Graduate Studies Faculty

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Larry Sherman, Ph.D.

Professor, Cell and Developmental Biology
Senior Scientist, Neuroscience, ONPRC
Admin Unit: SOM-Cell, Developmental & Cancer Biology Department
Phone: 503-690-5217
Lab Phone: 503-690-5536
Fax: 503-690-5384
Office: Cooley Building, ONPRC
Mail Code: 3
Cell & Developmental Biology
Neuroscience Graduate Program
Program in Molecular & Cellular Biosciences
Cancer Biology
Research Interests:
multiple sclerosis, Alzheimer's disease, myelination, demyelinating diseases, neurodegeneration, neural stem cells, oligodendrocytes, Schwann cells, astrocytes, neurons. Neurobiology of Disease » Click here for more about Dr. Sherman's research
Preceptor Rotations
Dr. Sherman has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Sherman is available as a mentor for 2016-2017.

Recent Publications:


  1. Back, S., Tuohy, T., Chen, H., Wallingford, N., Craig, A., Struve, J., Luo, N., Banine, F., Liu, Y., Chang, A., Trapp, B., Bebo, B., Rao, M. and Sherman, L. (2005). Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nature Med. 11:966-972.
  2. Struve, J., Maher, C., Li, Y., Kinney, S., Fehlings, M., Kuntz, C., and Sherman, L. (2005). Disruption of the hyaluronan-based extracellular matrix in spinal cord promotes astrocyte proliferation. Glia. 52:16-24.
  3. Matsumoto, S., Banine, F., Struve, J., Adams, C., Liu, Y., Metzger, D., Chambon, P., Rao, M. and Sherman, L.  (2006). Brg1 is required for murine neural stem cell differentiation and gliogenesis. Dev. Biol. 289:372-383.
  4. Su, W., Xing, R., Guha, A., Gutmann, D. and Sherman, L. (2007). Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with aging. Glia. 55:723-733.
  5. Deng, V., Matagne, V., Banine, F., Frerking, M., Ohlinger, P., Budden, S., Pevsner, J., Sherman, L. and Ojeda, S.R. (2007). FXYD1 is a MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum. Molec. Genet.  16:640-650.
  6. Cassiani-Ingoli, R., Muraro, P., Magnus, T., Reichert-Scrivner, S., Schmidt, J., Huh, J., Quandt, J., Bratincsak, A., Shahar, T., Eusebi, F., Hudson, L., Sherman, L., Mattson, M., Martin, R. and Rao, M. (2007). Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response. J. Neuropath. Exp. Neurol. 66:637-649.
  7. Segovia,  K., McClure, M., Moravec, M., Luo, N.L., Wan, Y., Gong, X., Riddle, A., Craig, A., Struve, J., Sherman, L. and Back, S. (2008). Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury. Ann. Neurol. 63:520-30.
  8. Bebo, B., Dehghani, B., Foster, S., Kurniawan, A., Lopez, F., Bebo, B. and Sherman, L.  (2009). Treatment with selective estrogen receptor modulators regulates myelin specific T-cells and suppresses experimental autoimmune encephalomyelitis. Glia. 57:777-790.
  9. Banine, F., Matagne, V., Sherman, L. and Ojeda, S. (2011). Brain region-specific expression of Fxyd1, an Mecp2 target gene, is regulated by epigenetic mechanisms.  J. Neurosci. Res. 89:840-51.
  10. Axthelm, M.K., Bourdette, D.N., Marracci, G.H., Su, W., Mullaney, E.T., Manoharan, M., Kohama, S.G., Pollaro, J., Witkowski, E., Wang, P., Rooney, W.D., Sherman, L.S. and Wong, S.W. (2011). Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a non-human primate. Ann. Neurol. 70:362-73.
  11. Back, S.A., Kroenke, C., Sherman, L., Gong, X., Lawrence, G., Sonnen, J.A., Larson, E.B. and Montine, T.J. (2011). Free radical injury and oligodendroglial reaction in white matter lesions defined by high-field strength MRI in older adults.  Ann. Neurol. 70:465-76.
  12. Dean, J.M., Riddle, A., Maire, J., Hansen, K.D., Preston, M., Barnes, A.P., Sherman, L.S. and Back, S.A. (2011). An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors. Molec. Neurodegen. 6:46
  13. Cargill, R., Kohama, S., Struve, J., Su, W., Banine, F., Witkowski, E., Back, S.A. and Sherman, L. (2012). Reactive astrocytes in aged primate gray matter synthesize excess hyaluronan linked to oligodendrocyte progenitor accumulation.  Neurobiol. Aging 33:830.e13-24
  14. Buser, J., Maire, B.S., Riddle, A., Gong, X., Ngyuen, T., Nelson, K., Luo, N.L., Ren, J., Struve, J., Sherman, L.S., Miller, S.P., Chau, V., Hendson, G., Ballabh, P., Grafe, M.R. and Back, S.A. (2012).  Arrested pre-oligodendrocyte maturation contributes to myelination failure in premature infants. Ann. Neurol. 71:93-109.
  15. Winkler, C., Foster, S., Xing, R., Matsumoto, S., Banine, F., Berny-Lang, M., Itakura, A., McCarty, O. and Sherman, LS. (2012). Hyaluronan anchored to CD44 on CNS vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis. J. Biol. Chem. 287:33237-51.
  16. Uchida, N., Chen, K., Hansen, K., Dean, J., Buser, J., Riddle, A., Beardsley, D., Wan, Y., Gong, X., Nguyen, T., Cummings, B., Anderson, A., Dohse, M., Tamaki, S., Matsumoto, S., Sherman, L.S., Kroenke, C. and Back, S.A. (2012). Human neural stem cells generate functional myelination in asymptomatic neonates and juvenile mice with severe dysmyelination. Science Trans. Med. 4:155ra136.
  17. Shen, W., Fruttiger, M., Zhu, L., Chung, S., Barnett, N., Kirk, J., Lee, S., Coorey, N., Killingsworth, M., Sherman, L.S., Gillies, M. (2012). Conditional Müller cell ablation causes independent neuronal and vascular pathologies in a novel transgenic model.  J. Neurosci. 32:15715-15727.
  18. Preston, M., Gong, X., Su, W., Matsumoto, S., Banine, F., Winkler, C., Foster, S., Xing, R., Struve, J., Dean, J., Baggenstoss, B., Weigel, P., Montine, T., Back, S. and Sherman, L.S. (2012). Digestion products of the PH20 hyaluronidase inhibit remyelination. Ann. Neurol. In Press.
  19. Kuwahara, Y., Banine, F., Rogers, A., Fletcher, C., Sherman, LS., Roberts, C. and Weissman, B.E. (2012). Establishment and characterization of mouse malignant rhabdoid tumor cell lines from genetically engineered mouse models and the influence of genetic background on their development.  Int. J. Cancer. In Press.
  20. Dayger, C., Rosenberg, J., Winkler, C., Foster, S., Witkowski, E., Benice, T., Sherman, LS. and Raber, J. (2012). Paradoxical effects of apolipoprotein E on cognitive function and clinical progression in mice with experimental autoimmune encephalomyelitis. Pharm. Biochem. Behav.In press.