OHSU

MD/PhD Journal Club

MD-PhD Journal Club presentations

Journal club is a mixture of Faculty Grand Rounds presentations and student presented journal clubs. Journal club is on Wednesdays at noon in the Medical Research Building. Guidelines for presentations are available here.

Below is a schedule of upcoming presentations, at the bottom is a list of past presentations. (Students are listed by first name only.) Where possible, articles are linked to their source.

May 23, Dominic, SKCa and IKCa Channels, Myogenic Tone, and Vasodilator Responses in Middle Cerebral Arteries and Parenchymal Arterioles, http://stroke.ahajournals.org/content/40/4/1451

May 30, Garth, Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia, http://www.nejm.org/doi/pdf/10.1056/NEJMoa1112304

June 6, Dr. Terry Morgan, Pathology and OB/Gyn, Fetal programming of white coat hypertension in growth restricted mice

June 13, Ted

June 20, Becky

June 27, cancelled

July 4, cancelled

July 11, Allison

July 18, Julie

July 25, Andrew

August 1, Dr. Jon Purnell, Endocrinology

August 8, Jaime

August 29, Dr. David Jacoby,  Welcome new students, introductions, journal club expectations and best practices
 

 

Completed Presentations

May 16, Miz & Doran (with special guests), Reflections on the Residency Interview Road

May 9, Noah, Interactions between cancer stem cells and their niche govern metastatic colonization, http://www.nature.com/nature/journal/v481/n7379/full/nature10694.html

May 2, Dr. Robert O'Rourke, Surgery,  Inflammation and Immunity in Obesity and Metabolic Disease

April 25, 2012 Derek,  Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum, http://www.sciencemag.org/content/332/6030/687.full

April 18, 2012 Zach, Adolescent development of psychosis as an outcome of hearing impairment: a 10-year longitudinal study, http://journals.cambridge.org/action/displayFulltext?type=6&fid=8011212&jid=PSM&volumeId=41&issueId=03&aid=8011211&fulltextType=RA&fileId=S0033291710000978

April 11, 2012, Branden, Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection http://www.sciencemag.org/content/327/5962/198.full.html

April 4, 2012, Jon D. Hennebold, Ph.D. Div. of Reproductive Sciences, The Search for Non-Hormonal Female Contraceptives: A Molecular Approach

March 21, 2012, Devon, Regeneration and Orthotopic Transplantation of a Bioartificial Lung, http://www.nature.com/nm/journal/v16/n8/abs/nm.2193.html

March 14, 2012, Dr. Joe Gray, Department of Biomedical Engineering, Increasing the Precision With Which We Treat  Breast Cancer

March 7, 2012, Charlie, Inflammation and proliferation act together to mediate intestinal cell fusion, http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006530

February 29, 2012, Zipei,  "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" http://www.nature.com/nature/journal/v481/n7382/full/nature10777.html

February 22, 2012, Danielle, In Vitro and In Vivo Studies Identify Important Features of Dengue Virus pr-E Protein Interactions  http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1001157

February 15, 2012, Kevin,  Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos"  http://stke.sciencemag.org/cgi/content/full/sigtrans;2/66/ra16

February 8, 2012, QiLiang, Environmentally induced antinociception and hyperalgesia in rats and mice, http://www.sciencedirect.com/science/article/pii/S0006899311014272

February 1, 2012,  Dr. Joshi Alumkal, Oncology, Advances in Prostate Cancer Treatment: Lessons Learned

January 25, 2012, Katie, A novel retinoblastoma therapy from genomic and epigenetic analyseshttp://www.nature.com.liboff.ohsu.edu/nature/journal/v481/n7381/full/nature10733.html

January 18, 2012, Dan, Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children

January 11, 2012, Yossi Binaural auditory processing in multiple sclerosis subjects http://www.sciencedirect.com/science/article/pii/0378595593900659

January 4, 2012, Dr. Mary Stenzel-Poore, Ph.D. Molecular Microbiology & Immunology Unleashing the Brain's Endogenous Neuroprotective Strategies Through Toll-like Receptors

End of 2011

December 14, 2011, Allison, The ageing systemic milieu negatively regulates neurogenesis and cognitive function

December 7, 2011, Dr. Mary Heinricher, Behavioral Neuroscience, "How the Brain Controls Pain"

November 30, 2011, Greg, Superresolution Imaging of Chemical Synapses in the Brain" http://download.cell.com/neuron/pdf/PIIS0896627310009372.pdf?intermediate=true

November 16, 2011, Andy, K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension  http://www.sciencemag.org/content/331/6018/768.full

November 9, 2011, Garth, "Tumor Self-Seeding by Circulating Cancer Cells" http://www.sciencedirect.com/science/article/pii/S0092867409014378  Also, an editorial summarizing the main findings: http://www.sciencedirect.com/science/article/pii/S0092867409015608

November 2, 2011, Dr. Michael Hutchens, Sex and Perioperative Acute Kidney Injury

October 26, 2011, Art two related articles: A Small-Molecule Smoothened Agonist Prevents Glucocorticoid-Induced Neonatal Cerebellar Injury http://stm.sciencemag.org.liboff.ohsu.edu/content/3/105/105ra104.full.pdf  Preterm Cerebellar Growth Impairment After Postnatal Exposure to Glucocorticoids http://stm.sciencemag.org.liboff.ohsu.edu/content/3/105/105ra105.full.pdf

October 19, 2011, Rebecca W.,  Erroneous analyses of interactions in neuroscience: a problem of significance  http://www.nature.com/neuro/journal/v14/n9/full/nn.2886.html

