Graduate Studies Faculty

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Dennis R. Trune, Ph.D., M.B.A.

Professor of Otolaryngology
Admin Unit: SOM-Otolaryngology & Head & Neck Surgery Department
Phone: 503-494-2931
Fax: 503-494-5656
Office: Hatfield Research Center, Rm 416
Mail Code: NRC04
Research Interests:
hearing, middle and inner ear, otitis media, treatments for hearing loss, immunology of the ear, medical » Click here for more about Dr. Trune's research » PubMed Listing
Preceptor Rotations
Dr. Trune has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Trune has not indicated availability as a mentor at this time.
Profile

Summary of Current Research

My research interests involve inflammatory diseases of the auditory system. One area of focus is the impact of systemic immune diseases on cochlear function and how therapeutic steroids reverse these forms of hearing loss. We study hearing loss in mouse models of spontaneous autoimmune disease, as well as mice in which hearing loss is secondary to immune system dysfunction.  We also are investigating the immune processes of middle ear disease (otitis media) and how this inflammation impacts the inner ear.

Recent Publications

Trune, D.R., Kempton, J.B., Gross, N.D. Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear. Hearing Research, 212:22-32, 2006.

Hargunani, C.A., DeGagne, J.M., Kempton, J.B., Trune, D.R. Intratympanic injection of dexamethasone: time course of inner ear distribution and conversion to its active form. Otology & Neurotology, 27:564-9, 2006.

MacArthur, C.J., Hefeneider, S.H., Kempton, B., Trune, D.R. C3H/HeJ mouse model for spontaneous chronic otitis media. Laryngoscope, 116:1071-1079, 2006.

MacArthur, C.J., Hefeneider, S.H., Kempton, B., Parrish, S.K., McCoy, S., Trune, D.R. Evaluation of the mouse model for acute otitis media. Hearing Research, 219:12-23, 2006.

MacArthur, C.J., Trune, D.R. Mouse Models of Otitis Media. Current Opinion in Otolaryngology Head & Neck Surgery, 14:341-346, 2006.

Ghaheri, B., Kempton, J.B., Pillers, D.M., Trune, D.R. Cochlear cytokine gene expression in murine acute otitis media. Laryngoscope, 117:22-29, 2007.

Trune, D.R., Kempton, B., Harrison, A.R., Wobig, J.L. Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H/HeJ mice. Hearing Research, 226:209-217, 2007.

Kim, H.H., Addison, J., Suh E, Trune, D.R., Richter, C-P. Otoprotective effects of dexamethasone in the management of pneumococcal meningitis: an animal study. Triologic Thesis, Laryngoscope, 117:1209-1215, 2007.

Ghaheri, B., Kempton, J.B., Pillers, D.M., Trune, D.R. Cochlear cytokine gene expression in murine chronic otitis media. Otolaryngology Head Neck Surgery, 137:332-337, 2007.

MacArthur, CJ, Pillers, D.M., Pang, J., DeGagne, J.M., Kempton, J.B, Trune, D.R. Gram-negative Pathogen Klebsiella oxytoca is Associated with Spontaneous Chronic Otitis Media in Toll-Like Receptor 4 Deficient C3H/HeJ mice. Acta Otolaryngologica, In Press, 2007.

Education

  • Ph.D., Louisiana State University, 1979

Previous Positions

Non-Academic Interests