Graduate Studies Faculty
John Bissonnette, M.D.
Programs:Cell & Developmental Biology
Research Interests:neural control of respiration, transgenic mice, Rett syndrome, methyl-CpG-binding protein 2,brain derived neurotrophic factor, g-aminobutyric acid, neuronal inhibition and respiratory pattern, role of astrocytes in chemosensitivity » Click here for more about Dr. Bissonnette's research
Preceptor RotationsDr. Bissonnette has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Bissonnette has not indicated availability as a mentor at this time.
ProfileOur lab is interested in the neural control of respiration. Studies are conducted in transgenetic mice. Current work is centered on animals deficient in the transcription factor methyl-CpG-protein 2 (Mecp2). The gene that encodes this DNA binding protein is mutated in the X-linked disorder Rett syndrome, whose phenotype includes disturbances in respiration.Current studies are examining the relationship between GABA inhibition of inspiratory neurons and the periodic breathing pattern in Mecp2+/- . A separate project looks at the expression of brain-derived neurotrophic factor transcripts using a respiratory plasticity protocol.
Bissonnette JM, SJ Knopp. Effect of inspired oxygen on periodic breathing in methyl-CpG-binding protein 2 (Mecp2) deficient mice. J Applied Physiol 104:198-204, 2008
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