Graduate Studies Faculty

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Mohammad I. Sabri, Ph.D.

Removed per NGP
Admin Unit: Oregon Institute of Occupational Health Sciences
Research Interests:
Molecular and cellular mechanisms of nerve fiber degeneration in toxic neuropathy, neurotoxicology, neurotoxinsneurotoxins, environmental toxins, neuropathy, axonopathy, axon degeration, axonal transport, kinesin, dynein, cytoskeletal proteins, energy metabolism, neurodegenerative diseases, proteomics, genomics, 1,2-diacetylbenzene, 2,5-hexanrdione, acrylamide, 3-nitropropionic acid, oxidative stress, medical » PubMed Listing
Preceptor Rotations
Dr. Sabri has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Sabri has not indicated availability as a mentor at this time.
Profile

Summary of Current Research

Selected environmental chemicals and drugs are employed as experimental probes to investigate the molecular and cellular mechanisms of neuronal/axonal degeneration in neurodegenerative disease (e.g. Alzheimer's disease, Parkinson's disease, and ALS). Several pieces of recent evidence suggest a strong relationship between energy dysfunction and the onset of neurodegenerative disease. Since mitochondria (mt) are central to cellular energy metabolism, we have hypothesized that reduced energy supplies caused by the mt disruption triggers a cascade of events which leads to neuronal/axonal damage. Mitochondrial genome may be particularly vulnerable to the exposure to environmental chemicals since it is not well protected against DNA damage. My laboratory is currently investigating mechanisms of neurotoxicity of certain agents (cyanide/cyanate and sodium azide) that selectively disrupt the terminal phases of the mt electron transport chain, notably cytochrome c oxidase (COX). Immunocytochemical, histochemical, and in situ hybridization studies are underway to determine of the neurotoxicity of these agents is mediated by disrupting mt mRNA/DNA for COX-1, a subunit encoded by the mt genome.

Recent Publications

Education

  • Ph.D., The Central Drug Research Institute, Lucknow, India, 1967

Previous Positions

Non-Academic Interests