Graduate Studies Faculty
James Maylie, Ph.D.
Programs:Neuroscience Graduate Program
Research Interests:Neuroscience, ion channel structure function, cellular » PubMed Listing
Preceptor RotationsDr. Maylie has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Maylie has not indicated availability as a mentor at this time.
Summary of Current Research
Dr. Maylie's laboratory studies the biophysics and modulation of native potassium channels in muscle and nerve and the structure-function and modulation of cloned potassium channels heterolougously expressed in Xenopus oocytes. Potassium channels contribute to repolarization of the action potential and modulate the excitability of neurons and muscle cells. Currently, we are analyzing mutations in the voltage-gated potassium channel responsible for the human disorder, episodic ataxia type 1 (EA1). The molecular basis of EA1 is being examined using whole cell and single channel recording and sub-cellular localization of EA1 subunits expressed in Xenopus oocytes and by the construction and electrophysiological characterization of transgenic mice harboring an EA1 allele. In addition in collaboration with Dr. John Adelman we have recently cloned the small conductance calcium-activated potassium channel (SK) that underlies the afterhyperpolarization in neuronal tissue and is ubiquitous in peripheral tissue including skeletal muscle from patients with myotonic muscular dystrophy. We are examining the modulation and regulation of SK channels in skeletal muscle, heart and neurons.
B.A. Math/Physics, Willamette University 1971
B.S. Electrical Engineering, Stanford University 1971
Ph.D. Oregon Health & Science University, 1977
1980-1981 Research Assistant Professor, Department of Physiology, University of Pennsylvania
1981-1986 Associate Research Scientist, Department of Physiology, Yale University