GH Research
- Building on our 2008 NIH Fogarty Framework grant award titled, "Global Health in Changing Environments," to inspire enquiry and discovery by embedding research in global clinical and educational activities of students and faculty
- Stimulating and coordinating collaborative grant-writing and research projects
- Facilitating global health projects by appointing a global health representative to the Institutional Review Board (IRB)
- Connecting researchers with the NIH Fogarty International Center
- Hosting global health research symposia and lecture series
- Facilitating and providing joint resources to support collaborative global health research projects
Recent OHSU GHC publications
Recent OHSU GHC publications resulting from research on diseases outlined in the Poison That Waits documentary. View BBC documentary, opposite.
- Kisby, G.E., Fry, R.C., Lasarev, M.R., Bammler, T.K., Beyer, R.P., Churchwell, M., Doerge D.R., Meira, L.B., Palmer, V.S., Ramos-Crawford, A-L., Ren, X, Sullivan, R.C., Kavanagh, T.J., Samson, L.D., Zarbl, H., Spencer, P.S. The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner. PLoS One 6(6):e20911. Epub 2011 Jun 23, 2011.
- Kisby, G.E., Spencer, P.S. Is neurodegenerative disease a long-latency response to early-life genotoxin exposure? Int J Environ Res Public Health. 2011 Oct;8(10):3889-921. Epub 2011 Sep 29.
- Kisby, G.E., Palmer, V., Lasarev, M., Fry, R., Iordanov, M., Magun, E., Samson, L. Spencer, P.S. Does the cycad genotoxin MAM implicated in Guam ALS-PDC induce disease-relevant changes in mouse brain that includes olfaction? Communicative & Integrative Biology (in press).
The International Compilation of Human Research Standards
The International Compilation of Human Research Standards is a listing of over 1,000 laws, regulations, and guidelines on human subjects protections in over 100 countries and from several international organizations. Many of the listings embed hyperlinks to the source document. This Compilation was developed for use by researchers, IRBs/Research Ethics Committees, sponsors, and others who are involved in human subjects research around the world.
The 2012 edition features new sections that enumerate the laws, regulations, and/or guidelines pertaining to Research Injury, for which 53 standards were identified. Two new countries are included in the 2012 Edition: Barbados and Haiti. As in the past, the 2012 edition updates and expands the human research standards in many other countries based on information provided by in-country experts.
HIV Research Discovery
Louis Picker, MD's OHSU lab at the Vaccine & Gene Therapy Institute was able to generate an immune response that was effective at the mucosa, where HIV is first encountered, and thereby prevent infection in 4/12 monkeys challenged with SIV (monkey HIV). They did this by using as vaccine vector CMV (a relatively benign herpesvirus) that was engineered to encoded a few SIV proteins. This is a big improvement over previous vaccine models that generally could not stop infection but kept the virus level low (if at all). Nature Medicine Summary, and whole article.
