Graduate Studies Faculty
Thomas K. Baumann, Ph.D.
Research Interests:sensory neurophysiology, trigeminal pain, neuropathic pain, hyperalgesia, allodynia, ion channels, functional imaging » PubMed Listing
Preceptor RotationsDr. Baumann has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Baumann has not indicated availability as a mentor at this time.
Summary of Current Research
My laboratory investigates transduction and signaling by somatosensory primary afferent neurons. We use patch clamp recording, immunofluorescence, molecular biology and functional imaging techniques to study ion channels which are responsible for the transduction of chemical, mechanical and thermal stimuli. We also investigate how ion channels are modulated by inflammatory mediators. These studies are important for a better understanding of the cellular mechanisms that are involved in sensory transduction and primary hyperalgesia. In addition, we utilize two approaches for studying peripheral neural mechanisms of chronic pain. One approach focuses upon the biophysical, pharmacological and immunohistochemical characteristics of neurons obtained from diabetic animals and patients treated by ganglionectomy for intractable pain due to nerve injury. A second approach utilizes microneurographic recordings in patients with trigeminal neuralgia or complex regional pain syndrome. These more clinically oriented studies seek to elucidate the cause of abnormal action potential discharge in injured neurons.
Campero M, Baumann TK, Bostock H, Ochoa JL. 2009. Human cutaneous C fibres activated by cooling, heating and menthol. J Physiol 587:5633-5652.
Campero M, Bostock H, Baumann TK, Ochoa JL. 2010. A search for activation of C nociceptors by sympathetic fibers in complex regional pain syndrome. Clin Neurophysiol 121:1072-1079.
Campero M, Bostock H, Baumann TK, Ochoa JL. 2011. Activity-dependent slowing properties of an unmyelinated low threshold mechanoreceptor in human hairy skin. Neurosci Lett 493:92-96.
Jia Y, Baumann TK, Wang RK. 2010. Label-free 3D optical microangiography imaging of functional vasa nervorum and peripheral microvascular tree in the hind limb of diabetic mice. J Innov Optical Health Sci 3:307-313.
- Ph.D., Brain Research Institute, University of Zurich, Switzerland, 1983