Graduate Studies Faculty
Evan F. Lind, Ph.D.
Programs:Cell & Developmental Biology
Molecular Microbiology & Immunology
Program in Molecular & Cellular Biosciences
Research Interests:AML, Leukemia, Hematopoietic Stem Cells, Infection, Autoimmunity, T Cells, Cancer AML, Leukemia, Hematopoietic Stem Cells, Infection, Immunology, Cancer, T cells, Dendritic Cells, Inflammation
Preceptor RotationsAcademic Term Available Fall 2016 Yes Spring 2016 Yes Summer 2017 Yes Fall 2017 Yes Winter 2017 Yes Spring 2017 Yes Winter 2018 Yes Summer 2018 Yes Fall 2018 Yes
Faculty MentorshipDr. Lind is available as a mentor for 2016-2017. Dr. Lind is available as a mentor for 2017-2018.
The goal of my research is to study the impact of hematological malignancies on immune function, with a focus on acute myeloid leukemia (AML). We are currently investigating immune defects associated with AML in the blood and bone marrow of patients both phenotypically and functionally. We use mass-spec based flow cytometry (CyTOF) to analyze the phenotype of immune cells in AML patients in fine resolution (35+ parameters). Further, we use mouse models with mutations in genes identified to play a role in human myelodysplastic syndromes and leukemia (TET2, Flt3, Jak2 and others) to study how leukemia evades immune detection. Another interest of the lab is to understand how microRNA (miRNA) expression controls dendritic cell maturation and function. We use gene deletion mouse models to study the impact of specific miRNA loss on DC ability to prime T cells and how that translates to antiviral immune responses. In the future this may allow for immune-based vaccine and other therapeutic interventions for leukemia.