OHSU

Graduate Studies Faculty

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Jeffrey W. Tyner, Ph.D.

Assistant Professor
Admin Unit: The Knight Cancer Institute
Phone: 503-346-0603
Lab Phone: 503-494-9188
Fax: 503-494-3688
Office: BRB 511
Mail Code: L592
Programs:
Cell & Developmental Biology
Program in Molecular & Cellular Biosciences
Cancer Biology
Research Interests:
Hematology/Oncology Kinase Signaling Genetics of Kinase Dysregulation Targeted Therapies Personalized Medicine » Click here for more about Dr. Tyner's research » PubMed Listing
Preceptor Rotations
Dr. Tyner has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Tyner might be available as a mentor for 2013-2014. Dr. Tyner might be available as a mentor for 2014-2015.
Profile

My research can be characterized by two primary interests: 1) identification of the genetic lesions underlying cancer pathogenesis for each cancer patient, and 2) identification of specific, gene-targeted therapies that can be individually tailored to cancer patients on the basis of their causative oncogenic lesions. Towards this end, I have developed two functional screening strategies making use of siRNA and small-molecule kinase inhibitor libraries to interrogate the genes and signaling pathways required for growth and viability of malignant cells. I have applied these techniques directly to primary cells from cancer patients to identify new oncogenes. It has also become clear that functional screening can only reveal part of the answer when used as a stand-alone technique. As such, I am integrating analysis of these same patient samples with a series of genomic techniques for the identification of point mutations, translocations, mis-splicing, or gene over-expression events. Simultaneous application of both functional and genomic screens will accelerate our understanding of the genes and pathways that contribute to neoplasia, such that cancer therapy can be individually tailored for each patient.