Graduate Studies Faculty
Mohammad I. Sabri, Ph.D.
Research Interests:Molecular and cellular mechanisms of nerve fiber degeneration in toxic neuropathy, neurotoxicology, neurotoxinsneurotoxins, environmental toxins, neuropathy, axonopathy, axon degeration, axonal transport, kinesin, dynein, cytoskeletal proteins, energy metabolism, neurodegenerative diseases, proteomics, genomics, 1,2-diacetylbenzene, 2,5-hexanrdione, acrylamide, 3-nitropropionic acid, oxidative stress, medical » PubMed Listing
Preceptor RotationsDr. Sabri has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Sabri has not indicated availability as a mentor at this time.
Summary of Current Research
Selected environmental chemicals and drugs are employed as experimental probes to investigate the molecular and cellular mechanisms of neuronal/axonal degeneration in neurodegenerative disease (e.g. Alzheimer's disease, Parkinson's disease, and ALS). Several pieces of recent evidence suggest a strong relationship between energy dysfunction and the onset of neurodegenerative disease. Since mitochondria (mt) are central to cellular energy metabolism, we have hypothesized that reduced energy supplies caused by the mt disruption triggers a cascade of events which leads to neuronal/axonal damage. Mitochondrial genome may be particularly vulnerable to the exposure to environmental chemicals since it is not well protected against DNA damage. My laboratory is currently investigating mechanisms of neurotoxicity of certain agents (cyanide/cyanate and sodium azide) that selectively disrupt the terminal phases of the mt electron transport chain, notably cytochrome c oxidase (COX). Immunocytochemical, histochemical, and in situ hybridization studies are underway to determine of the neurotoxicity of these agents is mediated by disrupting mt mRNA/DNA for COX-1, a subunit encoded by the mt genome.
- Ph.D., The Central Drug Research Institute, Lucknow, India, 1967