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Issue 38 March 2009
The purpose of this newsletter is to share news and updates within the OHSU School of Medicine community and beyond. Please forward, copy or otherwise re-distribute this newsletter freely. Please also share with us (mcfallka@ohsu.edu) your news and ideas for future editions.

June 2010

Message from Dean Richardson: Mission Balance

Mark Richardson, Dean, OHSU School of Medicine

We learned this past month that a new survey published by the Annals of Internal Medicine recognized the OHSU School of Medicine as one of the best in the nation for training the most needed physicians.  

The study, titled "The Social Mission of Medical Education: Ranking the Schools," was designed to develop a metric to evaluate if medical schools are meeting society's health care goals. The authors defined this as producing an adequate number of primary care physicians, adequate distribution of physicians to underserved areas, and a sufficient number of minority physicians. OHSU was ranked #11 out of 133 US medical schools. That's a strong showing. 

There are fair questions about the underlying methodology of this new social mission metric – and some of those arguments have been made publically these past few weeks. By definition, such broadly-defined metrics will always be imperfect. However, what struck me when I read the results was the issue of mission balance. The study found that the level of support from the National Institutes of Health for research correlated inversely with output of primary care physicians, stating that schools with smaller "research portfolios" were more likely to meet the social mission of training needed physicians.  

Yet the OHSU School of Medicine is within the Top 25 recipients of research awards from NIH and still, we ranked #11 in the nation in this survey.

As OHSU has grown into a world-class leader in research over the last two decades, and as our clinical enterprise has also grown in size and stature, we have been able to balance that extraordinary success and growth with an enduring commitment to education – and not just to broadly defined educational goals – but a commitment to programs which meet the immediate social needs of Oregon and make a genuine difference in people's lives. One-third of all licensed Oregon physicians received all or part of their training at OHSU.

I credit the dedication and tenacity of vision of our faculty to achieving that mission balance. Far too frequently, I hear stories from incoming residents about how they were told, at the institutions where they earned their MD degrees, that the "best and the brightest don't pick primary care." This new study shows that many of the top-tier research medical schools are disproportionately graduating students interested in specialty care. Here, at OHSU, we have faculty leaders who steadfastly remind us all – through their dedication, accomplishments and actions – of our collective social obligation to primary care education and to balancing our missions. 

And while a moment of pride is well-deserved, we have much more to do. Access to basic health care is a challenge for many people and with reform, workforce issues will take on a new significance. We must remain committed to meeting the social mission of medical education and build on this success to do even more, while continuing to balance all our missions.

Thank you for everything you do for OHSU and Oregon.

Best regards,
  signature

Mark Richardson
Dean, OHSU School of Medicine
President, Faculty Practice Plan

Read the OHSU media release about this survey here.
counter in iweb

Alfons Krol named interim chair of Dermatology, Paul Flint to head search for new chair 

Dean Richardson has appointed Alfons L. Krol, MD, FRCPC, to the position of interim chair of the Department of Dermatology. This appointment is effective July 1, 2010. In making this appointment, Dean Richardson sought the input of dermatology faculty members; Dr. Krol emerged quickly as a consensus choice. "I am confident that Dr. Krol will be an effective and inspirational leader for the Department of Dermatology," said Dean Richardson. "I appreciate his willingness to step into this interim leadership role." Dr Krol

In March, Neil Swanson, MD, announced his intent to step down as chair after serving in this position for 15 years. Dr. Swanson decided to return to a more active role providing clinical care and education, and to refocus his considerable experience and expertise on his new role as Director of Clinical Operations in the OHSU Knight Cancer Institute.

Dr. Krol joined the OHSU School of Medicine faculty in September 2002 as a professor. Dr. Krol is also the director of Pediatric Dermatology at OHSU and Doernbecher Children's Hospital. He received his medical degree from the University of Alberta and completed his residency and fellowships at McGill University and the Montreal Children's Hospital. Previously, Dr. Krol was director of Pediatric Dermatology at the University of Alberta and the Stollery Children's Hospital, and also served as director of the Division of Dermatology at the University of Alberta.    

