OHSU

Graduate Studies Faculty

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Julie Saugstad, Ph.D.

Associate Professor
Director, Core Molecular Laboratories & Training for Research,
Admin Unit: SOM-Anesthesiology and Peri-Operative Medicine Department
Phone: 503-494-4926
Lab Phone: 503-494-9061
Fax: 503-494-6482
Office: Hatfield Research Center, Room 558
Mail Code: HRC5N
Programs:
Molecular & Medical Genetics
Neuroscience Graduate Program
Program in Molecular & Cellular Biosciences
Research Interests:
Cerebral Ischemia, Neuroprotection, Hydrocephalus, Alzheimer’s Disease » PubMed Listing
Preceptor Rotations
Dr. Saugstad has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Saugstad has not indicated availability as a mentor at this time.
Profile

My research is focused on elucidating the molecular and cellular mechanisms of signal transduction in neurodegenerative diseases and neurological disorders. To that end, we are currently focused on the role of microRNAs as effectors of post-transcriptional regulators of gene expression in response to ischemia and neuroprotection, as well as for signaling pathways mediated by the metabotropic glutamate receptors. We use a variety of molecular and biochemical techniques, including proteomics, microarrays, quantitative PCR, immunocytochemistry, immunoblots, RNA blots, in situ hybridization, RNAi, and enzymatic assays.

Recent Publications

Farr CD, Gafken PR, Norbeck AD, Doneanu CE, Stapels MD, Barofsky DF, Minami M, Saugstad JA*(2004) Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents, Journal of Neurochemistry 91, 438-450, PMID: 15447677, NIHMSID128760

Chu XP, Zhu XM, Close N, Wemmie JA, Price MP, Saugstad JA, Simon RP, Welsh MJ, Xiong ZG (2004) Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels, Journal of Neuroscience 24, 8678-8689, PMID: 15470133, NIHMSID228528

Saugstad JA*, Roberts J, Dong J, Zeitouni S, Evans RJ (2004) Analysis of the membrane topology of the acid-sensing ion channel 2a, Journal of Biological Chemistry 279:55514-55519, PMID: 15504740, NIHMSID228519

Alagarsamy S, Saugstad JA, Gereau IV RW, Mansuy I, Warren L, Conn PJ (2005) NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin, Neuropharmacology 49 Supplement 1:135-145, PMID: 16005030, NIHMSID228524

Grey F, McShea A, Allen E, Saugstad J, Carrington J, Nelson J (2005) Identification and characterization of human cytomegalovirus-encoded microRNAs, Journal of Virology 79:12095-12099, PMID: 16140786

Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA, Simon RP (2006) Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons, Journal of Biological Chemistry 281:7429-7436, PMID: 16431916, NIHMSID7941

Chu XP, Close N, Saugstad JA, Xiong ZG (2006) ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents, Journal of Neuroscience 26:5329-5339, PMID: 16707785, NIHMSID228525

Chai S, Li M, Lan JQ, Xiong ZG, Saugstad JA, Simon RP (2007) A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a, Journal of Biological Chemistry, 282:22668-22677, PMID: 17548344, NIHMSID228522

Saugstad JA*, Ingram SL (2007) Group I Metabotropic Glutamate Receptors. In The Glutamate Receptors, (Eds. Gereau IV, RW and Swanson, GT) Humana Press, pp. 387-463

Meller R, Thompson SJ, Lusardi TA, Ordonez AN, Ashley MD, Wang W, Torrey DJ, Henshall DC, Gafken PR, Saugstad JA, Xiong ZG, Simon RP (2008) Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance, Journal of Neuroscience 28:50-59, PMID: 18171922, NIHMSID124499

Lusardi T, Farr CD, Faulkner CL, Pignataro G, Yang T, Lan JQ, Simon RP, Saugstad JA*(2010) Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex, Journal of Cerebral Blood Flow and Metabolism, 30(4):744-56, Epub 2009 Dec 16, PMID: 20010955, NIHMSID168715 (Selected among “Top 4 finest scientific contributions to JCBFM by Dr. Ulrich Dirnagl and Dr. Martin Lauritzen from 2009 to 2010)

Staples M, Piper C, Yang T, Li M, Stowell C, Xiong ZG, Saugstad JA, Simon RP, Geromanos S, Langridge J, Lan JQ, Stenzel-Poore M, Zhou A (2010) Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance, Science Signaling 3(111):ra15, PMID: 20197544, NIHMSID216395

Saugstad JA*(2010) MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration (invited review), Journal of Cerebral Blood Flow and Metabolism 30(9):1564-1576, Epub 2010 July 7, PMID: 20606686, NIHMSID228517

Ceman S, Saugstad JA* (2011) MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease, Pharmacology & Therapeutics, 130(1):26-37, Epub 2011 Jan 20, PMID: 21256154

Jimenez-Mateos EM, Bray I, Sanz-Rodriguez A, Engel T, McKiernan RC, Mouri G, Tanaka K, Sano T, Saugstad JA, Simon RP, Stallings RL, and Henshall DC (2011) MiRNA expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132, American Journal of Pathology, 179(5):2519-2532,Epub 2011 Sep 23, PMID: 21945804

Lusardi TA, Thompson SJ, MacDonald IC, Lan J-Q, Theofilas P, Saugstad JA* (2012) Effect of (S)-3,5-DHPG on MicroRNA Expression in Mouse Brain, Experimental Neurology, 235(2):397-638, Epub 2012 January 28, PMID:22309833

EDUCATION

BS, 1981, Oklahoma State University

PhD, 1991, University of Oklahoma Health Science Center

Postdoctoral Fellow, 1991, Vollum Institute, OHSU

PREVIOUS POSITIONS

1996-2000            Research Assistant Professor, Pharmacology, Emory University, Atlanta, GA
2000-2012            Scientist, RS Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR
2012-present        Associate Professor, Anesthesiology & Perioperative Medicine, OHSU, Portland, OR

NON-ACADEMIC ACTIVITIES

Spending time with family (human & furry), gardening, redecorating, reading, and cooking