Graduate Studies Faculty
Mathew Thayer, PhD
Programs:Biochemistry & Molecular Biology
Molecular & Medical Genetics
Neuroscience Graduate Program
Program in Molecular & Cellular Biosciences
Research Interests:Chromosome Structure Genome stability cell cycle checkpoints DNA replication; cellular; medical » PubMed Listing
Preceptor RotationsDr. Thayer has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Thayer has not indicated availability as a mentor at this time.
Summary of Current Research
In addition, we recently found that exposing cells to radiation can also result in this abnormal chromosome duplication problem. Chromosome duplication is central to cell division and is tightly regulated when cells divide. Our work indicates that these chromosomes that duplicate at the wrong time are prone to break during cell division, and as a result become extensively rearranged. The consequence to the cell of having one of these chromosomes is that new chromosome alterations occur quite frequently, thereby resulting in the generation of many new mutations. Therefore, our work has identified a process that occurs in both cancer cells and in cells exposed to radiation, and therefore can explain the genetic instability that occurs in both cancer cells and in cells exposed to radiation. In our most recent work, we have developed a “chromosome engineering” system that allows us to create chromosomes with this duplication problem in a controlled manner.Recent Publications
Kevin S. Breger, Leslie Smith, Mitchell S. Turker, and Mathew J. Thayer. (2004). Ionizing Radiation Induces Frequent Translocations with Delayed Replication and Condensation. Cancer Research, 64, 8231–38.
David Kuninger, Daniel Stauffer, Siavash Eftekhari, Elizabeth Wilson, Mathew Thayer, and Peter Rotwein. (2004). Gene disruption by regulated siRNA expression using a two-adenovirus system. Human Gene Therapy, 15:1287-1292.
Macpartlin M, Zeng SX, Lee H, Stauffer D, Jin Y, Thayer M, Lu H. p300 regulates p63 transcriptional activity. J Biol Chem. 2005 Jun 17; 280:30604-10.
Breger, K. S., Smith, L. G., and Thayer, M. J. Engineering Translocations with Delayed Replication Timing: Evidence for cis Control of Replication Timing. (2005). Hum Mol Genet. 14: 2813-27.
Chang, B.H., Smith, L., Huang, J. and Thayer, M. Chromosomes with delayed replication timing lead to checkpoint activation, delayed recruitment of Aurora B and chromosome instability. (2006) Oncogene, Sep 25; [Epub ahead of print].
Stauffer D, Chang B, Huang J, Dunn A, Thayer M. P300/CBP interacts with ATR and is required for the DNA replication checkpoint. 1: J. Biol. Chem. 2007 Jan 31; [Epub ahead of print]
Graduate Education: University of Southern California; Department of Microbiology; Los Angeles, CA; Graduated June, 1988; Doctor of Philosophy in Microbiology; Dr. R.E.K. Fournier, PhD, advisor