Paul Flint, MD, Professor and Chair, Department of Otolaryngology, Head and Neck Surgery, will lead the search for a new chair. The committee membership is:  

  • Rosalie C. Sears, PhD, Associate Professor, Department of Molecular and Medical Genetics
  • Jeffrey L. Koh, MD, Professor, Departments of Anesthesiology & Perioperative Medicine, and Pediatrics 
  • Scott Turner, MA, Associate Hospital Administrator, Pediatric Administration 
  • Charles D. Lopez, MD, PhD, Associate Professor, Departments of Medicine, and Cell & Developmental Biology 
  • Tomasz M. Beer, MD, Professor, Department of Medicine, Deputy Director, Knight Cancer Institute 
  • Phoebe Rich, MD, Oregon Dermatology and Research Center, and Adjunct Professor, Department of Dermatology

The department is engaged in a self-assessment process and the search committee will conduct interviews with department faculty, residents and staff to gain their perspective on the ideal attributes of the new leader. Outreach for the department chair position is underway. Advertisements for the chair position are running in relevant professional journals and letters are being sent to medical schools across the country. Additional person-to-person contacts will also be made.

"This is a very attractive leadership opportunity in a department comprised of exceptional faculty members, a history of strong clinical performance, nationally known educational programs and a robust research portfolio," said Dean Richardson. "The department is very important to OHSU, Oregon and to advancing the discipline of dermatology. I expect that this high priority search will attract a strong group of candidates."

Barney_Speight_6-28-10Oregon, OHSU and health care reform 

Barney Speight (Oregon Health Authority) and Dean Mark Richardson were the keynote speakers at the OHSU Annual Professional Board Staff meeting June 28. Dr Fields receives award 

Mr. Speight provided an overview of Oregon's ongoing health care reform efforts, including "taking apart" the Oregon Department of Human Services so that health aspects of the agency are in a single new agency. He also discussed the new all-payers, all-claims database which will support "Dartmouth Atlas style analyses of our Medicare, Medicaid and commercial payer spending across all Oregon communities." He concluded by thanking OHSU for its partnership in reform efforts. 

Dean Richardson discussed OHSU involvement in reform advocacy and the ongoing internal response to prepare for reform, noting that OHSU is ready for the system-focus of reform legislation because of prior hard work, including the integration of the Faculty Practice Plan and the School of Medicine. "This helped break down some of the internal barriers we have to system-wide change," he said. He also focused on the workforce aspects of the legislation, noting the need for new ways of organizing providers to demonstrate new delivery models.   

The OHSU Professional Board recognized outstanding contributions to OHSU with seven awards this month (some are jointly awarded). The award recipients were: Scott Fields, John Vetto, Windy Stevenson, Mark Reller, Jeffrey Koh, Cynthia Perez, Michele Noles, Kenneth Abbey, Arpana Naik, Charles Thomas and Carol Marquez.

The PowerPoint slides for both presentations and a listing of the awards are here (OHSU log-in required). 

Pictured: Barney Speight (left) speaking at the meeting and Scott Fields , MD, Professor, Department of Family Medicine, receiving the award for Innovation in New Models of Clinical Care from Brett Sheppard, MD, Chair, Professional Board.

Paper of the Month: Research shows how virus evades immune systems  

covermedThis month's featured paper was published in the April edition of the journal Science, and is titled: "Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus."In the paper, Klaus Früh, PhD, Louis Picker, MD, and colleagues in the OHSU Vaccine & Gene Therapy Institute and the Oregon National Primate Research Center report on how a herpes virus called cytomegalovirus (CMV) continues to reinfect human hosts despite the body's capacity to control the primary infection.  

Generally, the human body's immune system clears infections and also "remembers" them so that in the event of an encounter with the same or a similar virus, reinfection does not occur. But some viruses – such as CMV – outsmart the immune system. The OHSU team demonstrated that rhesus CMV can reinfect rhesus macaques (RM) that are highly immune against CMV because they already harbor a persistent infection by the same virus. This remarkable feat is possible because the incoming virus encodes proteins that inhibit major histocompatibility complex class I (MHC-I) antigen presentation, a process that normally alerts CD8+ "killer" T cells to an ongoing infection.

"We showed that CMV evades the immune alert systems by making genes that disrupt the MHC-I molecules' ability to communicate an ongoing infection to the T cells. InPickerandFruhphoto essence, CMV is able to cut off an infected cell's call for elimination. This allows CMV to overcome this critical immune barrier during reinfection," explained Dr. Früh.  

