OHSU

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John V. Brigande, PhD

Associate Professor of Otolaryngology
Associate Professor of Cell and Developmental Biology
Admin Unit: SOM-Otolaryngology & Head & Neck Surgery Department
Phone: 503-494-2933
Lab Phone: 504-494-4568
Fax: 503-494-5656
Office: Hatfield Research Center 414, 433
Mail Code: NRC04
Programs:
Cell & Developmental Biology
Neuroscience Graduate Program
Program in Molecular & Cellular Biosciences
Research Interests:
inner ear development cell fate specification in utero gene transfer in vivo electroporation molecular embryology virology » Click here for more about Dr. Brigande's research
Preceptor Rotations
Academic Term Available Spring 2014 Yes
Faculty Mentorship
Dr. Brigande is available as a mentor for 2013-2014.
Profile

Training

John Brigande (brigande@ohsu.edu ) joined the Oregon Hearing Research Center in 2003 and currently holds the position of Associate Professor of Otolaryngology and is jointly appointed as Associate Professor of Cell and Developmental Biology. He earned his Ph.D. from Boston College (Chestnut Hill, MA) in 1997 after completing his Bachelor of Science and Master's Degrees at the same institution. John's postdoctoral training was in Developmental Genetics (University of Texas, Austin) with Karen Artzt and later in Developmental Biology (Purdue University, West Lafayette, IN) with Donna Fekete. There he became interested in gene delivery into the developing mouse inner ear.

Research Interests
The Brigande lab vision is to establish gain and loss of function experimental paradigms to define gene function in the developing mammalian inner ear. To address these goals, plasmids and viruses are injected with a micropipette into the developing mouse otic vesicel in utero.  This technique enables us to evaluate embryos prenatally or pups postnatally to identify genes critical for morphogenesis and cell fate specification. Efforts to define pharmacological and gene-based therapeutics to restore inner ear function in congentially deaf mouse models are promising.