Graduate Studies Faculty

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James Maylie, Ph.D.

Professor, Obstetrics/Gynecology
Admin Unit: SOM-Obstetrics & Gynecology Department
Phone: 503-494-2106
Office: BH3030A
Mail Code: L458
Programs:
Neuroscience Graduate Program
Research Interests:
Neuroscience, ion channel structure function, cellular » PubMed Listing
Preceptor Rotations
Dr. Maylie has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Maylie has not indicated availability as a mentor at this time.
Profile

Summary of Current Research

Dr. Maylie's laboratory studies the biophysics and modulation of native potassium channels in muscle and nerve and the structure-function and modulation of cloned potassium channels heterolougously expressed in Xenopus oocytes. Potassium channels contribute to repolarization of the action potential and modulate the excitability of neurons and muscle cells. Currently, we are analyzing mutations in the voltage-gated potassium channel responsible for the human disorder, episodic ataxia type 1 (EA1). The molecular basis of EA1 is being examined using whole cell and single channel recording and sub-cellular localization of EA1 subunits expressed in Xenopus oocytes and by the construction and electrophysiological characterization of transgenic mice harboring an EA1 allele. In addition in collaboration with Dr. John Adelman we have recently cloned the small conductance calcium-activated potassium channel (SK) that underlies the afterhyperpolarization in neuronal tissue and is ubiquitous in peripheral tissue including skeletal muscle from patients with myotonic muscular dystrophy. We are examining the modulation and regulation of SK channels in skeletal muscle, heart and neurons.

Recent Publications

Education

B.A. Math/Physics, Willamette University 1971

B.S. Electrical Engineering, Stanford University 1971

Ph.D. Oregon Health & Science University, 1977

Previous Positions

1980-1981       Research Assistant Professor, Department of Physiology, University of Pennsylvania

1981-1986       Associate Research Scientist, Department of Physiology, Yale University

Non-Academic Interests