When these MHC-I inhibitory genes were deleted from CMV, the virus was unable to reinfect unless the CD8+ T cells were transiently removed from the animals. MHC-I interference was also dispensable when CMV-negative RM were infected for the first time. These findings demonstrate that the viral MHC-I inhibitory genes (called US2-11 glycoproteins) promote evasion of CD8+ T cells in vivo, thus explaining why CMV can so easily overcome pre-existing immune responses. 

CMV infects up to 80 percent of the U.S. population before age 40, reinfecting people again and again even though their immune systems strongly respond to it. For most people, CMV infection goes undetected and they do not become seriously ill. However, in vulnerable populations with weaker immune systems, such as infants, organ donor recipients and human immunodeficiency virus (HIV) patients, CMV poses a potentially deadly risk. 

This research suggests that it will be challenging to develop a vaccine to prevent CMV infection, although it might still be possible to limit CMV-associated symptoms and disease by vaccination. However, this research also explains previous results by Dr. Picker who showed that CMV can be used repeatedly as a viral vector to induce immune responses against other pathogens, such as the immunodeficiency virus. Thanks to its unique immune evasion strategies, CMV-based vectors are not limited by vector-specific immunity unlike most other viral vectors that are currently in development. 

This paper was reported on by several media outlets. You can read the Oregonian article here. Author listing: Scott G. Hansen, Colin J. Powers, Rebecca Richards, Abigail B. Ventura, Julia C. Ford, Don Siess, Michael K. Axthelm, Jay A. Nelson, Michael A. Jarvis, Louis J. Picker, Klaus Früh  

A list of all OHSU-authored papers published in the past two months is here.

Pictured: Drs. Picker (left) and Früh.

20,000 Oregonians enroll in Oregon POLST Registry   

The new Oregon Physician Orders for Life-Sustaining Treatment (POLST) Registry, which is operated by the OHSU Department of Emergency Medicine through a contract from the state of Oregon, went "live" statewide Dec. 3, 2009. Nicholas_Weltch_6Although having a POLST form is voluntary, state regulations now mandate that a health care professional who signs a POLST form send it to the new Registry unless the patient opts out. So far, about 20,000 Oregonians have made their information available to Emergency Medical Services (EMS) providers and physicians.

"This is a good outcome," said Terri Schmidt, MD, Professor, Department of Emergency Medicine, and Director, Oregon POLST Registry. "In my decades as an emergency medicine physician, I know how quickly an unexpected event can become a medical tragedy for someone with a long-standing illness. The Registry is a tool that ensures professionals have rapid access to a patient's wishes." 

The original bright pink POLST document remains the primary method of indicating one's preferences for emergency care. At OHSU, a copy is included in a patient's electronic health record (EHR), but not all systems and providers use an EHR, or the same EHR. Furthermore, the paper POLST form frequently is not immediately available to EMS personnel in a time of crisis. Now, copies of POLST forms are entered into a secure electronic database (the Registry) that allows EMS responders to call a phone number and – within about 80 seconds – determine whether the patient has a POLST form on record. 

"The POLST Program came about as a way of ensuring that people with advanced illness or frailty receive the treatments they want and avoid those they do not want," said Susan Tolle, MD, Cornelia Hayes Stevens Chair, Professor, Department of Medicine, and Director, OHSU Center for Ethics in Health Care. "The Registry provides a backup system for quickly relaying a patient's wishes as medical orders to the health care professionals who need it, when they need it."

As of May 31, there are 17,626 active, searchable forms; 2,040 archived forms; and 2,437 forms that are not Registry-ready, meaning there is missing or illegible information. Steps to further enhance the POLST Registry will be taken later this summer, when Dr. Schmidt and her colleagues begin contacting EMS providers and patients or the patients' family members who have used the Registry to get feedback on their experience.

OHSU's Center for Ethics provides education about POLST to patients and health care professionals, and has distributed over one million forms in Oregon since 1995. However, there has been no way to track the number of completed forms nor has there been a centralized repository for them. Now, the Registry provides an unprecedented opportunity for leaders of the program. "For the first time, we will know how many POLST forms are out there," said Dr. Schmidt. "We'll know what choices Oregonians are making." 

The POLST hotline for EMS is staffed 24/7 by the OHSU Emergency Communication Center in the Department of Emergency Medicine. The Registry has received a total of 151 calls, with a match rate of about 14 percent. Dr. Schmidt said she expects the match rate to increase as the Registry receives more entries. 

