Graduate Studies Faculty
Kevin L. Grove, PhD
Research Interests:Development, obesity, diabetes, hypothalamus, metabolism, lactation, pregnancy, neuroendocrinology, liver, adipose tissue, molecular » Click here for more about Dr. Grove's research » PubMed Listing
Preceptor RotationsDr. Grove has not indicated availability for preceptor rotations at this time.
Faculty MentorshipDr. Grove has not indicated availability as a mentor at this time.
**Dr. Grove has accepted a new position in Seattle. He will continue with OHSU in a collaborative research projects but will no longer be taking OHSU graduate students.
Summary of Current Research
The Grove laboratory has several main areas of research focus, all of which have a general theme around the regulation of energy homeostasis. A major focus of our group is the investigation of the progression of metabolic disease, as well as therapeutic interventions. All of the studies in our group involve both rodents (rat and mouse) and nonhuman primates (NHP).
We are interested in the development of metabolic systems. More specifically, we are interested in the impact of maternal health and diet and postnatal nutrition on the development of these systems and the long-term impact on metabolic health. The primary focus of these studies is the development of hypothalamic neurocircuitry that controls food intake and sympathetic outflow. The damage to these systems during the critical period of development predisposes the offspring to numerous metabolic diseases later in life, including obesity, diabetes, and cardiovascular disease.
We are interested in the progression of metabolic disease induced by a high-fat diet. These studies primarily use adult rhesus macaques consuming a high-fat diet (HFD, 35% calories from fat diet). Similar to humans, these animals become obese, insulin resistant, develop hypertension, atherosclerosis, and eventually diabetes. A main focus of these studies is to determine the role of hyperlipidemia and proinflammatory cytokines in the development of the cardiovascular complications and diabetes. We have used this model to investigate the progression of metabolic disease in a critical primate model that develops the full spectrum of the disease. Furthermore, we have used this model to investigate several different classes of therapeutics, and are currently investigating the effects of dietary supplementation to mitigate the effects of the high fat diet. In addition, we are investigating the effects of utilizing a gastric bypass procedure on obese HFD animals.
- We are interested in the metabolic adaptations of pregnancy and lactation in the adult female. These studies also use rodent and nonhuman primate models. The primary focus of these studies has been on changes in insulin and leptin sensitivity that occur during these reproductive states. These studies investigate the neurocircuitry by which leptin and insulin may regulate the hypothalamic-gonadotropin axis. A secondary focus of these studies is the possible complications during pregnancy and lactation associated with obesity, diabetes, and consumption of a high fat diet.
Dr. Kevin L. Grove is the Division Chief and a Senior Scientist in the Division of Diabetes, Obesity, & Metabolism at the Oregon National Primate Research Center (ONPRC) at Oregon Health & Science University in Beaverton Oregon. Dr. Grove received his BSc in the Department of Animal Science at Washington State University in 1990, and his PhD in Neuroscience from the College of Veterinary Medicine at the same university in 1994. He did his postdoctoral work at the Institute of Clinical Research of Montreal. Dr. Grove returned to the Northwest to join the ONPRC in 1996. Dr. Grove currently serves as training faculty for 5 NIH-funded training grants: T32 NS007466: Multidisciplinary Training in Neuroscience (P. Barr-Gillespie, PI); T32 DK007680: Pre- and Postdoctoral Multidisciplinary Training in Neuroendocrinology (R. Goodman, PI); T32 HL094294: Training in Translational Science and Cardiovascular Medicine (K. Thornburg, PI); T32 HD007497: Training Grant in Pediatric Endocrinology (B. Boston, PI); and T32 DK007674: Training in Endocrinology, Diabetes, and Clinical Nutrition (R. Klein, PI). He has also provided training for the K12 Women’s Reproductive Health Research and K12 Building Interdisciplinary Careers in Women’s Health career development awards, and a Tartar Trust Fellowship award.