MD/PhD Journal Club
MD-PhD Journal Club presentations
Journal club is a mixture of Faculty Grand Rounds presentations and student presented journal clubs. Journal club is on Wednesdays at noon in the Medical Research Building. Guidelines for presentations are available here.
Below is a schedule of upcoming presentations, at the bottom is a list of past presentations. (Students are listed by first name only.) Where possible, articles are linked to their source.
May 22, Jenya, Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637164/
May 29, Johanna, Documentation Preparation
June 5, Yossi
June 12, Dominic
June 19, Andy
June 26, Allison
July 10, Derek
July 17, Julie
July 24, Zach
July 31, Jaime
August 7, Dr. Wassana Yantasee, Biomedical Engineering
August 14, Q
May 15, Greg, Novel airway imaging applied to neuroimmune interactions in asthma
May 8, Garth, New Thoughts on Old Blood Clots
May 1, Dr. James Tanyi, Radiation Medicine, A pilot study on the use of DCE-MRI in the prediction of head and neck cancer response to chemoradiation
April 24, Charlie, Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET http://www.nature.com/nm/journal/v18/n6/full/nm.2753.html
April 17, Devon, Identifying Personal Genomes by Surname Inference http://www.sciencemag.org/content/339/6117/321.full.pdf
April 10, Zip, Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice URL: http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2813%2900007-6
April 3, Dr.s Kristina Young M.D., Ph.D. and Sophia Bornstein M.D., Ph.D. Sophia: Tumor-Initiating Cell Microenvironment in Head and Neck Squamous Cell Carcinoma, Kristina: Targeted Alteration of the Tumor Immune Environment to Increase Chemoradiosensitivity in Rectal Cancer Together: transitioning from MD/PhD to residency and beyond
March 20, Cheryl MYC Suppresses Cancer Metastasis by Direct Transcriptional Silencing of αv and β3 Integrin Subunits http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366024/
March 13, Kevin, Diagnostic Inaccuracy of Smartphone Applications for Melanoma Detection http://archderm.jamanetwork.com/article.aspx?articleid=1557488
March 6, Cymon, Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes http://www.nature.com/mt/journal/v20/n9/full/mt2012107a.html
February 27, Katie L., Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c http://www.ncbi.nlm.nih.gov/pubmed/22521878
February 20, Anjali, The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells http://www.sciencedirect.com/science/article/pii/S107476131100505X
February 6 Dr Bob Hitzemann, Behavioral Neuroscience, Systems Biology, Gene Networks and Behavior
January 30, Rebecca W. Adult hippocampal neurogenesis buffers stress response and depressive behavior, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162077/
January 23, Dominic, A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid ? http://stm.sciencemag.org/content/4/147/147ra111.full.pdf
January 16, Noah, CCR5 is a receptor for Staphylococcus aureus leukotoxin ED http://www.nature.com/nature/journal/v493/n7430/full/nature11724.html
January 9, Dr. Landon King, Pulmonary & Critical Care Medicine, Vice Dean for Research, Johns Hopkins University, Acute Respiratory Distress Syndrome: Be It Hereby Resolved...