Thirty-three states have either implemented or are developing a POLST program similar to the model pioneered in Oregon. "The POLST program, developed at the Center for Ethics at OHSU, is a model for the nation," said Dean Richardson. "It allows individuals to make choices about care they receive in advance of an emergency, when those decisions can be carefully and completely thought through." 

Pictured: Nicholas Weltch, Emergency Transport Coordinator, responds to calls, including inquiries about patients in the POLST Registry, in OHSU's Emergency Communication Center. 

Do you feel like an imposter? Wellness program helps residents, faculty manage stress

Maybe it's the 80-hour week residents put in, maybe the feelings of being an imposter that afflicts many of them, maybe the stress, or perhaps just the weight of feeling, after four long years of medical school, Wellnessfacultythat they're back to square one. Whatever it is, it happens to nearly all new residents, and it happens pretty much like clockwork midway through their first year. They begin to question their choice of careers. The altruism that drew most of them to the profession begins to compete with a creeping sense of cynicism. They find themselves feeling irritable, undervalued, and under-rewarded. The personal meaning in the practice of medicine gets lost in the overwhelming fatigue.

It's a trajectory that long has troubled Donald Girard, MD, OHSU's Associate Dean for Graduate Medical Education. "We've done a lot of studies over the years," said Dr. Girard, "and have consistently found that most residents, not all, but most, began struggling sometime around the middle of their first year. It's not the rain, it turns out, and it's not even necessarily the hours." Australian residents, who are limited to 55 hours, encounter the same problem."

"The suicide of an OHSU resident was the 'sentinel event' that ultimately impelled OHSU to establish the Resident Wellness Program," said Mary Moffit, PhD, Assistant Professor, Department of Psychiatry, who joined Dr. Girard, and the Department of Psychiatry's Sydney Ey, PhD, Associate Professor, and Mark Kinzie, MD, PhD, Assistant Professor, to develop and staff the Resident Wellness Program. The program is rooted in the theory that staying well is at least as important for residents as learning to help others get well. The six year old pioneering program has proven so successful that in July 2008 it was opened up to faculty. 

"Physicians are not high utilizers of health care services," said Dr. Moffit. "Often, they don't have primary care docs, they don't go for wellness checkups, and they don't go to counseling." Yet, said Dr. Ey, "at least 50 percent of physicians in practice report that they know a colleague who has been, or is, burned out." The program is confidential and there is no cost. The Oregon Board of Medical Examiners supports this program and, unless a physician is impaired by an illness – is practicing medicine impaired – no information is disclosed to the Board.

Read the full story here.

Pictured (left to right): Drs. Ey, Moffit and Kinzie.

To schedule a meeting with the Resident and Faculty Wellness, Program  contact Dr. Moffit: moffitm@ohsu.edu or 494-1208. If urgent, call 503 330-7880.   

From the Archives: Howard Mason visits Japan   

A terrible photograph. Grainy, blurry, overexposed. One of two (and the better of two) snapshots of people in a scrapbook labeled "Japan 1977." Seated at left is OHSU biochemist Howard S. Mason, PhD, mason_japan1977notebook_079meeting with Japanese colleagues at the Research Institute for Food Science in Kyoto, on April 13, 1977. 

Dr. Mason had been collaborating with Japanese scientists for decades by the time of this trip, and would continue to do so for the remainder of his career. In 1988, Dr. Mason was the first Oregonian to receive the Order of the Rising Sun, Third Class, for his work in fostering scientific exchange between the United States and Japan. Of his experiences working with the Japanese, Dr. Mason wrote: "I [had] encountered the idea that it is no harder to find and work on important questions than trivial ones, and I learned the difference between them in terms of the generalizations and principles that could emanate from any set of experiments. However, I only did one critical experiment in my life – the discovery of biochemical oxygenation, or rather, of biological oxygen transfer. At any rate, that is what I brought to my Japanese colleagues, although most of them probably never knew what hit them…" 

This scrapbook and others like it were put together by Dr. Mason during his long career at OHSU, which spanned more than thirty years. Books, research, and correspondence have been deposited in the OHSU archives so that historians can determine what else Dr. Mason brought to his colleagues, both at home and abroad.

Contributed by Sara Piasecki, Head, OHSU Historical Collections & Archives.

