OHSU

Graduate Studies Faculty

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Allison Fryer, PhD

Professor
Admin Unit: SOM-DOM Pulmonary and Critical Care Medicine
Phone: 503 418 4010
Fax: 503 494 4352
Office: room 417 BRB
Mail Code: UHN67
Programs:
Neuroscience Graduate Program
Physiology & Pharmacology
Program in Molecular & Cellular Biosciences
Research Interests:
Asthma, neural plasticity, inflammation, allergic mechanisms, physiological responses in the lungs to ozone inhalation, viral infection and exposure to organophosphate pesticides. » PubMed Listing
Preceptor Rotations
Dr. Fryer has not indicated availability for preceptor rotations at this time.
Faculty Mentorship
Dr. Fryer is not available as a mentor for 2013-2014.
Profile

Research Interests
I have shown that airway hyperreactivity, that is similar to asthma, is accompanied by recruitment of eosinophil inflammatory cells to airway nerves.  These eosinophils are activated and release a preformed protein, eosinophil major basic protein, which binds to and blocks M2 muscarinic receptors on nerves.   M2 blockade increases neurotransmitter release and increases bronchoconstriction, similar to asthma.  My lab is examining what mechanisms underlie recruitment and activation of eosinophils at the autonomic nerves in the lungs.  We are also working to understand how exposure to viral infection, organophosphate pesticides, ozone, or allergens all induce loss of M2 receptor function in the nerves, and the role of eosinophils in the resulting airway hyperreactivity.

Collaborations include:
David Jacoby MD (Division of Pulmonary and Critical Care Medicine). Viral infections and biochemical interactions of inflammatory mediators with M2 muscarinic receptors. 


Current Graduate Students:  Sarah Wicher (joined 2011).  Recent Graduates: Kalmia Smith Buels (Phd 2012; postdoc at Harvard) Greg Scott (PhD 2011; now in MD program) Kirsten Blensly (PhD 2010) Postdoc NIEHS, NC. Norah Verbout (PhD 2008) postdoc at Harvard University; now running Biotecfirm OHSU), Mehdi Hazari (PhD 2005) Faculty at EPA.
 
Recent Publications

Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs.Verhein KC, Salituro FG, Ledeboer MW, Fryer AD, Jacoby DB. PLoS One. 2013 Sep 18;8(9):e75351.

Toll-like Receptor 7 Rapidly Relaxes Human Airways. Drake MG, Scott GD, Proskocil BJ, Fryer AD, Jacoby DB, Kaufman EH.Am J Respir Crit Care Med. 2013 Sep 15;188(6):664-72.

Toll-like receptor-2/6 and Toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs.Drake MG, Evans SE, Dickey BF, Fryer AD, Jacoby DB. Am J Respir Cell Mol Biol. 2013 Jun;48(6):790-6.

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 15;304(8):L519-29.

Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.Scott GD, Fryer AD, Jacoby DB. Am J Respir Cell Mol Biol. 2013 Jan;48(1):10-6. doi: 10.1165/rcmb.2012-0290MA. Epub 2012 Oct 25

Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma. Buels KS, Jacoby DB, Fryer AD. Br J Pharmacol. 2012 Mar;165(5):1501-14

Eosinophils increase neuron branching in human and murine skin and in vitro. Foster EL, Simpson EL, Fredrikson LJ, Lee JJ, Lee NA, Fryer AD, Jacoby DB. PLoS One. 2011;6(7):e22029

Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction.Nie Z, Scott GD, Weis PD, Itakura A, Fryer AD, Jacoby DB.Br J Pharmacol. 2011 Sep;164(2b):444-52

IFNγ Increases M2 Muscarinic Receptor Expression in Cultured Sympathetic Neurons. Grodzki AC, Ghogha A, Mangini L, Fryer AD, Lein PJ.Curr Neurobiol. 2011 Apr;2(1):23-29

Proskocil BJ, Bruun DA, Thompson CM, Fryer AD, Lein PJ.. Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms. PLoS One. 2010 May 10;5(5):e10562