January 2, Dr. Lina Reiss, Otolaryngology, Pitch plasticity and binaural spectral integration with cochlear implants
December 19, Garth, Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796262/
December 12, Dr. Leslie Kahl, MD Curriculum Reform December 5, Dr. Mary Kelley, Casey Eye Institute Restoration of the Trabecular Meshwork by Stem Cells
November 28, Branden, Cells keep a memory of their tissue origin during axolotl limb regeneration http://www.nature.com/nature/journal/v460/n7251/full/nature08152.html
November 14, Danielle, Mechanistic implications for LDL receptor degredation from the PCSK9/LDLR structure at neutral pH http://www.nature.com/embor/journal/v12/n12/abs/embor2011205a.html
November 7, Dr. Hiroyuki Nakai, M.D., Ph.D., Molecular & Medical Genetics, AAV vectors in gene therapy
October 31, Yossi, Dopaminergic neurons inhibit striatal output through non-canonical release of GABAURL: http://www.nature.com/nature/journal/v490/n7419/full/nature11466.html
October 24, Zach, Photochemical Restoration of Visual Responses in Blind Mice, http://www.cell.com/neuron/abstract/S0896-6273(12)00488-6
October 17, QiLiang, Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stresshttp://ajpgi.physiology.org/content/302/2/G260.long
October 10, Zipei, PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain. http://www.cell.com/cancer-cell/abstract/S1535-6108%2809%2900078-6
October 3, Dr. Tom Scanlan, Physiology & Pharmacology, Discovery and Development of Sobetirome—a Selective Thyroid Hormone Analog
September 26, Andy, Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia http://www.jci.org/articles/view/17189
September 19, Devon, A Stem Cell-Based Approach to Cartilage Repair http://www.sciencemag.org/content/336/6082/717.full?sid=6eb43385-3edc-4a77-86ce-69a895b75077
September 12, Jaime, New insights into the role of VIP on the ratio of T-cell subsets during the development of autoimmune diabetes. http://www.nature.com/icb/journal/v88/n7/full/icb201029a.html
September 5, Dr. Megan Troxell, Translational Breast Pathology
August 29, Dr. David Jacoby, Welcome new students, introductions, journal club expectations and best practices
August 22, Derek, Leukemia-stimulated bone marrow endothelium promotes leukemia cell survival: http://www.sciencedirect.com/science/article/pii/S0301472X06000592
August 15, Charlie, Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs http://www.sciencedirect.com/science/article/pii/S1535610811003576
August 8, Kevin, Cell Lineage Analysis of the Mammalian Female Germline http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002477
August 1, Dr. Jon Purnell, Endocrinology, "Human Knockouts: Using rare disorders of fatty acid oxidation to explore the cause of insulin resistance."
July 25, Andy, Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. http://www.nature.com.liboff.ohsu.edu/nature/journal/v482/n7383/full/nature10814.html
July 18, Julie, Long-term use of a left ventricular assist device for end stage heart failure http://www.ncbi.nlm.nih.gov/pubmed/11794191
July 11, Allison, Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery http://stm.sciencemag.org/content/4/140/140ra88.full
June 20, Becky, The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain"
June 13, Ted, mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass http://www.cell.com/cell-metabolism/abstract/S1550-4131(11)00177-X
June 6, Dr. Terry Morgan, Pathology and OB/Gyn, Fetal programming of white coat hypertension in growth restricted mice
May 30, 2012 Garth, Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia, http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112304
May 23, 2012 Dominic, SKCa and IKCa Channels, Myogenic Tone, and Vasodilator Responses in Middle Cerebral Arteries and Parenchymal Arterioles, http://stroke.ahajournals.org/content/40/4/1451
May 16, 2012 Miz & Doran (with special guests), Reflections on the Residency Interview Road
May 9, Noah, Interactions between cancer stem cells and their niche govern metastatic colonization, http://www.nature.com/nature/journal/v481/n7379/full/nature10694.html
May 2, Dr. Robert O'Rourke, Surgery, Inflammation and Immunity in Obesity and Metabolic Disease
April 25, 2012 Derek, Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum, http://www.sciencemag.org/content/332/6030/687.full
