Graduate Studies Faculty
Mary Stenzel-Poore, Ph.D.
Programs:Molecular Microbiology & Immunology
Neuroscience Graduate Program
Program in Molecular & Cellular Biosciences
Research Interests:Inflammatory responses to brain injury. Ischemic preconditioning and endogenous neuroprotection. Immune responses to stroke. Genomic response to brain injury and repair. medical, Neurobiology of Disease » Click here for more about Dr. Stenzel-Poore's research » PubMed Listing
Preceptor RotationsDr. Stenzel-Poore has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Stenzel-Poore has not indicated availability as a mentor at this time.
Summary of Current Research
The focus of my research program is to investigate the effects of neuroendocrine hormones involved in the stress response on immune development and function. One of the critical players in neuro-immune regulation is the neuroendocrine hormone, corticotropin-releasing hormone (CRH). This hormone is the central mediator of the stress response. We have created a transgenic mouse model which overproduces CRH and thus mimics animals undergoing a stress response. These animals are a genetic model of stress and stress-related behavior. We are investigating the ability of these mice to withstand infectious challenge with bacterial pathogens and viral disease. In addition, we have recently discovered a new receptor for CRH (CRH-R2) that is located outside of the brain and may mediate the peripheral actions of CRH. We have found that this receptor is expressed in the heart, skeletal muscle, endothelial cells and macrophages which suggests novel functions for this hormone involving inflammation and cardiovascular regulation. We are currently characterizing the function and regulation of CRH-R2 in cardiac myocytes. Our long term goal is to identify the health risks of chronic stress and help develop strategies to minimize the impact of stress on immune and cardiovascular function.
- Ph.D., Oregon Health & Science University, 1986