Graduate Studies Faculty

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Matthew P. Butler, PhD

Assistant Professor, Oregon Institute of Occupational Health Sciences
Admin Unit: Oregon Institute of Occupational Health Sciences
Office: RJH 1586
Behavioral Neuroscience
Research Interests:
sleep research, circadian systems, melatonin » Click here for more about Dr. Butler's research » PubMed Listing
Preceptor Rotations
Dr. Butler has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Butler has not indicated availability as a mentor at this time.


I have a broad interest in how biological clocks are synchronized in organisms, and how these affect physiology and behavior. I have a particular interest in how shift work increases the risk for disease. Current efforts employ behavioral and physiological approaches in order to investigate the following:

1)    The effects of clock synchrony on cardiometabolic health.
2)    How the circadian clock governs sleep apnea severity in humans.
3)    Temporal patterns of sleep apnea as predictors of mortality.
4)    How the time of day of a traumatic brain injury changes its severity and prognosis.


Society for Research on Biological Rhythms
American Association of Sleep Medicine
Society for Neuroscience
Society for Behavioral Neuroendocrinology


2007 Ph.D. U.C. Berkeley, Dept. of Integrative Biology. Mentor: Irv Zucker, Ph.D.
1999 A.B. Princeton University, Dept. of Ecology and Evolutionary Biology


1. Pittman-Polletta B, Scheer FAJL, Butler MP, Shea SA, Hu K. 2013. The role of the circadian system in fractal neurophysiological control. Biological Reviews 88: 873-894, 2013. PMCID: PMC3766492.
2. Butler MP, Rainbow MN, Rodriguez E, Lyon SM, Silver R. 2012. Twelve hour days in the brain and behavior of split hamsters. European Journal of Neuroscience. 36: 2556-66. PMC in progress: NIHMS560770.
3. Butler MP, Karatsoreos IN, LeSauter J, Silver R. 2012. Dose-dependent effects of androgens on the circadian timing system and its response to light. Endocrinology. 153: 2344-2352. PMCID: PMC3339642.
4. Butler MP, Silver R.  2011. Divergent photic thresholds in the non-image forming visual system: entrainment, masking, and pupillary light reflex. Proceedings of the Royal Society B: Biological Sciences. 278: 745-750. PMCID: PMC3030845.
5. Butler MP, Turner KW, Park JH, Schoomer EE, Zucker I, Gorman MR. 2010.  Seasonal regulation of reproduction: altered role of melatonin under naturalistic conditions in hamsters.  Proceedings of the Royal Society B: Biological Sciences. 277: 2867-74. PMCID: PMC2981982.
6. Butler MP, Silver R.  2009.  Basis of robustness and resilience in the suprachiasmatic nucleus: Individual neurons form nodes in circuits that cycle daily.  Journal of Biological Rhythms 24: 340-352. PMCID: PMC3104278.
7. Butler MP, Trumbull JJ, Turner KW, Zucker I.  2007.  Timing of puberty and synchronization of seasonal rhythms by simulated natural photoperiods in female Siberian hamsters.  American Journal of Physiology 293: R413-R420.