Graduate Studies Faculty
H. Scott Stadler, PhD
Programs:Molecular & Medical Genetics
Program in Molecular & Cellular Biosciences
Research Interests:Function of HOX proteins in development and disease. Skeletal tissue formation and regeneration, hepatocellular carcinoma, hypospadias, vesicouretal reflux. » PubMed Listing
Preceptor RotationsDr. Stadler has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Stadler has not indicated availability as a mentor at this time.
My laboratory is focused on developing tissue-specific therapies using the molecular and developmental functions of vertebrate Hox proteins to facilitate tissue repair or to treat a HOX-derived disease state. The Hox proteins are an evolutionarily conserved group of helix turn helix transcription factors that exhibit remarkable conservation in sites of expression, chromosomal clustering, and loss of function phenotypes in both vertebrate and invertebrate species.
In mice, there are 39 Hox genes, all of which have been “knocked out” by gene targeting. In the absence of an individual Hox protein, specific tissues fail to form in the embryo, providing evidence that these proteins play an essential role in the formation of discrete embryonic regions. How Hox proteins actually control the formation of specific embryonic regions is poorly understood. Indeed, while it is known that Hox proteins bind DNA and facilitate gene expression, the actual DNA sequences bound by these proteins, as well as the interacting factors that help modulate specific transcriptional functions, are largely unknown. By defining the DNA sequences used by these transcription factors, the target genes and developmental processes regulated by these proteins can be identified. The identification of individual HOX programs will provide a molecular basis for defects caused by the loss of HOX protein function while also providing mechanisms for therapy to repair tissues affected by injury or disease.