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Scott Wong, PhD
Admin Unit: SOM-Molecular Microbiology & Immunology Department
Office: VGTI Rm 1212C
Mail Code: VGTI
Molecular Microbiology & Immunology
Program in Molecular & Cellular Biosciences
Research Interests: The long-term goal of the Wong laboratory is to understand how herpesviruses cause disease in immunocompromised humans. This is important in developing effective antiviral therapies and potential vaccines. Herpesviruses, however, are very specific for their natural hosts, a factor that complicates the ability to study the mechanisms of the human viruses in an animal model. An alternative approach is to utilize animal models that harbor viruses that are closely related to the human form. One animal model that has proven to be important in understanding the mechanisms of infectious disease is the nonhuman primate. The Wong laboratory focuses on understanding how two simian herpesviruses, rhesus cytomegalovirus (CMV) and rhesus rhadinovirus (RRV), a homologue of human Kaposi's sarcoma-associated herpesvirus (KSHV), cause disease in immunocompromised rhesus monkeys. Utilizing molecular, genetic and virological techniques, the laboratory examines how these viruses infect and replicate in cell culture, and how they cause illnesses in animals. Studies conducted by the laboratory have shown that inoculation of immunocompromised monkeys with these viruses results in disease symptoms that closely resemble those observed in humans infected with the human immunodeficiency virus (HIV). Utilizing this two-pronged approach, the laboratory is identifying the viral determinants that contribute to disease.
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Dr. Wong has not indicated availability for preceptor rotations at this time.
Dr. Wong has not indicated availability as a mentor at this time.