October 12, 2011, Derek, Regulation of the HIF-1a Level Is Essential for Hematopoietic Stem Cells"  http://www.sciencedirect.com/science/article/pii/S1934590910003449

October 5, 2011, Dr. Debbie Lewinsohn, M.D. Pediatrics, Lessons learned from primary infection with M. tuberculosis

September 28, 2011, Jaime, A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories, http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2011293a.html

September 21, 2011, Zach, Vascular anastomosis using controlled phase transition in poloxamer gels, http://www.nature.com/nm/journal/v17/n9/nm.2424.html

September 14, 2011, Dominic, Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress

September 21, 2011, Zach, Vascular anastomosis using controlled phase transition in poloxamer gels, http://www.nature.com/nm/journal/v17/n9/nm.2424.html

September 14, 2011, Dominic, Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β http://www.pnas.org/content/108/12/5063

September 7, 2011, Dr. Jacob Raber, Ph.D., Behavioral Neuroscience, Effects of irradiation on cognition; role of Arc and apoE isoform

August 31, 2011, Discussion of Journal club: expectations, structure, best practices. Led by Dr. Jacoby

August 24, 2011, Ted, Does leptin act on serotonergic neurons to influence appetite http://www.cell.com/cell-metabolism/abstract/S1550-4131(11)00140-9 http://www.cell.com/abstract/S0092-8674(09)00907-6

August 17, 2011, Branden, Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine  http://www.nature.com/ng/journal/v43/n1/abs/ng.722.html

August 10, 2011, Noah, RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiahttp://www.nature.com/nature/journal/vaop/ncurrent/full/nature10334.html

Aug 3, 2011, presenter cancelled

July 27, 2011, Allison, TLR Signaling is Required for Salmonella Typhimurium Virulence http://www.sciencedirect.com/science/article/pii/S0092867411000705

July 20, 2011, Katie, "Non-Apoptotic role of BID in inflammation and innate immunity," http://www.nature.com/nature/journal/v474/n7349/full/nature09982.html

July 13, 2011, Danielle, "Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4" http://www.sciencemag.org/content/332/6029/600  

July 6, 2011, Prof. Wayne Zundel, SOM-Radiation Oncology Department, Impact of the Von Hippel-Lindau Tumor Suppressor in Cancer & Ischemia-Related Pathologies

June 29, 2011, Yossi, Neurodegenerative Diseases Target Large-Scale Human Brain Networks, http://www.sciencedirect.com/science/article/pii/S0896627309002499

June 22, 2011, Charlie, Cryptococcus gattii in the Pacific Northwest: Mechanisms of azole drug resistance

June 15, 2011, Dan, Ethics and Clinical Research

June 8, 2011, Greg, Presynaptic Facilitation by Neuropeptide Signaling Mediates Odor-Driven Food Search,  http://www.sciencedirect.com/science/article/pii/S009286741100122X

June 1, 2011, Prof. Michael Riscoe, Ph.D., Director, Experimental Chemotherapy Lab, Back to the future for discovery of new antimalarial drugs"

May 25, 2011, Garth, Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice"
http://bloodjournal.hematologylibrary.org/content/116/5/806.full.pdf+html

May 18, 2011, QiLiang, Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress, http://www.nature.com/mp/journal/v15/n12/full/mp201034a.html

May 11, 2011, Andrew, Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension. http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.2337.html

April 27, 2011, Josh. Cross-dressed dendritic cells drive memory CD8(+) T-cell activation after viral infection http://www.nature.com/nature/journal/v471/n7340/full/nature09863.html

April 20, 2011, Chris S. Conserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscle, http://linkinghub.elsevier.com/retrieve/pii/S0888-7543(10)00196-5

April 13, 2011, Rebecca R., Programming the magnitude and persistence of antibody responses with innate immunity, http://www.nature.com/nature/journal/v470/n7335/full/nature09737.html

April 6, 2011, Prof. David Huang, Center for Opthalmic Optics and Lasers, "Optical Coherence Tomography in Ophthalmology"

March 30, 2011, Jaime, Genetic Polymorphisms of the b2-Adrenergic Receptor Relate to Guanosine Protein-coupled Stimulator Receptor Dysfunction in Fibromyalgia Syndrome

March 16, 2011, Dominic, Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone

March 9, 2011, Derek, "PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release"

March 2, 2011, Prof. Dana Madison, Endocrinology, "The impact of PARP inhibitors on non-traditional PARP function and p21 activation"

Feb 23, 2011, Zach, "Effect of epithelial stem cell transplantation on noise-induced hearing loss in adult mice"

Feb 16, 2011, Chris B.,  Direct Conversion of Human Fibroblasts to Multilineage Blood Progenitors

Feb 9, 2011, Art, "Histopathological Correlates of MRI-Defined Chronic Perinatal White Matter Injury" (in revision)

Feb 2, 2011, Prof W. Harvard Fleming, Medicine & Pediatrics, "Stem cells, Leukemia & the Microenvironment"

Jan 26, 2011, Emily, "Sulfonylurea Receptor 1 Mutations That Cause Opposite Insulin Secretion Defects with Chemical Chaperone Exposure"

Jan 12, 2011, Kimmy, "Clinical Assessment Incorporating a Personal Genome"

Jan 5, 2011, Prof. Alan Sandler, Hematology and Oncology,  "Progress in the Treatment of Advanced Non-Small Cell Lung Cancer...Seriously"

 Attendance at the MD/PhD Journal club is required for MD/PhD students except in extenuating circumstances, or conflicting scheduled rotations.