OHSU

Graduate Studies Faculty

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R. Stephen Lloyd, PhD

Professor
Senior Scientist
Admin Unit: SOM-Molecular & Medical Genetics Department
Phone: 503-494-9957
Lab Phone: 503-494-8638
Fax: 503-494-6831
Programs:
Molecular & Medical Genetics
Program in Molecular & Cellular Biosciences
Cancer Biology
Research Interests:
DNA repair; DNA replication; Mutagenesis; Metabolic Syndrome; Obesity and fatty liver; Skin cancer prevention » Click here for more about Dr. Lloyd's research » PubMed Listing
Preceptor Rotations
Dr. Lloyd has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Lloyd has not indicated availability as a mentor at this time.
Profile

Research Interests

DNA repair processes and high fidelity DNA replication represent the major mechanisms to maintain genomic stability. Our laboratory uses multi-disciplinary approaches to focus on:

Biography

Dr. R. Stephen Lloyd received his BS in Biology from Florida State University in 1975, majoring in marine pollution biology. His research interests turned to cancer chemotherapy and in 1979, he earned his Ph.D. in Molecular Biology from the University of Texas Graduate School of Biomedical Sciences in Houston, TX. After learning about mechanisms by which DNA can be damaged, he began his career in DNA repair as a postdoctoral fellow at Stanford University in the laboratory of Dr. Philip Hanawalt. Following two years at Stanford, he worked for two more years for a genetic engineering company, before joining the Biochemistry Department at Vanderbilt University in 1983. In his ten-year stay at Vanderbilt, Dr. Lloyd rose through the ranks to Full Professor, and his research focused on both DNA repair and molecular mutagenesis. He was then recruited to the Center for Molecular Science at the University of Texas Medical Branch in which the faculty exclusively specialized in DNA repair mechanisms. During his twelve years at UTMB, he also became the Director of two Centers in Environmental Toxicology. In August 2003, he, along with his wife, Dr. Amanda K. McCullough was recruited to join the CROET faculty at OHSU. Together they have both separate and joint research projects in the research areas described below.

Video

Links

Selected Publications

Fernandes PH, Kanuri M, Nechev LV, Harris TM, Lloyd RS. Related Articles, Links Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde. Environ Mol Mutagen. 45: 455-9, 2005.   Abstract

Minko IG, Kurtz AJ, Croteau DL, Van Houten B, Harris TM, Lloyd RS. Initiation of repair of DNA- polypeptide cross-links by the UvrABC nuclease. Biochemistry. 44: 3000-3009, 2005.   Abstract

Lloyd RS. Investigations of pyrimidine dimer glycosylases--a paradigm for DNA base excision repair enzymology. Mutat Res. 577: 77-91, 2005.   Abstract

Kanuri M, Nechev LV, Kiehna SE, Tamura PJ, Harris CM, Harris TM, Lloyd RS. Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks. DNA Repair (Amst). 4(12):1374-80, 2005.   Abstract

Sanchez AM, Kozekov ID, Harris TM, Lloyd RS. Formation of inter- and intrastrand imine type DNA-DNA cross-links through secondary reactions of aldehydic adducts. Chem Res Toxicol. 18(11):1683-90, 2005.   Abstract

Vartanian V, Lowell B, Minko IG, Wood TG, Ceci JD, George S, Ballinger SW, Corless CL, McCullough AK, Lloyd RS. The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci U S A. 103(6): 1864-9, 2006.   Abstract

Harbut, MB, Meador, M, Dodson, ML and Lloyd, RS. Modulation of the turnover of formamidopyrimidine DNA glycosylase. Biochem. 45(23): 7341-6, 2006.   Abstract

Fernandes, PH, Hackfield, LC, Kozekov, ID, Hodge, RP, Lloyd, RS. Synthesis and mutagenesis of the butadiene-derived N3 2'-deoxyuridine adducts. Chem Res Toxicol. 19(7): 968-76, 2006.   Abstract

Golan, G, Zharkov, DO, Grollman, AP, Dodson, ML, McCullough, AK, Lloyd, RS, Shoham, G. Structure of T4 pyrimidine dimer glycosylase in a reduced imine covalent complex with abasic site-containing DNA. J Molec Biol 362(2): 241-58, 2006.   Abstract