Graduate Studies Faculty

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Stephen M. Smith, M.B., B.S., Ph.D.

Professor, Division of Pulmonary & Critical Care Medicine
Department of Physiology & Pharmacology
Admin Unit: SOM-DOM Pulmonary and Critical Care Medicine
Phone: 503 220 8262 ext 52361 or 09552361
Lab Phone: 503 220 8262 ext 58412 or 09558412
Office: Building 101 Room 529
Mail Code: R & D 24
Neuroscience Graduate Program
Physiology & Pharmacology
Program in Molecular & Cellular Biosciences
Research Interests:
Calcium, Calcium receptor, synaptic transmission, synaptic plasticity, GPCR, subarachnoid hemorrhage, cellular neuroscience » Click here for more about Dr. Smith's research » PubMed Listing
Preceptor Rotations
Dr. Smith has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Smith has not indicated availability as a mentor at this time.


Stephen Smith completed  his graduate studies and medical degree at the University of Newcastle upon Tyne, UK. He was a postdoctoral fellow at the National Institute for Medical Research, London and the Department of Molecular and Cellular Physiology at Stanford University. He completed postgraduate medical training in London and Sydney. Dr Smith's research focus is the study of synaptic function. He is particularly interested in regulation of synaptic efficacy and how this is modulated in disease states. He continues this work in his laboratory in the Division of Pulmonary & Critical Care Medicine.

Recent Publications

Williams, C., Chen, W., Lee, C.H., Yaeger, D., Vyleta, N., Smith, S.M.(2012) Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. Nature Neuroscience, 15, 1195-1197.

Vyleta, N., Smith, S.M. (2011) Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor. Journal of Neuroscience, 31, 4593-4606.
Chen, W., Bergsman, J.B., Wang, X., Gilkey, G.M., Pierpoint, C.R., Daniel, E.A., Awumey, E.M., Dauban, P., Dodd, R.H., Ruat, M., Smith, S.M. (2010) Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals. PLoS ONE, 5(1), e8563.
Peters, J.H., McDougall, S.J., Fawley, J.A., Smith, S.M., Andresen, M.C. (2010) Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at brainstem neurons. Neuron, 65, 657-669.
Smith, S.M., Renden, R., von Gersdorff, H. (2008) Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval. Trends in Neurosciences, 31(11): 559-68.
Phillips, C.G, Harnett, M.T., Chen, W., Smith, S.M. (2008) Extracellular Calcium-sensing receptor modulates excitatory synaptic transmission. Journal of Neuroscience, 28(46): 12062-12070.