Graduate Studies Faculty
John Bissonnette, M.D.
Programs:Cell & Developmental Biology
Research Interests:neural control of respiration, transgenic mice, Rett syndrome, methyl-CpG-binding protein 2,brain derived neurotrophic factor, g-aminobutyric acid, neuronal inhibition and respiratory pattern, role of astrocytes in chemosensitivity » Click here for more about Dr. Bissonnette's research
Preceptor RotationsDr. Bissonnette has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Bissonnette has not indicated availability as a mentor at this time.
Our lab is interested in the neural control of respiration. Studies are conducted in transgenetic mice. Current work is centered on animals deficient in the transcription factor methyl-CpG-protein 2 (Mecp2). The gene that encodes this DNA binding protein is mutated in the X-linked disorder Rett syndrome, whose phenotype includes disturbances in respiration. Current studies are examining the role of Mecp2 expression in astrocytes and separately in neurons in the depressed carbon dioxide chemosensitivity of Mecp2 deficient mice.
Lioy DT, SK Garb, CE Monaghan, J Raber, KD Foust, BK Kaspar, PG Hirrlinger, F Kirchhoff, JM Bissonnette, N Ballas, G Mandel: A role for glia in the progression of Rett syndrome. Nature 475:497-500, 2011
Vermehren-SchmaedickA, VK Jenkins, SJ. Knopp, A Balkowiec, JM Bissonnette. Intermittent hypoxia-induced expression of Brain-Derived Neurotrophic Factor is disrupted in the brainstem of MeCP2-deficient mice. Neuroscience 206:1-6, 2012
Toward MA, AP Abdala, SJ Knopp, JFR Paton, JM Bissonnette Increasing brain serotonin corrects CO2 chemosensitivity in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Exp Physiol 98: 842-849, 2013
Garg SK, Lioy DT, Cheval H, McGann JC, Bissonnette JM, Murtha MJ, Foust KD, Kaspar BK, Bird A, Mandel G. Systemic delivery of MeCP2 rescues behavioral and cellular defects in female mouse models of Rett syndrome. J Neurosci 33:13612-13620, 2013
Levitt ES, Hunnicutt BJ, Knopp SJ, Williams JT, Bissonnette JM. A selective 5-HT 1a receptor agonist improves respiration in a mouse model of Rett syndrome. J Appl Physiol 115:1626-1633, 2013
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