Graduate Studies Faculty
Kirsten J. Lampi, M.S., Ph.D.
Research Interests:cataracts, protein structure/ function, proteomics, high resolution mass spectrometry, multiangle laser light scattering, biophysical properties of lens proteins; molecular; hydrogen deuterium exchange with mass spectrometry » PubMed Listing
Preceptor RotationsDr. Lampi has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Lampi is not available as a mentor for 2016-2017.
Summary of Current Research: Structure/ function of the proteins in the lens of the eye. How modifications identified by proteomics during aging and cataracts lead to aggregation of these proteins called crystallins.
Takata, T, Oxford, JT, Demeler, B, Lampi, KJ. Deamidation destabilizes and triggers aggregation of a lens protein, bA3-crystallin. Prot. Sci. 17, 1565-75 (2008).
Takata, T, Woodbury, L.G. and Lampi, KJ. Deamidation alters interactions of b-Crystallins in hetero-oligomers. Mol. Vis. 15, 241-249 (2009).
Wilmarth, P., David, L.L. Lampi, K.J.Normal age-related changes- crystallin modifications, lens hardening. In: Darlene A. Dartt, editor. Encyclopedia of the Eye, Vol 3. Oxford: Academic Press; 2010. pp.161-166.
Michiel, M, Duprat, E, Skouri-Panet, F, Lampi, J.A., Tardieu, A, Lampi, KJ., Finet, S.Aggregation of deamidated bB2-crystallin and incomplete rescue by a-chaperone. Exp. Eye Res. 90, 688-98 (2010).
Takata, T., Smith, J.P., Arbogast, B., David, L.L., and Lampi K.J. Solvent accessibility of betaB2-crystallin and local structural changes due to deamidation at the dimer interface. Exp. Eye Res. 91:336-346, 2010 (PMID: 20639133).
Fort P.E., Lampi K.J., New focus on alpha-crystallins in retinal neurodegenerative diseases. Exp Eye Res. 2011 Feb;92(2):98-103. Epub 2010 Nov 27. Review.
Education: Post-doctoral Fellowship 1994, Kansas University Medical Center; Ph.D. 1993 OHSU, Biochemistry Molecular Biology; M.S. 1986, Colorado State University, Human Nutrition; B.A. 1984, Linfield College, Chemistry
Non-Academic Interests: Skiing and Hiking and Ethiopia