OHSU

Graduate Studies Faculty

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David Lewinsohn, MD PhD

Professor
Admin Unit: SOM-DOM Pulmonary and Critical Care Medicine
Phone: 503-721-1020
Lab Phone: 503-220-8262 x55138
Office: Cancer Research Center VA 103: F126
Mail Code: VA R&D 11
Programs:
Molecular Microbiology & Immunology
Program in Molecular & Cellular Biosciences
Research Interests:
Tuberculosis CD8 T Cells Immunology Antigen Processing and Presentation Human » PubMed Listing
Preceptor Rotations
Dr. Lewinsohn has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Lewinsohn has not indicated availability as a mentor at this time.
Profile

Lewinsohn Laboratory: CD8 T Cell Recognition of Intracellular Infection with Mtb

The Lewinsohn laboratory is focused on understanding the mechanisms by which human CD8+ T cells recognize cell infected with Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis. Areas of interest within the laboratory include:

1) Defining the repertoire of immunodominant antigens in Mtb.  Here, we have focused on antigens that are presented by classical HLA molecules (HLA-A, B, and C) as well as those presented by non-classical molecules such has HLA-E.

2) Defining the mechanisms by which Mtb-antigens can enter the HLA-I antigen processing pathway.  Because Mtb is an organisms normally found within the phagosome (traditionally a HLA-II processing compartment). We are currently focused on the role of the phagosome as a HLA-I processing compartment.

3) Defining the mechanisms by which innate T cells can recognize those cells infected with Mtb.  Here, early recognition of these cells might directly limit intracellular replication of Mtb, or might promote the development of an effective adaptive immune response.