Graduate Studies Faculty
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Neuroscience Graduate Program
We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.
Acevedo, S.F., de Esch, I.J.P., Raber, J. (2007) Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure. Neuropsychopharmacology, 32, 665-672.
Berteau-Pavy, F., Park, B., Raber, J. (2007) Effects of sex and APOE e4 on object recognition and spatial navigation in the elderly. Neuroscience 147, 6-17.
Acevedo, S.F., Pfankuch, T., van Meer, P., Raber, J. (2008) Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem, 107, 976-986.
Rizk-Jackson, A., Robertson, J., Raber, J. (2008) Tfm-AR modulates the effects of apoE4 on cognition. J Neurochem, 105, 63-67.
Haley, G.E., Landauer, N., Renner, L., Weiss, A., Hooper, K., Urbanski, H.F., Kohama, S.G., Neuringer, M., Raber, J. (2009) Circadian activity associated with spatial learning and memory in aging Rhesus monkeys. Exp Neurol, 217, 55-62.
Siegel, J.A., Benice, T.S., van Meer, P., Park, B.S., Raber, J. (2009) Decreased muscarinic acetylcholine receptors and impaired performance in acetylcholine-modulated behavioral tasks in mice lacking apolipoprotein E. Neurobiol Aging, in press
Villasana, L., Rosenberg, J., Raber, J. (2009) Sex-dependent effects of 56Fe irradiation on contextual fear conditioning. Hippocampus, in press
Benice, T.S., Raber, J. (2009) Dihydrotestosterone modulates spatial working memory in male mice. J Neurochem, in press
Benice, T.S., Raber, J. (2009) Testosterone and dihydrotestosterone differentially improve cognition in aged female mice. Learning and Memory, in press
Non-Academic Interests
Jacob Raber, Ph.D.
Professor, Behavioral Neuroscience
Professor, Department of Neurology
Affiliate Scientist, Division of Neuroscience, ONPRC
Admin Unit: SOM-Behavioral Neuroscience Department
Email: raberj@ohsu.edu
Phone: 503 494-1524
Lab Phone: 503 494-1431
Fax: 503 494-6877
Office: MRB708
Mail Code: L470
Programs:
Behavioral NeurocienceNeuroscience Graduate Program
Research Interests:
aging, alzheimer's disease, androgen receptor, sex differences, histamine, apoE, methamphetamine, irradiation, neurogenesis, cognitive function, behavioral » PubMed ListingPreceptor Rotations
Academic Term Available Winter 2009 Yes Spring 2009 Yes Summer 2009 YesFaculty Mentorship
Dr. Raber is available as a mentor for 2008-2009. Dr. Raber is available as a mentor for 2009-2010.Profile
Summary of Current Research
Our research focuses on effects of genetic factors, such as apoE, and environmental factors on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these diseases. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.
Recent Publications
Villasana, L., Acevedo, S.F., Poage, C., Raber, J. (2006) Sex- and ApoE Isoform-dependent effects of radiation on cognitive function. Radiat Res 166, 883-891.Acevedo, S.F., de Esch, I.J.P., Raber, J. (2007) Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure. Neuropsychopharmacology, 32, 665-672.
Berteau-Pavy, F., Park, B., Raber, J. (2007) Effects of sex and APOE e4 on object recognition and spatial navigation in the elderly. Neuroscience 147, 6-17.
Acevedo, S.F., Pfankuch, T., van Meer, P., Raber, J. (2008) Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem, 107, 976-986.
Rizk-Jackson, A., Robertson, J., Raber, J. (2008) Tfm-AR modulates the effects of apoE4 on cognition. J Neurochem, 105, 63-67.
Haley, G.E., Landauer, N., Renner, L., Weiss, A., Hooper, K., Urbanski, H.F., Kohama, S.G., Neuringer, M., Raber, J. (2009) Circadian activity associated with spatial learning and memory in aging Rhesus monkeys. Exp Neurol, 217, 55-62.
Siegel, J.A., Benice, T.S., van Meer, P., Park, B.S., Raber, J. (2009) Decreased muscarinic acetylcholine receptors and impaired performance in acetylcholine-modulated behavioral tasks in mice lacking apolipoprotein E. Neurobiol Aging, in press
Villasana, L., Rosenberg, J., Raber, J. (2009) Sex-dependent effects of 56Fe irradiation on contextual fear conditioning. Hippocampus, in press
Benice, T.S., Raber, J. (2009) Dihydrotestosterone modulates spatial working memory in male mice. J Neurochem, in press
Benice, T.S., Raber, J. (2009) Testosterone and dihydrotestosterone differentially improve cognition in aged female mice. Learning and Memory, in press
Education
- Ph.D., 1991, The Weizmann Institute of Science, Rehovot, Israel
- M.Sc., 1986, Free University, Amsterdam, The Netherlands
- B.Sc., 1983, Free University, Amsterdam, The Netherlands
Previous Positions
- 1991-1995 Postdoctoral Researcher, The Scripps Research Institute, La Jolla, CA.
- 1996-1998 Staff Research Investigator, Gladstone Molecular Neurobiology Program, San Francisco, CA; Adjunct Instructor of Neurology, University of California, San Francisco, California.
- 1998-2000 Staff Research Scientist I, Gladstone Institute of Neurological Disease, San Francisco, CA.
- 2000-2001 Staff Research Scientist II, Gladstone Institute of Neurological Disease, San Francisco, CA.
- 1998-2001 Assistant Adjunct Professor of Neurology, University of California, San Francisco, CA.
Non-Academic Interests
- Photography.