A tale of mentoring inspired by the 1960s NASA "Race to the Moon" and a 25-year quest GrandyandNaidu

David K. Grandy, PhD, Professor, Department of Physiology & Pharmacology, has mentored many high school science students in his 25 years as a research scientist in the OHSU School of Medicine. But Yamini Naidu, his latest charge, is in a class by herself. The diminutive ninth grade student – who turned 15 in January and barely reaches five feet on her tiptoes – got turned on to science in middle school after winning awards at several school science fairs.

She discovered that she had a true passion for science and decided to search for a place to get practical professional guidance on how "real" scientific research is done. She e-mailed a number of investigators, but Dr. Grandy, Professor, Department of Physiology and Pharmacology, was the only one who followed up with her and encouraged her to pursue her interest. "I was impressed by her e-mail," he said.

"My laboratory was going through a transition and I had room for her and an ideal project." He recalled his own youth back in Cleveland, Ohio, where he had the opportunity to work with scientists at NASA's Lewis Research Center in the 1960s during the height of the "Race to the Moon." 

"That experience not only gave me confidence in myself but seeing how professional scientists work was really transforming. Having benefited from that kind of special opportunity, I've always felt the best way to repay the generosity of my NASA mentors is to share my passion for basic research and discovery with those who are really motivated."

Dr. Grandy's generosity would prove to be mutually beneficial. Yamini joined a quest Dr. Grandy and his team have been on for 25 years, to design new drugs that offer promise in treating debilitating mental conditions, one of them being methamphetamine addiction. Read the full story here.

The ripple effect: expanding on-campus faculty mentoring  

The School of Medicine/OCTRI Lead Mentors program is now accepting applications for 2010-11 – deadline July 15. Don't delay! Apply now!   Montage 6-28-10 copy

Supporting on-campus mentoring and faculty development is an investment in faculty success. The School of Medicine/OCTRI Mentoring Program is designed to help individual faculty members get the career development assistance they need, provide resources to departments to enhance the quality and scope of their mentoring programs, and – through the ripple effect – expand the available pool of mentors within the institution. 

The program has proven to be a good investment even in its first year. As the program embarks on its second year, faculty input is forming the basis of program upgrades to the two major program components.

The first – the individualized, self-directed component – is a series of seminars and workshops that provide an overview of key career development topics. This past year, this program component:  

  • Launched a comprehensive faculty development and mentoring website.
  • Conducted seven one-hour Career Perspectives sessions and six two-hour Mentor Skills Workshops September through May.
  • Hosted more than 200 faculty, students and staff who attended at least one of these events, with faculty from 17 of 19 clinical departments and four of seven basic science departments registered for at least one event. The majority of attendees (40 percent to 100 percent per session) were women.
  • Received favorable quality ratings for the majority of sessions. 

The second component – the Lead Mentors Program:  

  • Enrolled an inaugural cohort of 13 faculty as Lead Mentors.
  • Conducted six in-depth sessions during six months covering topics such as "coaching through listening," "mentoring across differences," and "managing difficult conversations."
  • Received an overall program rating of 4.0 on a five-point scale. 

Based on faculty feedback, both program components will continue and will be enhanced by bringing national speakers to campus, providing more sessions specifically for basic science faculty, and – for the Lead Mentors Program – incorporating an explicit description of a mentoring project that will be undertaken in the faculty member's department.  

Join the ripple effect: apply now to be a Lead Mentor and learn more about this initiative.  

Pictured: Lead Mentors discuss the first year's program at a debrief lunch with Dean Richardson.

Breaking barriers: ARRA $4.38 million award supports integrated core research facilities   

Harrington_Searles_StreeterNext year, OHSU investigators will be able to take advantage of new core research facilities thanks to a $4.38 million award from the National Center for Research Resources. This award, which was funded through the American Recovery and Reinvestment Act, will support the renovation of about 5,400 square feet in Richard Jones Hall and will integrate facilities for flow cytometry and genomic analysis. The goal of this renovation initiative is to improve campus resources for molecular and cellular characterization – and to reduce barriers for OHSU scientists. 

This project consolidates flow cytometry technologies available within the Flow Cytometry Shared Resource. The renovation will also create shared space for the Massively Parallel Sequencing Shared Resource that, together with the Microarray Shared Resource, will make up the new OHSU Integrated Genomics Laboratory. After the renovation, these two revamped core facilities – the Flow Cytometry Shared Resource and the Integrated Genomics Laboratory – will occupy contiguous space, allowing for administrative efficiencies and closer scientific collaboration. 

