Graduate Studies Faculty
Scott M. Landfear, PhD
Programs:Molecular Microbiology & Immunology
Program in Molecular & Cellular Biosciences
Research Interests:Molecular parasitology, membrane transport proteins, glucose transporters, purine transporters, Leishmania, African trypanosomes, screening for anti-parasitic drugs, protein trafficking, regulation of gene expression, post-transcriptional gene regulation, structure-function relationships in membrane proteins, electrophysiology, membrane protein structure. » Click here for more about Dr. Landfear's research » PubMed Listing
Preceptor RotationsDr. Landfear has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Landfear has not indicated availability as a mentor at this time.
My laboratory studies a variety of membrane transport proteins in parasitic protozoa of importance to human health such as Leishmania and the African trypanosomes. Overall we focus upon the structure, function, and biological activities of transporters that play especially important roles in the ability of the parasite to survive within both its insect vector and its human host. The research utilizes a multidisciplinary approach combining biochemistry, molecular biology, cell biology, genetics, and pharmacology. One approach is to clone genes for important transporters, generate null mutants deficient in these transporters, and examine the phenotypes of the mutant parasites. Another major direction involves examining the structure and function of individual permeases by site-directed mutagenesis followed by transport assays or by electrophysiological characterization of the permease. We are also interested in the trafficking of different permeases to distinct subcellular locations.
A detailed description of individual projects may be found at the Landfear laboratory web page at the following URL: http://www.ohsu.edu/microbiology/landfear.html