OHSU

Graduate Studies Faculty

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Julie Saugstad, Ph.D.

Associate Professor
Director, Core Molecular Laboratories & Training for Research,
Admin Unit: SOM-Anesthesiology and Peri-Operative Medicine Department
Phone: 503-494-4926
Lab Phone: 503-494-9061
Fax: 503-494-6482
Office: Hatfield Research Center, Room 558
Mail Code: HRC5N
Programs:
Molecular & Medical Genetics
Neuroscience Graduate Program
Program in Molecular & Cellular Biosciences
Research Interests:
Cerebral Ischemia, Neuroprotection, Alzheimer’s Disease » PubMed Listing
Preceptor Rotations
Academic Term Available Winter 2014 Maybe
Faculty Mentorship
Dr. Saugstad has not indicated availability as a mentor at this time.
Profile

My research is focused on elucidating the molecular and cellular mechanisms of signal transduction in brain injury and neurodegeneration. We are  focused on the role of microRNAs as effectors of post-transcriptional regulators of gene expression in response to ischemia and neuroprotection, as well as for their clinical utility as biomarkers for Alzheimer's Disease in human cerebrospinal fluid. My lab uses several molecular and biochemical techniques, including proteomics, microarrays, real-time quantitative PCR, immunocytochemistry, immunoblots, RNA blots, in situ hybridization, RNAi, and enzymatic assays.

Recent Publications

Lusardi T, Farr CD, Faulkner CL, Pignataro G, Yang T, Lan JQ, Simon RP, Saugstad JA* (2010) Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex, Journal of Cerebral Blood Flow and Metabolism, 30(4):744-56, Epub 2009 Dec 16, PMID: 20010955, NIHMSID168715 (Selected among “Top 4 finest scientific contributions to JCBFM by Dr. Ulrich Dirnagl and Dr. Martin Lauritzen from 2009 to 2010)

Staples M, Piper C, Yang T, Li M, Stowell C, Xiong ZG, Saugstad JA, Simon RP, Geromanos S, Langridge J, Lan JQ, Stenzel-Poore M, Zhou A (2010) Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance, Science Signaling 3(111):ra15, PMID: 20197544, NIHMSID216395

Saugstad JA* (2010) MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration (invited review), Journal of Cerebral Blood Flow and Metabolism 30(9):1564-1576, Epub 2010 July 7, PMID: 20606686, NIHMSID228517

Ceman S, Saugstad JA* (2011) MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease, Pharmacology & Therapeutics, 130(1):26-37, Epub 2011 Jan 20, PMID: 21256154

Jimenez-Mateos EM, Bray I, Sanz-Rodriguez A, Engel T, McKiernan RC, Mouri G, Tanaka K, Sano T, Saugstad JA, Simon RP, Stallings RL, and Henshall DC (2011) MiRNA expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132, American Journal of Pathology, 179(5):2519-2532,Epub 2011 Sep 23, PMID: 21945804

Lusardi TA, Thompson SJ, MacDonald IC, Lan J-Q, Theofilas P, Saugstad JA* (2012) Effect of (S)-3,5-DHPG on MicroRNA Expression in Mouse Brain, Experimental Neurology, 235(2):397-638, Epub 2012 January 28, PMID:22309833

Saugstad JA* (2013) MicroRNAs as effectors of brain function, Stroke, 44(6 Suppl 1):S17-9. doi: 10.1161/STROKEAHA.113.000985, PMID:23709715

Lusardi TA, Murphy SJ, Phillips JI, Chen YX, Davis CM, Young JM, Thompson SJ, Saugstad JA* (2014) MicroRNA responses to focal cerebral ischemia in male and female mouse brain, Frontiers in Molecular Neuroscience, 7(11):1-9, PMID:24574964, doi: 10.3389/fnmol.2014.00011

Murphy SJ, Lusardi TA, Phillips JI, Saugstad JA* (2014) Sex Differences in MicroRNA Expression During Development in Rat Cortex, Neurochemistry International, June 24. pii: S0197-0186(14)00146-6. doi: 10.1016/j.neuint.2014.06.007, PMID:24969725

EDUCATION

BS, 1981, Oklahoma State University

PhD, 1991, University of Oklahoma Health Science Center

Postdoctoral Fellow, 1991, Vollum Institute, OHSU

PREVIOUS POSITIONS

1996-2000            Research Assistant Professor, Pharmacology, Emory University, Atlanta, GA
2000-2012            Scientist, RS Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR
2012-present        Associate Professor, Anesthesiology & Perioperative Medicine, OHSU, Portland, OR

NON-ACADEMIC ACTIVITIES