Graduate Studies Faculty
Sergio R. Ojeda, D.V.M.
Programs:Cell & Developmental Biology
Neuroscience Graduate Program
Physiology & Pharmacology
Program in Molecular & Cellular Biosciences
Research Interests:neuroendocrinology of female sexual development. Neuron-glial interactions. Neurotrophic factors and ovarian development. Systems Biology. Genetics and Molecular Biology » Click here for more about Dr. Ojeda's research » PubMed Listing
Preceptor RotationsDr. Ojeda has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Ojeda has not indicated availability as a mentor at this time.
Summary of Current Research
Dr. Ojeda's main area of interest is the neuroendocrine control of female sexual development. His research efforts are focused on two principal topics: a) the role of glial-neuronal interactions and intercellular signaling in the regulation of the hypothalamic neuronal network that produces luteinizing hormone-releasing hormone, the neuropeptide that controls reproductive function, and b) the regulation of ovarian function by the peripheral nervous system and target-derived neurotrophic factors. Both fields of study employ a combination of physiological, biochemical, cellular, molecular and genetic techniques. Currently, Dr. Ojeda's research program focuses on the involvement of growth factors and transcriptional regulators in controlling both the maturation of the reproductive hypothalamus and differentiation of ovarian functions.
Mastronardi, G, GG Smiley, J Raber, T Kusakabe, A Kawagushi, V Matagne, A Dietzel, S Heger, AE Mungenast, R. Cabrera, S Kimura, and SR Ojeda. 2006. Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function. J Neurosci. 26:13167-13179.
Deng, V, V Matagne, F Banine, M Frerking, P Ohliger, S Budden, J Pevsner, L Sherman, and SR Ojeda. 2007. FXYD1 is a MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum Mol Genetics. 16:640-650.
Garcia-Rudaz, C, F Luna, V Tapia, B Kerr, L Colgin, F Galimi, GA Dissen, ND Rawlings, and SR Ojeda. 2007. Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis. Development. 134:945-957.
Heger, S, C Mastronardi, GA Dissen, A Lomniczi, R Cabrera, CL Roth, H Jung, F Galimi, W Sippell, and SR Ojeda. 2007. Enhanced at Puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis. J. Clin. Invest. 117:2145-2154.
1968 University of Chile, School of Veterinary Medicine, Valdivia, Chile. Doctor of Veterinary Medicine.
1972-1974 University of Texas Health Science Center at Dallas, Postdoctoral studies in Neuroendocrinology.
1965‑1966 Student Assistantship in Morphology,
1967 Student Assistantship in Physiology,
1968 Instructor in Physiology (Jan‑June),
1968‑1971 Assistant Professor of Physiology,
1972‑1974 Postdoctoral Fellow, Department of Physiology, Univ Tx Hlth Sci Ctr at Dallas, Southwestern
1974‑1978 Assistant Professor of Physiology,
1978‑1982 Associate Professor of Physiology,
1982-1987 Professor of Physiology, Univ Tx Hlth Sci Ctr at Dallas, Southwestern Medical School
1987-present Head, Neuroscience Div, ONPRC, OHSU, Beaverton, OR
Instructor T'ai Chi Ch'uan
Second Degree Black Belt Sheng Hun Kung Fu