John R. Smith

John R. Smith John R. Smith, Ph.D. (Oregon State U, 1976)


Research Interests

My current research interests involve analgesic therapy following dental treatment. The main goal of the research is to determine the optimal drug regimens that will maintain adequate analgesia and minimize adverse side effects. These studies are clinical in nature and rely upon visual and verbal analogue scales to sample the subjective aspects of analgesic treatment. Questions concerning when to start treatment, how long to maintain treatment, frequency of dosing, optimal dosage, are among the objectives of these studies.

In the past my lab has also pursued more basic research into the additive toxicity of mercury and nitrous oxide - two agents commonly encountered in the dental office atmosphere. I have also collaborated with Walter Gabler, DDS, Ph.D., in studies directed toward understanding the protective effects of the tetracycline family of antibiotics in situations of ischemia/reperfusion injury. Although I am not currently doing active research in these two areas, I nevertheless still remain very interested in these topics.

In addition to my research interests I also have substantial time commitments in the areas of teaching and continuing education. I am the Director of Continuing Dental Education at OHSU and I am the course director for all pharmacology courses offered to dental residents and dental students.

Representative Publications

John R. Smith and Walter L. Gabler, Protective effects of doxycycline in mesenteric ischemia and reperfusion. Research Communications in Molecular Pathology and Pharmacology, 88(3):303-315 (1995).

Patricia Tucker, John Smith, and Donald Adams, A comparison of two regimens for the control of postoperative periodontal discomfort. Journal of Periodontology, 67:125-129 (1996).

Kenneth Reed, John Smith, Tryggve Lie, and Donald Adams, A pilot study comparing ketoprofen and acetaminophen with hydrocodone for the relief of post-operative discomfort. Anesthesia Progress, 44:49-54 (1997).