April 18, 2012 Zach, Adolescent development of psychosis as an outcome of hearing impairment: a 10-year longitudinal study, http://journals.cambridge.org/action/displayFulltext?type=6&fid=8011212&jid=PSM&volumeId=41&issueId=03&aid=8011211&fulltextType=RA&fileId=S0033291710000978
April 11, 2012, Branden, Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection http://www.sciencemag.org/content/327/5962/198.full.html
April 4, 2012, Jon D. Hennebold, Ph.D. Div. of Reproductive Sciences, The Search for Non-Hormonal Female Contraceptives: A Molecular Approach
March 21, 2012, Devon, Regeneration and Orthotopic Transplantation of a Bioartificial Lung, http://www.nature.com/nm/journal/v16/n8/abs/nm.2193.html
March 14, 2012, Dr. Joe Gray, Department of Biomedical Engineering, Increasing the Precision With Which We Treat Breast Cancer
March 7, 2012, Charlie, Inflammation and proliferation act together to mediate intestinal cell fusion, http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006530
February 29, 2012, Zipei, "A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" http://www.nature.com/nature/journal/v481/n7382/full/nature10777.html
February 22, 2012, Danielle, In Vitro and In Vivo Studies Identify Important Features of Dengue Virus pr-E Protein Interactions http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1001157
February 15, 2012, Kevin, Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos" http://stke.sciencemag.org/cgi/content/full/sigtrans;2/66/ra16
February 8, 2012, QiLiang, Environmentally induced antinociception and hyperalgesia in rats and mice, http://www.sciencedirect.com/science/article/pii/S0006899311014272
February 1, 2012, Dr. Joshi Alumkal, Oncology, Advances in Prostate Cancer Treatment: Lessons Learned
January 25, 2012, Katie, A novel retinoblastoma therapy from genomic and epigenetic analyses" http://www.nature.com.liboff.ohsu.edu/nature/journal/v481/n7381/full/nature10733.html
January 11, 2012, Yossi Binaural auditory processing in multiple sclerosis subjects http://www.sciencedirect.com/science/article/pii/0378595593900659
January 4, 2012, Dr. Mary Stenzel-Poore, Ph.D. Molecular Microbiology & Immunology Unleashing the Brain's Endogenous Neuroprotective Strategies Through Toll-like Receptors
End of 2011
December 14, 2011, Allison, The ageing systemic milieu negatively regulates neurogenesis and cognitive function
December 7, 2011, Dr. Mary Heinricher, Behavioral Neuroscience, "How the Brain Controls Pain"
November 30, 2011, Greg, Superresolution Imaging of Chemical Synapses in the Brain" http://download.cell.com/neuron/pdf/PIIS0896627310009372.pdf?intermediate=true
November 16, 2011, Andy, K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension http://www.sciencemag.org/content/331/6018/768.full
November 9, 2011, Garth, "Tumor Self-Seeding by Circulating Cancer Cells" http://www.sciencedirect.com/science/article/pii/S0092867409014378 Also, an editorial summarizing the main findings: http://www.sciencedirect.com/science/article/pii/S0092867409015608
November 2, 2011, Dr. Michael Hutchens, Sex and Perioperative Acute Kidney Injury
October 26, 2011, Art two related articles: A Small-Molecule Smoothened Agonist Prevents Glucocorticoid-Induced Neonatal Cerebellar Injury http://stm.sciencemag.org.liboff.ohsu.edu/content/3/105/105ra104.full.pdf Preterm Cerebellar Growth Impairment After Postnatal Exposure to Glucocorticoids http://stm.sciencemag.org.liboff.ohsu.edu/content/3/105/105ra105.full.pdf
October 19, 2011, Rebecca W., Erroneous analyses of interactions in neuroscience: a problem of significance http://www.nature.com/neuro/journal/v14/n9/full/nn.2886.html
October 12, 2011, Derek, Regulation of the HIF-1a Level Is Essential for Hematopoietic Stem Cells" http://www.sciencedirect.com/science/article/pii/S1934590910003449
October 5, 2011, Dr. Debbie Lewinsohn, M.D. Pediatrics, Lessons learned from primary infection with M. tuberculosis
September 28, 2011, Jaime, A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories, http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2011293a.html
September 21, 2011, Zach, Vascular anastomosis using controlled phase transition in poloxamer gels, http://www.nature.com/nm/journal/v17/n9/nm.2424.html
