The OHSU Library and the Department of Medical Informatics &Clinical Epidemiology (DMICE) have been awarded two grants through the NIH Big Data to Knowledge (BD2K) initiative, with the goal of improving health research by training students and researchers to better utilize and generate knowledge from large biomedical datasets. One project is to develop skills courses, with the goal of training students in key issues of big data analysis: problem description, data set discovery, preparation and creation of data sets, and implementation of advanced techniques. The courses will be offered in a hybrid learning environment, part online and partially through in-person intensive courses. In addition to the skills courses, our group is developing Open Educational Resources, in the form of online materials that are available here, that are freely available to educators and students. The ultimate goal is to train data scientists and improve knowledge discovery.