Graduate Studies Faculty
P. Hemachandra Reddy, Ph.D.
Programs:Neuroscience Graduate Program
Research Interests:Medical genetics, neurogenetics, aging, neurodegeneration, Alzheimer's disease, gene expression, mouse models, mitochondrial bioenergetics, mechanisms of fusion and fission, oxidative stress, cell and molecular biology, proteomics, medical » Click here for more about Dr. Reddy's research » PubMed Listing
Preceptor RotationsDr. Reddy has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Reddy has not indicated availability as a mentor at this time.
P. Hemachandra Reddy is an associate scientist in the Division of Neuroscience. He is also a faculty member of the Neuroscience Graduate Program. He received his B.Sc. and M.Sc. in biology from Sri Venkateswara University, Tirupati, India. He received an M.Phil in human cytogenetics from Delhi University. He was a commonwealth scholar (1990-1993) before receiving his Ph.D. (1994) in human genetics from London University. He did his postdoctoral training (1995-2000) at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. After his postdoctoral training, he joined the OHSU-Neurological Sciences Institute Faculty in July 2000, and joined the center in July 2008. Dr. Reddy has served as a standing member of the Veteran Affairs Merit Review Study Section, and also served on NIH study sections, including CDIN and NOMD. Currently, Dr. Reddy is an associate/academic editor for 6 journals, including Journal of Alzheimer’s Disease, Frontiers in Aging Neuroscience, PLoS ONE, Journal of Gerontology: Biological Sciences, BBA-Molecular Basis of Disease and Clinical Practice, and an editorial board member for 20 journals. Dr Reddy has also been a guest editor for several special topics 1) Mitochondrial Drugs for Neurodegenerative Diseases and 2) Genes, Mechanisms and Drugs for Asthma (for Pharmaceuticals published by MDPI), 3) Synaptic Damage in Aging and Neurodegenerative Diseases (for Frontiers in Aging Neuroscience), 4) Current Status of Therapeutics and Preventive Measures for Patients with Thalassaemia and Sickle Cell Disease (for Cardiovascular & Hematological Agents in Medicinal Chemistry) 5) Aging and Mitochondria in Alzheimer’s Disease (for Antioxidants & Redox Signaling).
CURRENT RESEARCH PROJECTS
Project 1.- Role of amyloid beta, synaptic pathology and mitochondrial dysfunction in Alzheimer's disease pathogenesis. Currently, my lab is investigating the roles of amyloid beta, synaptic pathology and mitochondrial oxidative damage in the development and progression of Alzheimer's disease (AD).
Project 2. - Mitochondrial therapeutics in Alzheimer's disease. My lab is also investigating to determine whether mitochondrially targeted antioxidants (MTAs) reduce oxidative damage and amyloid beta pathology, increase neurite outgrowth and ameliorate cognitive deficits in APP transgenic mice.
Project 3. - Mitochondrial dynamics in alcohol, aging and gender In another project, we are studying the mitochondrial DNA changes and mitochondrial dynamics (fission and fusion balance) in the brains of male and female, and young and aged nonhuman primates, nonhuman primates fed with ethanol, laboratory mice and humans, in order to determine the effect of age, gender and alcohol, in mitochondrial structure and function, and cell survival.
Project 4. Using postmortem brains from patients with Huntington's disease (HD) and transgenic mice from HD, the Reddy lab is exploring the role of abnormal mitochondrial dynamics in the progression of HD. Further, Reddy lab is also investigating the mechanisms of transport of mutant huntingtin oligomers into nucleus and other subcellular organelles in neurons affected by HD.
Project 5. Using primary neurons from transgenic mouse models of Aging, AD and HD and live-cell imaging tools, Reddy and colleagues are extensively investigating axonal transport of mitochondria, mitochondrial biogenesis and synaptic activity.
TECHNIQUES/APPROACHES USED IN THE LAB
My lab uses a variety of techniques/approaches, including molecular biology and cell biology, in situ hybridization, immunofluorescence, confocal/electron microscopy, and state-of-the art gene expression techniques. We work on primary neuronal cultures, and transgenic mouse models of Aging and Alzheimer's disease.
Mao P, Meshul C, Thuiller P, Goldberg NRS, Reddy PH (2012). CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria PLoS One 7 (1) e29343.
Mao P, Gallagher P, Nedungadi S, Manczak M, Shirendeb UP, Kohama SG, Ferguson B, Park BS, Reddy PH (2012). Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: Implications for aging. Biochim Biophys Acta. 1822, 111-119.
Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH (2011). Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Hum Mol Genet. 20, 4515-4529.
Calkins MJ, Reddy PH (2011). Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons. Biochim Biophys Acta. 1812, 507-513.
Shirendeb UP, Calkins MJ, Manczak M, Anekonda V, Dufour B, McBride JL, Mao P, Reddy PH (2012). Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease. Hum Mol Genet. 21, 406-420.
Shirendeb U, Reddy AP, Manczak M, Calkins MJ, Mao P, Tagle DA, Reddy PH (2011). Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage. Hum Mol Genet. 20, 1438-1455.
Manczak M, Calkins MJ, Reddy PH (2011). Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum Mol Genet. 20, 2495-2509.
Reddy PH, Reddy TP, Manczak M, Calkins MJ, Shirendeb U, Mao P (2011). Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res Rev. 67, 103-118.
Reddy PH(2011). Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain Res. 1415, 136-148.