Graduate Studies Faculty
John Belknap, PhD
Neuroscience Graduate Program
Research Interests:Genetics, Alcohol and Drug Abuse, Statistics, Microarray Analysis, QTL Analysis Mouse Models, Behavioral » PubMed Listing
Preceptor RotationsDr. Belknap has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Belknap has not indicated availability as a mentor at this time.
Pharmacogenetics; opioid analgesia; drug tolerance and dependence
Summary of Current Research
The Belknap lab is devoted to genetic studies of sensitivity to many effects of drugs subject to abuse using a wide range of genetic mouse models from knockouts to selected lines. The principal drugs for study are cocaine, methamphetamine, morphine and alcohol and the traits are those often associated with these drugs in humans, such as alcohol and morphine withdrawal, morphine analgesia, methamphetamine stereotypy, cocaine seizures and several other behaviors. One goal of this work is to detect and map to specific chromosomal regions the genes (polygenes) influencing these traits. These chromosomal regions are referred to as quantitative trait loci, or QTLs. Another goal is to determine the multiple drugs influenced by these QTLs, and how they interact with other genes (gene-gene interactions) throughout the genome. Since the organization of genes on chromosomes is highly similar between mouse and humans, mapped QTLs in the mouse often maps them in the human genome as well.
B.A. (1966) University of Colorado
M.A. (1969) University of Colorado
Ph.D. (1971) University of Colorado
Professor, Department of Pharmacology, University of North Dakota, Grand Forks
Assistant Professor, Department of Psychology, University of Texas at Austin