

July 18, 2012 Julie, Long-term use of a left ventricular assist device for end stage heart failure

July 11, 2012 Allison, Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery

June 20, 2012 Becky, The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain"

June 13, 2012 Ted, mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

June 6, 2012 Dr. Terry Morgan, Pathology and OB/Gyn, Fetal programming of white coat hypertension in growth restricted mice

May 30, 2012 Garth, Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia,

May 23 Dominic, SKCa and IKCa Channels, Myogenic Tone, and Vasodilator Responses in Middle Cerebral Arteries and Parenchymal Arterioles,

May 16, 2012 Miz & Doran (with special guests), Reflections on the Residency Interview Road

May 9, Noah, Interactions between cancer stem cells and their niche govern metastatic colonization,

May 2, Dr. Robert O'Rourke, Surgery,  Inflammation and Immunity in Obesity and Metabolic Disease

April 25, 2012 Derek,  Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum,

April 18, 2012 Zach, Adolescent development of psychosis as an outcome of hearing impairment: a 10-year longitudinal study,

April 11, 2012, Branden, Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

April 4, 2012, Jon D. Hennebold, Ph.D. Div. of Reproductive Sciences, The Search for Non-Hormonal Female Contraceptives: A Molecular Approach

March 21, 2012, Devon, Regeneration and Orthotopic Transplantation of a Bioartificial Lung,

March 14, 2012, Dr. Joe Gray, Department of Biomedical Engineering, Increasing the Precision With Which We Treat  Breast Cancer

March 7, 2012, Charlie, Inflammation and proliferation act together to mediate intestinal cell fusion,

February 29, 2012, Zipei,  "A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis"

February 22, 2012, Danielle, In Vitro and In Vivo Studies Identify Important Features of Dengue Virus pr-E Protein Interactions

February 15, 2012, Kevin,  Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos";2/66/ra16

February 8, 2012, QiLiang, Environmentally induced antinociception and hyperalgesia in rats and mice,

February 1, 2012,  Dr. Joshi Alumkal, Oncology, Advances in Prostate Cancer Treatment: Lessons Learned

January 25, 2012, Katie, A novel retinoblastoma therapy from genomic and epigenetic analyses"

January 18, 2012, Dan, Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children

January 11, 2012, Yossi Binaural auditory processing in multiple sclerosis subjects

January 4, 2012, Dr. Mary Stenzel-Poore, Ph.D. Molecular Microbiology & Immunology Unleashing the Brain's Endogenous Neuroprotective Strategies Through Toll-like Receptors

End of 2011

December 14, 2011, Allison, The ageing systemic milieu negatively regulates neurogenesis and cognitive function

December 7, 2011, Dr. Mary Heinricher, Behavioral Neuroscience, "How the Brain Controls Pain"

November 30, 2011, Greg, Superresolution Imaging of Chemical Synapses in the Brain"

November 16, 2011, Andy, K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

November 9, 2011, Garth, "Tumor Self-Seeding by Circulating Cancer Cells"  Also, an editorial summarizing the main findings:

November 2, 2011, Dr. Michael Hutchens, Sex and Perioperative Acute Kidney Injury

October 26, 2011, Art two related articles: A Small-Molecule Smoothened Agonist Prevents Glucocorticoid-Induced Neonatal Cerebellar Injury  Preterm Cerebellar Growth Impairment After Postnatal Exposure to Glucocorticoids

October 19, 2011, Rebecca W.,  Erroneous analyses of interactions in neuroscience: a problem of significance

October 12, 2011, Derek, Regulation of the HIF-1a Level Is Essential for Hematopoietic Stem Cells"

October 5, 2011, Dr. Debbie Lewinsohn, M.D. Pediatrics, Lessons learned from primary infection with M. tuberculosis

September 28, 2011, Jaime, A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories,

September 21, 2011, Zach, Vascular anastomosis using controlled phase transition in poloxamer gels,

September 14, 2011, Dominic, Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress

September 21, 2011, Zach, Vascular anastomosis using controlled phase transition in poloxamer gels,

September 14, 2011, Dominic, Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-?

September 7, 2011, Dr. Jacob Raber, Ph.D., Behavioral Neuroscience, Effects of irradiation on cognition; role of Arc and apoE isoform

August 31, 2011, Discussion of Journal club: expectations, structure, best practices. Led by Dr. Jacoby

August 24, 2011, Ted, Does leptin act on serotonergic neurons to influence appetite

August 17, 2011, Branden, Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

August 10, 2011, Noah, RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Aug 3, 2011, presenter cancelled

July 27, 2011, Allison, TLR Signaling is Required for Salmonella Typhimurium Virulence

July 20, 2011, Katie, "Non-Apoptotic role of BID in inflammation and innate immunity,"

July 13, 2011, Danielle, "Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4"

July 6, 2011, Prof. Wayne Zundel, SOM-Radiation Oncology Department, Impact of the Von Hippel-Lindau Tumor Suppressor in Cancer & Ischemia-Related Pathologies

June 29, 2011, Yossi, Neurodegenerative Diseases Target Large-Scale Human Brain Networks,

June 22, 2011, Charlie, Cryptococcus gattii in the Pacific Northwest: Mechanisms of azole drug resistance

June 15, 2011, Dan, Ethics and Clinical Research

June 8, 2011, Greg, Presynaptic Facilitation by Neuropeptide Signaling Mediates Odor-Driven Food Search,

June 1, 2011, Prof. Michael Riscoe, Ph.D., Director, Experimental Chemotherapy Lab, Back to the future for discovery of new antimalarial drugs"

May 25, 2011, Garth, Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice"

May 18, 2011, QiLiang, Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress,

May 11, 2011, Andrew, Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension.

April 27, 2011, Josh. Cross-dressed dendritic cells drive memory CD8(+) T-cell activation after viral infection

April 20, 2011, Chris S. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle,

April 13, 2011, Rebecca R., Programming the magnitude and persistence of antibody responses with innate immunity,

April 6, 2011, Prof. David Huang, Center for Opthalmic Optics and Lasers, "Optical Coherence Tomography in Ophthalmology"

March 30, 2011, Jaime, Genetic Polymorphisms of the b2-Adrenergic Receptor Relate to Guanosine Protein-coupled Stimulator Receptor Dysfunction in Fibromyalgia Syndrome

March 16, 2011, Dominic, Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone

March 9, 2011, Derek, "PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release"

March 2, 2011, Prof. Dana Madison, Endocrinology, "The impact of PARP inhibitors on non-traditional PARP function and p21 activation"

Feb 23, 2011, Zach, "Effect of epithelial stem cell transplantation on noise-induced hearing loss in adult mice"

Feb 16, 2011, Chris B.,  Direct Conversion of Human Fibroblasts to Multilineage Blood Progenitors"

Feb 9, 2011, Art, "Histopathological Correlates of MRI-Defined Chronic Perinatal White Matter Injury" (in revision)

Feb 2, 2011, Prof W. Harvard Fleming, Medicine & Pediatrics, "Stem cells, Leukemia & the Microenvironment"

Jan 26, 2011, Emily, "Sulfonylurea Receptor 1 Mutations That Cause Opposite Insulin Secretion Defects with Chemical Chaperone Exposure"

Jan 12, 2011, Kimmy, "Clinical Assessment Incorporating a Personal Genome"

Jan 5, 2011, Prof. Alan Sandler, Hematology and Oncology,  "Progress in the Treatment of Advanced Non-Small Cell Lung Cancer...Seriously"

 Attendance at the MD/PhD Journal club is required for MD/PhD students except in extenuating circumstances, or conflicting scheduled rotations.