Graduate Studies Faculty
Jacob Raber, Ph.D.
Neuroscience Graduate Program
Research Interests:Aging, Alzheimer's Disease, Androgen Receptor, Sex Differences, Histamine, apoE, Methamphetamine, Irradiation, Neurogenesis, Cognitive Function, Behavioral, circadian, high fat diet-induced cognitive impairments » PubMed Listing
Preceptor RotationsAcademic Term Available Winter 2014 Yes Spring 2014 Yes Fall 2015 Yes Summer 2015 Yes Fall 2014 Yes Spring 2015 Yes Winter 2015 Yes Summer 2016 Yes Fall 2016 Yes Winter 2016 Yes Spring 2016 Yes Summer 2017 Yes Fall 2017 Yes Winter 2017 Yes Spring 2017 Yes
Faculty MentorshipDr. Raber is available as a mentor for 2016-2017. Dr. Raber is available as a mentor for 2013-2014. Dr. Raber is available as a mentor for 2014-2015. Dr. Raber is available as a mentor for 2015-2016.
Summary of Current Research
Our research focuses on effects of genetic factors, such as apoE, and environmental factors, such as irradiation, drugs of abuse like methamphetamine, and high fat diet, on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these conditions. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.
We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.
Siegel, J.S., Park, B., Raber, J. (2011) Methamphetamine exposure during brain development alters the brain acetylcholine system in adolescent mice. Journal of Neurochemistry, 119, 89-99. http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2011.07418.x/full
Haley, G.E., McGuire, A., Berteau-Pavy, D., Weiss, A., Patel, R., Messaoudi, I., Urbanski, H.F., Raber, J. (2011) Measures of Anxiety, Amygdala Volumes, and Hippocampal Scopolamine phMRI Response in Elderly Female Rhesus Macaques. Neuropharmacology (Special Issue on anxiety and depression), 62, 385-390. PMCID: PMC3195963 http://www.sciencedirect.com/science/article/pii/S0028390811003479
Davis, M.J., Iancu, O.D., Acher, F., Stewart, B.M., Eiwaz, M.A., Duvoisin, R.M., Raber, J. (2012) Role of mGluR4 in acquisition of fear learning and memory. Neuropharmacology (Special mGluR issue), 66:365-72. PMCID: 3508079 [Available 2014/3/1]
Olsen, R., Agam, M., Davis, M.J.; Raber, J. (2012) ApoE Isoform-Dependent Deficits in Extinction of Contextual Fear Conditioning Genes, Brain, and Behavior, 7, 806-812. PMCID: PMC3642038 [Available 2013/10/1]
Haley, G.E., Yeiser, L., Olsen, R., Davis, M.J., Johnson, L.A., Raber, J. (2013) Early effects of whole body 56Fe irradiation on hippocampal function in C57BL/6J mice. Radiation Research, 179, 590-596.
Zuloaga, D.G., Siegel, J.A., Acevedo, S.F., Agam, M,, Raber, J. (2013) Developmental methamphetamine exposure results in short- and long-term alterations in hypothalamic-pituitary-adrenal axis-associated proteins. Develomental Neuroscience, 35, 338-346. http://www.karger.com/Article/FullText/351278
Johnson, L.A., Olsen, R.H., Markens, L., DeBarber, A., Steiner, R.D., PhD; Sullivan, P.M., Maeda, N., Raber, J. (2014) Apolipoprotein E - Low Density Lipoprotein Receptor Interaction Affects Spatial Memory Retention and Brain ApoE Levels in an Isoform-Dependent Manner. Neurobiology of Disease, 64, 150-162. http://www.sciencedirect.com/science/article/pii/S0969996114000035
Zuloaga, D.G., Johnson, L.A., Agam, M., Raber, J. (2014) Sex differences in activation of the Hypothalamic-Pituitary-Adrenal Axis by methamphetamine. Journal of Neurochemistry, 129, 495-508. http://onlinelibrary.wiley.com/doi/10.1111/jnc.12651/abstract
Raber, J., Rudobeck, E., Campbell-Beachler, M., Allen A.R., Allen, B., Rosi, S., Nelson, G.A., Ramachandran, S., Turner, J., Fike, J.R., Vlkolinsky, R. (2014) 28Silicon radiation-induced enhancement of synaptic plasticity in the hippocampus of naïve and cognitively tested mice. Radiation Research, 181, 362-368. http://www.bioone.org/doi/abs/10.1667/RR13347.1
Olsen, R.H.J., Marzulla, T., Raber, J. (2014) Impairment in extinction of contextual and cued fear following post-training whole body irradiation. Frontiers, 8:231. http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00231/full
Ph.D., 1991, The Weizmann Institute of Science, Rehovot, Israel
M.Sc., 1986, Free University, Amsterdam, The Netherlands
B.Sc., 1983, Free University, Amsterdam, The Netherlands
1991-1995 Postdoctoral Researcher, The Scripps Research Institute, La Jolla, CA.
1996-1998 Staff Research Investigator, Gladstone Molecular Neurobiology Program, San Francisco, CA; Adjunct Instructor of Neurology, University of California, San Francisco, California.
1998-2000 Staff Research Scientist I, Gladstone Institute of Neurological Disease, San Francisco, CA.
2000-2001 Staff Research Scientist II, Gladstone Institute of Neurological Disease, San Francisco, CA.
1998-2001 Assistant Adjunct Professor of Neurology, University of California, San Francisco, CA.