Graduate Studies Faculty
Mitchell S. Turker, PhD, JD
Programs:Molecular & Medical Genetics
Program in Molecular & Cellular Biosciences
Research Interests:Mutatagenesis; DNA repair; DNA methylation; Gene silencing; Environmental exposure; radiation effects » Click here for more about Dr. Turker's research » PubMed Listing
Preceptor RotationsDr. Turker has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Turker has not indicated availability as a mentor at this time.
I am interested in the mechanisms of abnormal gene inactivation and the relevance of these events to cancer. Abnormal gene inactivation results from two distinct types of events. The first is DNA mutation, which represents a change in the structure of DNA that alters expression of a given gene. The second type of event is epigenetic silencing, which involves loss of gene expression without alteration of the gene sequence. With regards to mutational events, we are interested in both endogenous and exogenous genotoxins that can affect the frequency and types of mutations that occur within the animal. A current focus is on how accelerated particles in space cause large-scale genomic damage that could affect astronauts during prolonged space travel. Our work with epigenetic silencing focuses on how silencing is initiated and determining the pathways that cause active genes to become aberrantly turned off.
Dr. Turker received his PhD in Pathology from the University of Washington (UW) and was a post-doctoral fellow at the University of Colorado Health Sciences Center. He served as a Research Instructor in the Department of Pathology at UW. He went on to the University of Kentucky where he served as an Assistant Professor and Associate Professor in the Departments of Pathology and Microbiology/Immunology and Director, Experimental Pathology. Prior to joining CROET, he was a visiting Associate Professor in the Department of Genetics and Development at Columbia University. Dr. Turker received a JD from Lewis and Clark Law School in May 2008 with a certificate in Environmental Law.