OHSU

Research Collaboration Publishes

Sulphoraphane Study

The lab of Agnieszka Balkowiec, M.D., Ph.D., associate professor of integrative biosciences, has contributed its expertise to a project led by Fawzy Elbarbry,Ph.D., associate professor of pharmacy at Pacific University, resulting in an important new discovery that has implications for the prevention and treatment of hypertension, which affects about one in three adults in the United States.

The study was recently published in ISRN Pharmacology, a peer-reviewed, open-access journal: http://www.hindawi.com/journals/isrn.pharmacology/2014/683508/

Using spontaneously hypertensive rats, the researchers demonstrated blood pressure-lowering benefits of sulforaphane, the main active ingredient of cruciferous vegetables, such as cauliflower, bok choy, and broccoli. The current study is the first to link sulforaphane with a specific metabolic pathway that, ultimately, leads to a significant decrease in blood pressure. 

“While the effective concentration of sulforaphane used in our study significantly exceeded the concentration that is possible to achieve from an average daily consumption of cruciferous vegetables, a beneficial cumulative effect of a diet rich in these vegetables is likely,” said Dr. Balkowiec.

Anke Vermehren-Schmaedick, Ph.D., research associate, department of biomedical engineering, also contributed to the project.