OHSU

Graduate Studies Faculty

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David L. Farrens, Ph.D.

Associate Professor
Admin Unit: SOM-Biochemistry & Molecular Biology Department
Phone: 503-494-0583
Lab Phone: 503-494-0583
Fax: 503-494-8393
Office: MRB 504
Mail Code: L224
Programs:
Biochemistry & Molecular Biology
Program in Molecular & Cellular Biosciences
Research Interests:
-Structural and functional studies of G-protein coupled receptors (GPCRs)and affiliated proteins. -Determining common structural mechanisms involved in GPCR activation and attenuation. -Visual and signal transduction and disease. -Cannabninoid receptor signalling. -Development and use of novel physical and biochemical techniques -Structural and Dynamic studies using site-directed spectroscopy (fluorescence and EPR). » PubMed Listing
Preceptor Rotations
Dr. Farrens has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Farrens has not indicated availability as a mentor at this time.
Profile
  

1980-1985    University of Nebraska-Lincoln    B.Sc.   Chemistry (Biology minor)
1985-1991    University of Nebraska-Lincoln    Ph.D.    Chemistry
1991               RIKEN Institute, Tokyo, Japan                                       
1992-1996     Massachusetts Institute of Technology                             
1996               Jules-Stein Eye Institute, UCLA                                      
1996-2005     OHSU     Assistant Professor, Biochemistry and Molecular Biology
2005-              OHSU    Associate Professor, Biochemistry and Molecular Biology

Current Graduate Students:  Abhinav Sinha (joined lab 2005) and  Jonathan Fay (joined lab 2006).

Past Graduate Students:
Dr. Jay Janz (2004), Dr. Martha Sommer (2006), Dr. Steven Mansoor (2007).
 

Select Publications (from past 5 years):

Tsukamoto, Hisao, Farrens, D.L., Koyanagi, M. and Terakita, A. (2009) “The magnitude of the light-induced conformational change in different rhodopsins correlates with their ability to activate G proteins” J. Biol. Chem. 284(31):20676-83.

Sommer, ME, Farrens, DL, McDowell, JH, Weber, LA, and Smith, WC (2007) "Dynamics of Arrestin-Rhodopsin Interactions: Loop Movement is Involved in Arrestin Activation and Receptor Binding." J. Biol. Chem. 282, 25560-8.

DeWitt, M.A., Kliegman, J.A., Helmann, J.D., Brennan, R.G., Farrens, D.L. and Glasfeld. A. (2007) “The Conformations of the Manganese Transport Regulator of Bacillus subtilis in its Metal-free State” J. Mol. Biol. 365, 1257–1265

Sommer, M.E. and Farrens, D.L. (2006) “Arrestin Can Act as a Regulator of Rhodopsin Photochemistry” Vision Research 46: 4532-4546.

Yao, X., Parnot, C., Deupi, X., Ratinalla, P., Swaminath, G., Farrens, D. , Kobilka, B. (2006) “Coupling ligand structure to specific conformational switches in the β2 adrenoceptor “ Nature Chemical Biology 2: 417-422.

Sommer, M.E., Smith, W.C. and Farrens, D.L. (2006) "Dynamics of Arrestin-Rhodopsin Interactions: Acidic Phospholipids Enable binding of Arrestin to Purified Rhodopsin in Detergent” J. Biol. Chem. 281:9407-9417.

Mansoor, S.E., Palczewski, K. and Farrens, D.L. (2006) “Rhodopsin Self-Associates in Asolectin Liposomes” Proc. Natl. Acad. Sci. U.S.A 103:3060-3065.

Fay, J.F., Dunham, T.D. and Farrens, D.L. (2005) “Role of Cysteine Residues in the Human Cannabinoid Receptor (CB1): C264 and C257 are required for a Functional Receptor and Steric Bulk at C386 Impairs Antagonist SR141716A Binding” Biochemistry 44: 8757-8769.

Sommer, M.E., Smith, W.C. and Farrens, D.L. (2005) "Dynamics of arrestin-Rhodopsin interactions: Arrestin and retinal release are directly linked events" J. Biol. Chem. 280:6861-6871.

Mansoor, S.E. and Farrens, D.L. (2004) “High-Throughput Protein Structural Analysis Using Site-Directed Fluorescence Labeling and the Bimane Derivative (2-Pyridyl)dithiobimane” Biochemistry 43, 9426-9438.

Janz, J.M. and Farrens, D.L. (2004b) “Role of Retinal Hydrogen Bond Network in Rhodopsin Schiff Base Stability and Hydrolysis” J. Biol. Chem. 279:55886-55894.

Janz, J.M. and Farrens, D.L. (2004a) “Rhodopsin Activation Exposes a Key Hydrophobic Binding site for the Transducin α-Subunit C Terminus” J. Biol. Chem., 279: 29767 – 29773.