Michael J. Meredith, Ph.D.
Research Interests: Molecular Toxicology and Carcinogenesis
Research in my laboratory is addressing several aspects of glutathione (GSH) and sulfur amino acid metabolism relating to problems of molecular pathology. We have three ongoing projects:
- The increasing role of redox cycling and oxidant challenge in the pathology of Alzheimer's disease implies the participation of glutathioneas a protective mechanism. Our studies with control and Alzheimer's disease patient lymphoblast cell lines have shown an increased level ofoxidant stress and elevation of glutathione synthetic capacity in Alzheimer's disease patients. Current studies are examining the source of the oxidant challenge and the regulatory mechanisms involved in cellular response to Alzheimer's disease.
- The role of spirocheetes in periodontal disease is being studied during the healthy to disease transition phase. Quatitation of bacterial populations by QPCR allows us to follow changing bacterial ecology and make correlations with clinical observations in this prospective epidemiological study.
National Institutes of Health
Bakin AV, Stourman NV, Sekhar KR, Rinehart C, Yan X, Meredith MJ, Arteaga CL, Freeman ML. Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.Free Radic Biol Med. 2005 Feb 1;38(3):375-87.
Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML. NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.Cancer Res. 2003 Sep 1;63(17):5636-45
Meredith MJ. Herbal nutriceuticals: a primer for dentists and dental hygienists.J Contemp Dent Pract. 2001 May 15;2(2):1-24. Review.
Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML. Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.Free Radic Biol Med. 2002 Apr 1;32(7):650-62. Erratum in: Free Radic Biol Med 2002 Jul 31;33(1):149.
Yatvin MB, Li W, Meredith MJ, Shenoy MA. Improved uptake and retention of lipophilic prodrug to improve treatment of HIV.Adv Drug Deliv Rev. 1999 Oct 18;39(1-3):165-182.
Sekhar KR, Soltaninassab SR, Borrelli MJ, Xu ZQ, Meredith MJ, Domann FE, Freeman ML. Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase.Biochem Biophys Res Commun. 2000 Apr 2;270(1):311-7.