Scientists discover cell of origin for childhood muscle cancer
02/14/11 Portland, Ore.
Knowing the genetic and cellular origins of cancers helps clinicians design specific therapies that work best for each individual cancer
Researchers at Oregon Health & Science University Doernbecher Children’s Hospital have defined the cell of origin for a kind of cancer called sarcoma. In a study published today as the Featured Article in the journal Cancer Cell, they report that childhood and adult sarcomas are linked in their biology, mutations and the cells from which these tumors first start. These findings may lead to non-chemotherapy medicines that can inhibit “molecular targets” such as growth factor receptors, thereby stopping or eradicating the disease.
Childhood muscle cancer, or rhabdomyosarcoma, is a condition that when spread throughout the body has a low survival rate — just 20 percent to 40 percent. In adults with soft tissue sarcomas, survival can be even lower. Now, for the first time, the researchers have shown from where these tumors arise and what drives them to grow and spread.
“A commonly held belief is that cancers should be cut out, burned out or killed. There is a fourth option — to have cancer cells choose to become normal cells, in this case muscle cells,” said Charles Keller, M.D., principal investigator of the study, leader of Pediatric Cancer Biology Program in the Papé Family Pediatric Research Institute at OHSU Doernbecher Children’s Hospital, and a member of the OHSU Knight Cancer Institute and the Oregon Stem Cell Center at OHSU.
“At least for a subset of patients, possibly the ones with hereditary cancer, one approach suggested by our research might be to administer drugs that muscle cancers to convert into non-cancerous muscle fibers. This is a minority opinion, but one held by a small group of careful scientists throughout the United States and abroad,” said Keller.
The survival rate for childhood muscle cancer that has spread has remained unchanged for more than 40 years. It has reached the point that increasing the intensity of chemotherapy, radiation or surgery is no longer having any improved effect, Keller explained. He and colleagues have taken a novel approach in the laboratory as well as in new clinical trials, using non-chemotherapy medicines to inhibit “molecular targets” such as growth factor receptors.
Suman Malempati, M.D., assistant professor of pediatrics (hematology/oncology) and director of the Oncology Developmental Therapeutics Program at OHSU Doernbecher Children’s Hospital, is the lead on a national clinical trial of one such growth factor inhibitor. This is the Children’s Oncology Group’s first trial incorporating a molecularly targeted drug into a clinical trial for childhood muscle cancer and was funded by CureSearch for Children’s Cancer, a nationwide network of hospitals, doctors and leading scientists that develop new treatments for childhood cancer.
This type of therapy tailored to a cancer’s mutation was first pioneered at OHSU by Brian J. Druker, M.D., director of the OHSU Knight Cancer Institute and recipient of the 2009 Lasker~DeBakey Clinical Medical Research Award, commonly referred to as America’s Nobel Prize. Druker and colleagues developed Gleevec, the first genetically targeted, non-chemotherapy pill for chronic myeloid leukemia (CML) that left healthy cells unharmed and converted this fatal cancer into a manageable chronic condition.
This research was funded by the National Cancer Institute and the Scott Carter Foundation.
About OHSU Doernbecher Children’s Hospital
OHSU Doernbecher Children's Hospital is a world-class facility that each year cares for tens of thousands of children from Oregon, southwest Washington and around the nation, including national and international referrals for specialty care. Children have access to a full range of pediatric care, not just treatments for serious illness or injury, resulting in more than 165,000 outpatient visits, discharges, surgeries and pediatric transports annually. Nationally recognized physicians ensure that children receive exceptional care, including outstanding cancer treatment, specialized neurology care and highly sophisticated heart surgery in the most patient- and family-centered environment. Pediatric experts from OHSU Doernbecher travel throughout Oregon and southwest Washington to provide specialty care to some 3,000 children at more than 154 outreach clinics in 13 locations.
Children's Oncology Group and CureSearch for Children's Cancer
CureSearch for Children's Cancer funds the live saving research of the Children's Oncology Group (COG), the world's largest cooperative pediatric cancer research entity. Comprised of a network for 210 member hospitals and more than 6,500 member physicians and medical professionals worldwide, COG clinical and translational research has improved overall cure rates from 10 percent 40 years ago to 78 percent today. In the United States, 90 percent of children with cancer receive treatment at a COG member hospital.