Graduate Studies Faculty
Stephanie J. Murphy, VMD, PhD
Research Interests:sex differences, cerebral ischemia, stroke, preconditioning, alcohol
Preceptor RotationsDr. Murphy has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Murphy has not indicated availability as a mentor at this time.
Dr. Stephanie Murphy received her VMD (veterinary medicine) in 1994 and her PhD (Biochemistry) in 1996 as part of the Veterinary Medical Scientist Training Program at the University of Pennsylvania. She then completed a 4 year postdoctoral fellowship in the Comparative Medicine Department at the Johns Hopkins University School of Medicine in 2000 prior to becoming an Assistant Professor within the Anesthesiology & Critical Care Medicine Department at Johns Hopkins. In 2003, she joined the research faculty within the Department of Anesthesiology & Perioperative Medicine (APOM) at OHSU. She also holds joint appointments in the Departments of Comparative Medicine and Behavioral Neuroscience and a faculty appointment with the Neuroscience Graduate Program. She is a Diplomate of the American College of Laboratory Animal Medicine and the Director of the APOM Core Animal Laboratories and Training. Dr. Murphy was also the Associate Director for the Translational Modeling Program for the OHSU Research Center for Gender Based Medicine until it was disbanded in January 2011.
Dr. Murphy's research for the past 17 years has focused on gender biology and its relevance to cerebrovascular disease outcomes. As an independent researcher, she has focused on molecular mechanisms underlying sex differences in cerebrovascular diseases in immature, mature, and aging brain. For example, her previous work has established the underlying basic science for sex differences and the role of sex steroids in anesthetic preconditioning and perioperative stroke. Dr. Murphy is currently examining how the evolution of post-ischemic inflammatory cycling between the brain and peripheral immune system is strongly influenced by biological sex, including sexually dimorphic immune cell subsets and key inflammatory mechanisms that affect brain-spleen-brain cycling of inflammatory cells after focal cerebral ischemia. She is also exploring how endogenous regulatory B-cells limit infarct size in following brain ischemia by controlling immune-mediated inflammation triggered both in the CNS and in peripheral immune organs by focal stroke. In addition to her work on stroke immunology, Dr. Murphy is also investigating a novel astrocyte-specific mechanism linking testosterone exposure during brain development to microRNA 29 mediated regulation of de novo DNA methylation enzymes, subsequent epigenetic modifications and gene expression responsible for shaping ischemic sensitivity of astrocytes directly and of neurons indirectly. Clinically, she is recognized for her expertise in animal stroke models, rodent surgery and anesthesia and breeding management of genetically engineered mouse colonies. Dr. Murphy has published more than four dozen articles, reviews and book chapters related to her research and clinical interests.