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Mark Slifka, PhD
Admin Unit: SOM-Molecular Microbiology & Immunology Department
Molecular Microbiology & Immunology
Program in Molecular & Cellular Biosciences
Research Interests: immunology virology vaccines diagnostics
Dr. Slifka has not indicated availability for preceptor rotations at this time.
Dr. Slifka has not indicated availability as a mentor at this time.
Profile The focus of my research is to determine the underlying mechanisms of humoral and cell-mediated immunity against acute viral infections. In this regard, we have developed murine models of acute viral infection and/or vaccination in order to address basic immunological questions related to the development and maintenance of long-term protective immunity. We have also developed a series of clinical studies in which we can study these issues directly in humans. During the course of these studies, we use a number of viruses including; arenaviruses (lymphocytic choriomeningitis virus, LCMV), flaviviruses (yellow fever virus and West Nile virus), and orthopoxviruses (vaccinia, cowpox, and monkeypox). The combination of basic research in animal models and applied research in clinical studies involving both healthy and immunocompromised populations has provided an excellent opportunity for defining the requirements for immunological memory as well as allowing us to learn how to develop more effective diagnostics and potential vaccine candidates.