OHSU

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Anthony P. Barnes, Ph.D.

Assistant Professor
Admin Unit: SOM-Pediatrics Department
Phone: 503-346-0753
Mail Code: 555 Hatfield/NRC5
Programs:
Neuroscience Graduate Program
Research Interests:
development development neurobiology cortical migration neuronal signaling
Preceptor Rotations
Dr. Barnes has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Barnes has not indicated availability as a mentor at this time.
Profile

Biography

Anthony Barnes is an Assistant Professor in the Department of Pediatrics. After receiving his B.S. degree in Physics at Tulane University in New Orleans, he enrolled in the Interdisciplinary Neuroscience Program at LSU Health Sciences Center.  In 2001, he left the cajun and creole influences of Louisiana for the rolling hills of Chapel Hill, North Carolina. At the University of North Carolina, Dr. Barnes spent his time working to understand protein trafficking and polarized cell signaling in epithelial cells and neurons, first with Dr. Sharon Milgram, and later with Dr. Franck Polleux. During his last year at UNC, he served as a fellow of the Christopher and Dana Reeve Foundation exploring signaling pathways involved in axon formation.

Current Research

The cells of the developing nervous system are bombarded by a myriad of external signals during their migration and differentiation. Deciphering how these cells interpret and respond to these signals provides insight into the mechanisms shaping brain development and responses following injury. The Barnes laboratory identifies and characterizes genes that are required for the proper formation and connectivity of the developing cerebral cortex. A major focus of the lab is directed toward mapping the pathways that link extra-cellular stimuli to alterations in gene expression and cytoskeletal rearrangement during neuronal differentiation. Neuronal polarity is a fundamental aspect of differentiation and function. In the last decade, neuroscientists have begun to discover the signaling cascades crucial for the ultimate establishment of the structural and functional distinctions of dendrites and axons. My laboratory combines an array of techniques from conditional gene deletion to cell biology and proteomics to probe the role of various signals in neuronal polarization.

Selected Publications

Barnes AP, Solecki D, Polleux F. (2008) New insights into the molecular mechanisms specifying neuronal polarity in vivo. Curr Opin Neurobiol. 18: 44-52.

Barnes AP, Lilley BN, Pan YA, Plummer LJ, Powell AW, Raines AN, Sanes JR, Polleux F.  LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. (2007) Cell. 129: 549-63.

Barnes AP, Livera G, Huang P, Sun C, O'Neal WK, Conti M, Stutts MJ, Milgram SL. Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. (2005) J Biol Chem. 280: 7997-8003.