Graduate Studies Faculty

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Dennis Bourdette, M.D.

Chairman and Roy &Eulalia Swank Family Research Professor
Director, MS Center of Oregon
Admin Unit: SOM-Neurology Department
Phone: 503.494.7321
Fax: 503.494.7242
Office: Sam Jackson Hall, Rm 4243B
Mail Code: L226
Neuroscience Graduate Program
Research Interests:
multiple sclerosis, experimental autoimmune encephalomyelitis, axonal degeneration, demyelination, neuroimmunology, mitochondria, neuroprotection, medical, Neurobiology of Disease » Click here for more about Dr. Bourdette's research
Preceptor Rotations
Dr. Bourdette has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Bourdette has not indicated availability as a mentor at this time.

Dr. Bourdette is Chairman and Roy & Eulalia Swank Family Research Professor of the Department of Neurology, as well as a staff neurologist at the VA Medical Center in Portland, Oregon.  He is also Director of the Multiple Sclerosis Center of Oregon and co-Director of the Multiple Sclerosis Center for Excellence-West located at the Portland VA Medical Center

He is a graduate of the University of California-Davis, School of Medicine, completed his neurology residency at OHSU and was a post-doctoral fellow in neuroimmunology at the Portland VA Medica Center.  His area of special interest is the immunopathogenesis and treatment of multiple sclerosis and other neuroimmunologic diseases.

Recent Publications

Salinthone S, Yadav V, Bourdette DN, Carr DW. (2008) Lipoic acid:  a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.  Endocr  Metab Immune Disord Drug Targets 8, 132-42.

Salinthone S, Schillace RV, Marracci G, Bourdette D, Carr DW. (2008) Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells.  J Neuroimmunol  199, 46-55.

Forte, M, Gold BG, Marracci G, Chaudhary P, Basso E, Johnsen D, Yu X, Fowlkes J, Bernardi P and Bourdette D (2007).  Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proc. Nat. Acad. Sci. U.S.A. 104, 7558-7563.

Chaudhary P, Marracci GH and Bourdette DN (2006).  Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental allergic encephalomyelitis.  J Neuroimmunol 175, 87-96.

Marracci GH, McKeon GP, Marquardt WE, Winter RW, Riscor MK and Bourdette DN (2004). Alpha Lipoic Acid Inhibits Human T-cell Migration: Implications for Multiple Sclerosis.  J Neurosci Res, 78, 362-370.

Yadav V, Marracci G, Lovera J, Woodward W, Bogardus K, Marquardt W, Shinto L, Morris C and Bourdette D (2005). Lipoic acid in multiple sclerosis: a pilot study. Mult Scler 11, 159-165.