Study finds Gingko biloba does not improve cognition in MS patients
09/13/12 Portland, Ore.
Results come after 2005 pilot study offered hope that supplement may have offered benefits
Many people with multiple sclerosis for years have taken the natural supplement Gingko biloba, believing it helps them with cognitive problems associated with the disease.
But the science now says otherwise. A new study published in the journal Neurology says Gingko biloba does not improve cognitive performance in people with multiple sclerosis. The research was published in the Sept. 5, 2012, issue of Neurology, the medical journal of the American Academy of Neurology.
The current study was a more extensive look at the question after a smaller 2005 pilot study suggested there might have been some cognitive benefits in MS patients using the supplement. That study found that Gingko seemed to improve attention in MS patients with cognitive impairment.
But the larger follow-up study, conducted with patients at the Portland and Seattle Veterans Affairs medical centers, found no cognitive benefits to using Gingko.
“It’s important for scientists to continue to analyze what might help people with cognitive issues relating to their MS," said Jesus Lovera, M.D., the study's lead author, a former fellow at the Portland VA Medical Center and former instructor in Oregon Health & Science University's Department of Neurology, where he did much of the work on the study. Lovera is now with the Department of Neurology at the Louisiana State University Health Sciences Center.
"We wanted to follow up on the earlier findings that suggested there may be some benefit. But we believe this larger study settles the question: Gingko simply doesn't improve cognitive performance with MS patients," said Lovera.
About one-half of people with MS will develop cognitive problems, and those cognitive problems can be debilitating in some people, said Dennis Bourdette, M.D., a co-author of the study, co-director of the VA MS Center of Excellence-West at the Portland VA Medical Center and chairman of the OHSU Department of Neurology. The most common problems relate to memory, attention and concentration, and information processing.
There is no known treatment that can improve cognition with MS patients — which is partly why MS patients and researchers had hoped that Gingko biloba could help.
Lovera was also the lead author in the 2005 study, conducted at OHSU. That study included 39 participants who were given Gingko biloba or a placebo. The new study included 120 participants given Gingko or a placebo.
The study was supported by a grant from the U.S. Department of Veterans Affairs Rehabilitation Research and Development Service.
Oregon Health & Science University is the state's only health and research university and its only academic health center. As Portland's largest employer, OHSU's size contributes to its ability to provide many services and community support activities not found anywhere else in the state. OHSU serves patients from every corner of the state and is a conduit for learning for more than 4,300 students and trainees. OHSU is the source of more than 200 community outreach programs that bring health and education services to each county in the state.
About the Portland VA Medical Center
The Portland VA Medical Center is a 303-bed consolidated facility with two main divisions. The medical center serves as the quaternary referral center for Oregon, Southern Washington, and parts of Idaho for the U.S. Department of Veterans Affairs. The Portland VAMC is located atop Marquam Hill on 28.5 acres overlooking the city of Portland. In addition to comprehensive medical and mental health services, the Portland VAMC supports ongoing research and medical education, including nationally funded Mood Disorders and Hepatitis C Resource Centers.
In addition to the main medical center in Portland, PVAMC offers many health care services from its Vancouver, Wash., campus as well as eight community outpatient clinics located in Bend, East Portland, Hillsboro, Warrington, Newport, Salem, The Dalles, and West Linn.