Headed by Phil Streeter, PhD, Associate Professor, Department of Medicine, OHSU's Flow Cytometry Shared Resource was established in 1996. It provides consultation, training and teaching, technical expertise, and technical services. Instrumentation includes analytical flow cytometers and cell sorters. Currently, however, its resources are located in part on the OHSU campus and in part at the Portland VA Medical Center. 

"Consolidation of the flow cytometry technologies will make it easier to use the facilities and the new location in Richard Jones Hall will be closer to the vast majority of investigators," said Dr. Streeter. "We are excited about this opportunity to enhance flow cytometry services for our investigators."

The award also provides momentum for the new Integrated Genomics Laboratory, with Chris Harrington, PhD, Assistant Professor, Department of Molecular & Medical Genetics, and Senior Staff Scientist, as the Director, and Bob Searles, PhD, Senior Staff Scientist, as the Associate Director. Structural and functional genomic analysis resources at OHSU currently include a Gene Microarray Shared Resource and a Massively Parallel Sequencing Shared Resource. The Gene Microarray Shared Resource operates two microarray technology platforms – the Affymetrix GeneChip System and the Illumina BeadArray System. Last year, OHSU was awarded an Illumina Next-generation Sequencer, thanks to the generosity of the M.J. Murdock Charitable Trust. This instrument, as well as the increased sample throughput and data management resources that accompany these technologies, requires expanded and renovated space. The renovation will relocate all these genomic technologies from the Center for Health & Healing to Richard Jones Hall, now newly adjacent to the Flow Cytometry Shared Resource.

"Besides better space and more convenient locations, we are all excited about the potential of the co-located facilities to enhance scientific collaborations," said Dr. Harrington. The proximity of these facilities will increase both the quality and efficiency of services provided to investigators. Bringing these resources together will enable co-development of methods and technologies to minimize the number of cells required for array or sequencing assays. Further, rapidly handing off purified cells from the Flow Cytometry Shared Resource to the Genomics Laboratory will minimize the chances of changes in gene expression profiles and will enhance the potential to isolate intact and high-quality RNA and DNA from smaller numbers of cells. 

The core renovation project is currently in the design completion phase. Construction is expected to begin later this year, and facilities will be completed in 2011. OHSU also received a $4 million award to construct new facilities at the Oregon National Primate Research Center. This project is nearing completion of its design phase as well.

Pictured (left to right): Drs. Harrington, Searles and Streeter.

Pill Hill Pirates take the title!  Physician Assistant program's kickball fundraiser for Wallace Medical Concern Kickball096-2

The OHSU Physician Assistant Class of 2011 recently put on several fundraising events to benefit Wallace Medical Concern, raising $2,000 for the local clinic. With locations in Gresham and Portland, the Wallace Medical Concern provides neighborhood-based health care services and assistance for Portland's low-income and uninsured residents. 

During the Oregon Society of Physician Assistants' Spring Medical Update in Portland, students held a raffle with items such as Beavers baseball game tickets, handmade jewelry and a local restaurant gift certificate. With the help of CME attendees, the group was able to bring in $500 toward their goal. An additional $600 was raised at the fall CME conference, also to benefit Wallace Medical Concern.

The following week, the class hosted the third annual OHSU Kickball Tournament, a tradition begun by OHSU's PA Class of 2010. More than 150 people competing on 10 teams representing the PA, dental, medical, nursing, RT, and RA schools raised $1,000. The Med 11 Team "Pill Hill Pirates" took the title, with the PA 11 team "Kick in the Grass," finishing a close second. On May 11, representatives from the Wallace Medical Concern visited the Marquam Hill campus to accept the $2,000 donation from the PA class.

Honors, announcements and appointments

Dennis Bourdette receives UC Davis Distinguished Alumnus Award  

Bourdette and CP Newsletter sizedDennis Bourdette, MD, Roy and Eulalia Swank Family Research Professor, and Chair, Department of Neurology, received the 2010 Distinguished Alumnus Award from the University of California Davis School of Medicine for outstanding achievements in medicine.  

"We are proud to honor Dr. Bourdette with this award," said Claire Pomeroy, MD, MBA, Vice Chancellor and Dean of the UC Davis School of Medicine. "As founder and director of the OHSU Multiple Sclerosis Center, he is widely recognized as a national expert on the clinical care of multiple sclerosis, with patients referred to him by neurologists from throughout the Pacific Northwest."  

