Graduate Studies Faculty
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John Bissonnette, M.D.
Professor Obstetrics & Gynecology and Cell & Developmental Biology
Admin Unit: SOM-Obstetrics & Gynecology Department
Email: bissonne@ohsu.edu
Phone: 503 494 2101
Fax: 503 494 5296
Office: Baird Hall, 3030C
Mail Code: L458
Programs:
Cell & Developmental BiologyResearch Interests:
neural control of respiration, transgenic mice, Rett syndrome, methyl-CpG-binding protein 2,brain derived neurotrophic factor, g-aminobutyric acid, neuronal inhibition and respiratory pattern, role of astrocytes in chemosensitivity » Click here for more about Dr. Bissonnette's researchPreceptor Rotations
Dr. Bissonnette has not indicated availability for preceptor rotations at this time.Faculty Mentorship
Dr. Bissonnette has not indicated availability as a mentor at this time.Profile
Our lab is interested in the neural control of respiration. Studies are conducted in transgenetic mice. Current work is centered on animals deficient in the transcription factor methyl-CpG-protein 2 (Mecp2). The gene that encodes this DNA binding protein is mutated in the X-linked disorder Rett syndrome, whose phenotype includes disturbances in respiration.Current studies are examining the relationship between GABA inhibition of inspiratory neurons and the periodic breathing pattern in Mecp2+/- . A separate project looks at the expression of brain-derived neurotrophic factor transcripts using a respiratory plasticity protocol.Selected Publications:
Bissonnette JM, SJ Knopp. Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Pediatric Research 59: 513-518, 2006
Bissonnette JM, SJ Knopp, J Maylie, T Thong. Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Autonomic Neuroscience: Basic and Clinical, 136:82-89, 2007
Bissonnette JM, SJ Knopp. Effect of inspired oxygen on periodic breathing in methyl-CpG-binding protein 2 (Mecp2) deficient mice. J Applied Physiol 104:198-204, 2008
Bissonnette JM, SJ Knopp. Effect of inspired oxygen on periodic breathing in methyl-CpG-binding protein 2 (Mecp2) deficient mice. J Applied Physiol 104:198-204, 2008
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