Graduate Studies Faculty
David Lewinsohn, MD PhD
Programs:
Molecular Microbiology & ImmunologyProgram in Molecular & Cellular Biosciences
Research Interests:
Tuberculosis CD8 T Cells Immunology Antigen Processing and Presentation Human » PubMed ListingPreceptor Rotations
Dr. Lewinsohn has not indicated availability for preceptor rotations at this time.Faculty Mentorship
Dr. Lewinsohn has not indicated availability as a mentor at this time.Profile
Lewinsohn Laboratory: CD8 T Cell Recognition of Intracellular Infection with Mtb
The Lewinsohn laboratory is
focused on understanding the mechanisms by which human CD8+ T cells recognize
cell infected with Mycobacterium tuberculosis (Mtb), the bacteria responsible
for tuberculosis. Areas of interest within the laboratory include:
1) Defining
the repertoire of immunodominant antigens in Mtb. Here, we have focused on antigens that are
presented by classical HLA molecules (HLA-A, B, and C) as well as those
presented by non-classical molecules such has HLA-E.
2) Defining the mechanisms
by which Mtb-antigens can enter the HLA-I antigen processing pathway. Because Mtb is an organisms normally found
within the phagosome (traditionally a HLA-II processing compartment). We are
currently focused on the role of the phagosome as a HLA-I processing
compartment.
3) Defining the mechanisms by which innate T cells can recognize those cells infected with Mtb. Here, early recognition of these cells might directly limit intracellular replication of Mtb, or might promote the development of an effective adaptive immune response.