Dr. Bourdette's research focuses on lipoic acid – an anti-oxidant that he has proved to be effective in an animal model of multiple sclerosis. In collaboration with other researchers, he also discovered that inactivation of a mitochondrial protein, cyclophilin D, is neuroprotective in experimental autoimmune encephalomyelitis (EAE). This discovery has served as the basis for a patent application and the emerging development of a novel therapy for multiple sclerosis. 

"I am deeply honored to receive this award," said Dr. Bourdette. "I had great teachers at UC Davis School of Medicine who taught me that my first duty as a physician was to serve my patients. I will always be grateful to them and UC Davis." 

Pictured: Dean Claire Pomeroy presents the award to Dr. Bourdette.

David Ellison appointed to the Chair of ABIM’s Subspecialty Board on Nephrology

d-ellisonDavid Ellison, MD, Professor, Departments of Medicine and Physiology & Pharmacology, has been named Chair of the American Board of Internal Medicine’s (ABIM) Subspecialty Board on Nephrology. As such, he becomes the subspecialty board’s representative to ABIM’s Board of Directors. Dr. Ellison has been a member of the Subspecialty Board on Nephrology since 2000. ABIM sets the standards and certifies physicians practicing in internal medicine and its subspecialties who possess the knowledge, skills and attitudes required to provide high quality care.

“David juggles the roles of teacher, innovator and clinician capably, balancing the demands of each while utilizing his myriad roles to inform all of his work. As a member of the subspecialty board he will now chair, he will continually bring his experience in nephrology in creating certification and maintenance of certification programs that are current and relevant to what physicians are doing in practice,” said Christine Cassel, MD, ABIM's President and CEO.

Four MD/PhD candidates win coveted NRSA "F" awards  

Four OHSU MD/PhD candidates have been awarded coveted Ruth L. Kirschstein National Research Service (NRSA) fellowships by the National Institutes of Health. The awards – known as "F" awards based on the coding NIH assigns them – provide stipends to support each student's research and pay for tuition and fees. The award recipients are Daniel Cleary, Art Riddle, Kimmy Su and Rebecca Williams. These new awardees join five other recipients of this prestigious grant among the current MD/PhD students: Ted Braun, Jeff Chen, Aaron Grossberg, Emily Pratt and Chris Severn. 

Read more about the students, their graduate studies mentors and their research here.

Chad R Burk Med student Chad Burk selected for the HHMI-NIH Medical Research Scholars program 

Chad Burk, third year med student, joins 116 medical, dental, and veterinary students from 47 schools across the country to spend a year in a lab doing hands-on research as part of the prestigious Howard Hughes Medical Institute-National Institutes of Health Medical Research Scholars program that seeks to strengthen and expand the pool of medically-trained researchers. The HHMI program is typically a one-year research program at the National Institutes of Health (NIH) in Bethesda, MD.. 

Students are housed on the NIH campus in the HHMI owned Cloister. Chad lists his research interests as immunology, biomarker discovery, theranostic nanomedicine and molecular imaging, and targeted drug delivery and gene therapy.  As an undergraduate, he was a Bioengineering major with a Biotechnology emphasis at University of California, San Diego. 

OCTRI Announces 2010 Student Research Scholarships 

The Oregon Clinical and Translational Research Institute's commitment to clinical and translational research includes support for the next generation of researchers. Each year, OCTRI awards OHSU students scholarships that allow them to design and participate in research projects under the guidance of a faculty mentor. The awards are part of the Oregon Students Learn and Experience Research (OSLER) program, which is supported by an NIH TL1 training award. OCTRI also provides direct funding to support six additional students who conduct short-term studies over the summer.

This year's awards include four MD/MPH students, seven MD students, one doctoral candidate in Biomedical Engineering, and four students from the School of Dentistry. 

View the 2010 Student Trainees and Research Scholars.

Frederick Keller receives International Cooperation Award 

Frederick S. Keller, MD, Chair, Department of Diagnostic Radiology, and Director, Dotter Interventional Institute, received the International Cooperation Award for 2010 from the Chinese Society of Interventional Radiology (CSIR) for having made important contributions to China's interventional radiology. CSIR is China's largest educational and scientific society dedicated to interventional radiologists. 

