Graduate Studies Faculty

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Stephen M. Smith, M.B., B.S., Ph.D.

Associate Professor, Division of Pulmonary & Critical Care Medicine
Department of Physiology & Pharmacology
Admin Unit: SOM-DOM Pulmonary and Critical Care Medicine
Phone: 503 494 2736
Lab Phone: 503 494 2914
Office: BRB 321
Mail Code: UHN-67
Physiology & Pharmacology
Program in Molecular & Cellular Biosciences
Research Interests:
Calcium, Calcium receptor, synpatic transmission, synaptic plasticity, GPCR, subarachnoid hemorrhage » Click here for more about Dr. Smith's research » PubMed Listing
Preceptor Rotations
Dr. Smith has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Smith is available as a mentor for 2013-2014.


Stephen Smith completed  his graduate studies and medical degree at the University of Newcastle upon Tyne, UK. He was a postdoctoral fellow at the National Institute for Medical Research, London and the Department of Molecular and Cellular Physiology at Stanford University. He completed postgraduate medical training in London and Sydney. Dr Smith's research focus is the study of synaptic function. He is particularly interested in regulation of synaptic efficacy and how this is modulated in disease states. He continues this work in his laboratory in the Division of Pulmonary & Critical Care Medicine.

Recent Publications

Williams, C., Chen, W., Lee, C.H., Yaeger, D., Vyleta, N., Smith, S.M.(2012) Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. Nature Neuroscience, 15, 1195-1197.

Vyleta, N., Smith, S.M. (2011) Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor. Journal of Neuroscience, 31, 4593-4606.
Chen, W., Bergsman, J.B., Wang, X., Gilkey, G.M., Pierpoint, C.R., Daniel, E.A., Awumey, E.M., Dauban, P., Dodd, R.H., Ruat, M., Smith, S.M. (2010) Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals. PLoS ONE, 5(1), e8563.
Peters, J.H., McDougall, S.J., Fawley, J.A., Smith, S.M., Andresen, M.C. (2010) Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at brainstem neurons. Neuron, 65, 657-669.
Smith, S.M., Renden, R., von Gersdorff, H. (2008) Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval. Trends in Neurosciences, 31(11): 559-68.
Phillips, C.G, Harnett, M.T., Chen, W., Smith, S.M. (2008) Extracellular Calcium-sensing receptor modulates excitatory synaptic transmission. Journal of Neuroscience, 28(46): 12062-12070.