Graduate Studies Faculty
Joshi J. Alumkal, M.D.
Programs:Molecular & Medical Genetics
Research Interests:Prostate cancer, epigenetics, treatment resistance, LSD1, AR
Preceptor RotationsDr. Alumkal has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Alumkal has not indicated availability as a mentor at this time.
Our laboratory focuses on identifying mechanisms by which prostate cancer progresses to the lethal form of the disease. We believe molecular methods can be used to successfully answer the most pressing questions that we face in the clinic today.
Our first main area of investigation is transcriptional regulation of critical lethal prostate cancer pathways by the histone demethylase lysine specific demethylase 1 (LSD1) and the androgen receptor (AR). For these studies, we use transcriptomal and chromatin profiling. Development of new therapeutics is a key goal of these studies.
Our second area of investigation is understanding treatment resistance. We use "co-clinical" trials with prostate cancer xenografts and metastatic tissue samples collected prospectively from human prostate cancer patients treated with therapeutic agents. Then, we use an integrative systems biology approach to understand emergent resistance mechanisms. Development of novel treatment combinations is a key goal of these studies.
Finally, we are attempting to identify specific subsets of fatal prostate cancer. Development of biomarkers that can be used to improve prognostication and treatment selection of patients is a key goal of these studies.