OHSU

Graduate Studies Faculty

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Sergio R. Ojeda, D.V.M.

Division Head and Senior Scientist Division of Neuroscience
Admin Unit: Oregon National Primate Research Center
Office: West campus
Mail Code: L-584
Programs:
Cell & Developmental Biology
Neuroscience Graduate Program
Physiology & Pharmacology
Program in Molecular & Cellular Biosciences
Research Interests:
neuroendocrinology of female sexual development. Neuron-glial interactions. Neurotrophic factors and ovarian development. Systems Biology. Genetics and Molecular Biology » Click here for more about Dr. Ojeda's research » PubMed Listing
Preceptor Rotations
Dr. Ojeda has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Ojeda has not indicated availability as a mentor at this time.
Profile

Summary of Current Research

Dr. Ojeda's main area of interest is the neuroendocrine control of female sexual development. His research efforts are focused on two principal topics: a) the role of glial-neuronal interactions and intercellular signaling in the regulation of the hypothalamic neuronal network that produces luteinizing hormone-releasing hormone, the neuropeptide that controls reproductive function, and b) the regulation of ovarian function by the peripheral nervous system and target-derived neurotrophic factors. Both fields of study employ a combination of physiological, biochemical, cellular, molecular and genetic techniques. Currently, Dr. Ojeda's research program focuses on the involvement of growth factors and transcriptional regulators in controlling both the maturation of the reproductive hypothalamus and differentiation of ovarian functions.

Recent Publications

Mastronardi, G, GG Smiley, J Raber, T Kusakabe, A Kawagushi, V Matagne, A Dietzel, S Heger, AE Mungenast, R. Cabrera, S Kimura, and SR Ojeda. 2006. Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function. J Neurosci. 26:13167-13179.

Deng, V, V Matagne, F Banine, M Frerking, P Ohliger, S Budden, J Pevsner, L Sherman, and SR Ojeda.  2007. FXYD1 is a MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum Mol Genetics. 16:640-650. 

Garcia-Rudaz, C, F Luna, V Tapia, B Kerr, L Colgin, F Galimi, GA Dissen, ND Rawlings, and SR Ojeda. 2007.  Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis.  Development. 134:945-957.

Heger, S, C Mastronardi, GA Dissen, A Lomniczi, R Cabrera, CL Roth, H Jung, F Galimi, W Sippell, and SR Ojeda.  2007.  Enhanced at Puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis. J. Clin. Invest. 117:2145-2154.

Education

1968     University of Chile, School of Veterinary Medicine, Valdivia, Chile.  Doctor of Veterinary Medicine.

1972-1974  University of Texas Health Science Center at Dallas, Postdoctoral studies in Neuroendocrinology.

Previous Positions

1965‑1966         Student Assistantship in Morphology, Univ Austral, Chile

1967                 Student Assistantship in Physiology, Univ Austral, Chile

1968                 Instructor in Physiology (Jan‑June), Univ Austral, Chile

1968‑1971         Assistant Professor of Physiology, Univ Austral, Chile

1972‑1974         Postdoctoral Fellow, Department of Physiology, Univ Tx Hlth Sci Ctr at Dallas, Southwestern Medical School, Dallas, TX

1974‑1978         Assistant Professor of Physiology, Univ Tx Hlth Sci Ctr at Dallas, Southwestern Medical School

1978‑1982        Associate Professor of Physiology, Univ Tx Hlth Sci Ctr at Dallas, Southwestern Medical School

1982-1987        Professor of Physiology, Univ Tx Hlth Sci Ctr at Dallas, Southwestern Medical School

1987-present    Head, Neuroscience Div, ONPRC, OHSU, Beaverton, OR

Non-Academic Interests

Instructor T'ai Chi Ch'uan

Second Degree Black Belt Sheng Hun Kung Fu