September 14, 2011, Dominic, Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress
September 21, 2011, Zach, Vascular anastomosis using controlled phase transition in poloxamer gels, http://www.nature.com/nm/journal/v17/n9/nm.2424.html
September 14, 2011, Dominic, Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-? http://www.pnas.org/content/108/12/5063
September 7, 2011, Dr. Jacob Raber, Ph.D., Behavioral Neuroscience, Effects of irradiation on cognition; role of Arc and apoE isoform
August 31, 2011, Discussion of Journal club: expectations, structure, best practices. Led by Dr. Jacoby
August 24, 2011, Ted, Does leptin act on serotonergic neurons to influence appetite http://www.cell.com/cell-metabolism/abstract/S1550-4131(11)00140-9 http://www.cell.com/abstract/S0092-8674(09)00907-6
August 17, 2011, Branden, Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine http://www.nature.com/ng/journal/v43/n1/abs/ng.722.html
August 10, 2011, Noah, RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiahttp://www.nature.com/nature/journal/vaop/ncurrent/full/nature10334.html
Aug 3, 2011, presenter cancelled
July 27, 2011, Allison, TLR Signaling is Required for Salmonella Typhimurium Virulence http://www.sciencedirect.com/science/article/pii/S0092867411000705
July 20, 2011, Katie, "Non-Apoptotic role of BID in inflammation and innate immunity," http://www.nature.com/nature/journal/v474/n7349/full/nature09982.html
July 13, 2011, Danielle, "Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4" http://www.sciencemag.org/content/332/6029/600
July 6, 2011, Prof. Wayne Zundel, SOM-Radiation Oncology Department, Impact of the Von Hippel-Lindau Tumor Suppressor in Cancer & Ischemia-Related Pathologies
June 29, 2011, Yossi, Neurodegenerative Diseases Target Large-Scale Human Brain Networks, http://www.sciencedirect.com/science/article/pii/S0896627309002499
June 22, 2011, Charlie, Cryptococcus gattii in the Pacific Northwest: Mechanisms of azole drug resistance
June 15, 2011, Dan, Ethics and Clinical Research
June 8, 2011, Greg, Presynaptic Facilitation by Neuropeptide Signaling Mediates Odor-Driven Food Search, http://www.sciencedirect.com/science/article/pii/S009286741100122X
June 1, 2011, Prof. Michael Riscoe, Ph.D., Director, Experimental Chemotherapy Lab, Back to the future for discovery of new antimalarial drugs"
May 25, 2011, Garth, Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice"
May 18, 2011, QiLiang, Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress, http://www.nature.com/mp/journal/v15/n12/full/mp201034a.html
May 11, 2011, Andrew, Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension. http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.2337.html
April 27, 2011, Josh. Cross-dressed dendritic cells drive memory CD8(+) T-cell activation after viral infection http://www.nature.com/nature/journal/v471/n7340/full/nature09863.html
April 20, 2011, Chris S. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle, http://linkinghub.elsevier.com/retrieve/pii/S0888-7543(10)00196-5
April 13, 2011, Rebecca R., Programming the magnitude and persistence of antibody responses with innate immunity, http://www.nature.com/nature/journal/v470/n7335/full/nature09737.html
April 6, 2011, Prof. David Huang, Center for Opthalmic Optics and Lasers, "Optical Coherence Tomography in Ophthalmology"
March 9, 2011, Derek, "PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release"
March 2, 2011, Prof. Dana Madison, Endocrinology, "The impact of PARP inhibitors on non-traditional PARP function and p21 activation"
Feb 16, 2011, Chris B., Direct Conversion of Human Fibroblasts to Multilineage Blood Progenitors"
Feb 9, 2011, Art, "Histopathological Correlates of MRI-Defined Chronic Perinatal White Matter Injury" (in revision)
Feb 2, 2011, Prof W. Harvard Fleming, Medicine & Pediatrics, "Stem cells, Leukemia & the Microenvironment"
Jan 12, 2011, Kimmy, "Clinical Assessment Incorporating a Personal Genome"
Jan 5, 2011, Prof. Alan Sandler, Hematology and Oncology, "Progress in the Treatment of Advanced Non-Small Cell Lung Cancer...Seriously"
Attendance at the MD/PhD Journal club is required for MD/PhD students except in extenuating circumstances, or conflicting scheduled rotations.