The society represents physicians and scientists while promoting the high quality practice of interventional radiology and demonstrating the latest information of basic and clinical research pertinent to the field. Dr. Keller will be honored at the 9th Scientific Meeting of Chinese Society of Interventional Radiology held Sept. 8-12, 2010, in Guangzhou, China.

Joe Gilhooly receives Robert S. Holm Leadership Award for Pediatric Program Directors  

Joe Gilhooly, MD, Professor, Department of Pediatrics, received the Robert S. Holm Leadership Award at the 2010 Association of Pediatric Program Directors meeting in Chicago, IL. This award is a national recognition for the one current or former Pediatric Residency Program Director who has made extraordinary contributions in leadership and for the support of other pediatric program directors as a mentor, advisor and role model. Dr. Gilhooly led the pediatric residency program for 15 years during which time the program became extremely competitive and had outstanding test score outcomes. "The Doernbecher Children's Hospital residency program is now one of the most competitive in the country thanks in large part to Dr. Gilhooly's leadership," said Stacy Nicholson, MD, Professor and Chair, Department of Pediatrics.  

Patricia Hurn receives 2010 Faculty Senate Award for Collaboration  

The 2010 OHSU Faculty Senate Award for Collaboration was awarded to Patricia Hurn, PhD, Associate Dean for Faculty Development and Faculty Affairs, and Professor and Vice Chair for Research, Department of Anesthesiology & Perioperative Medicine. Dr. Hurn holds joint appointments in the Department of Physiology and Pharmacology and the Department of Neurology and is also Director of the OHSU Research Center for Gender-Based Medicine.

In her letter of nomination, Sharon Anderson, MD, Professor, Department of Medicine, Vice Chair for Veterans' Affairs and Chief of Medical Service, Portland VA Medical Center, wrote: "Dr. Hurn sets the standard for collaboration among her colleagues within our department and across our campus. As an internationally recognized stroke expert, she has used her collaborative skills to advance the research careers of new investigators as well as more seasoned investigators. Read more here.

Maria Fleseriu promoted to FACE Fellow  

Maria Fleseriu, MD, Assistant Professor, Departments of Medicine and Neurological Surgery, was recently promoted to Fellow of the American College of Endocrinology (FACE) in recognition of her high standards of excellence and achievement in endocrinology and quality of care given to her patients. According to the American College of Endocrinology (ACE), promotion is based on an expanding scientific reputation and contributions to the ACE.   

Lalena M. Yarris honored with CORD Faculty Teaching Award  

Lalena M. Yarris, MD, Assistant Professor, Department of Emergency Medicine, is the 2010 recipient of the Council of Emergency Medicine Residency Directors (CORD) Faculty Teaching Award. Dr. Yarris received the award in June during the CORD Business Meeting in Phoenix. Dr. Yarris completed her residency at OHSU after which she became the Assistant Residency Program Director. One year later, she became Co-Director of the EM Education Research Fellowship. 

Her experiences as a resident at OHSU inform her teaching and Dr. Yarris consistently receives outstanding evaluations for bedside teaching, didactic lectures, small group instruction and student mentoring. Among other accomplishments, Dr. Yarris founded the Emergency Medicine Education Research Group (EMERGe) to promote collaborative education research among academic emergency physicians, and heads CORD's End-of-Shift Feedback Project. 

Ryan Palmer interviewed about use of technology in medical education  

Ryan Palmer, MFA, was featured in an article in the journal of the American Academy of Family Physicians discussing web-based learning. Ryan is Administrative Director for the School of Medicine "Principles of Clinical Medicine" course. He is also the administrator for the Curriculum Committee and assists with distance learning for the OHSU Rural Scholars Program. He is currently pursuing his Doctorate of Education in Educational Leadership: Postsecondary Education at Portland State University. Ryan told AAFP News Now he is particularly excited about the potential of Google Wave, a Web 2.0 manifestation that he called a combination of real-time chat, wiki, blog and content repository.  

Read the article here.

Welcome New Faculty  

A warm welcome to our newest faculty members, listed alphabetically: 

  • Dayana Rodriguez-Contreras, PhD, Research Assistant Professor, Department of Molecular Microbiology & Immunology   
  • Joseph T. Ichter, DrPh, MHA, Assistant Professor, Department of Family Medicine   
  • Kari Kohrs, MPH, RD, Instructor, Department of Medicine   
  • Frank M. Warren, MD, Assistant Professor, Department of Otolaryngology, Head & Neck Surgery  
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